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An ultrasensitive fluorescent breath ammonia sensor for noninvasive diagnosis of chronic kidney disease and helicobacter pylori infection
Song, Guangjie1,2; Jiang, Di1; Wu, Jianchang2; Sun, Xiangzhong2,3; Deng, Mengyu2; Wang, Lei2; Hao, Changxiang2; Shi, Jiayan2; Liu, Hongtian2; Tian, Yanqing2; Chen, Meiwan1
2022-07-15
Source PublicationChemical Engineering Journal
ISSN1385-8947
Volume440
Abstract

Breath ammonia detection has been a significant non-invasive approach for disease diagnosis. However, the reported methods for breath ammonia detection suffer from high cost, time-consuming, complex operation, or low selectivity. Fluorescence analysis as an alternative method has not been introduced in the detection of breath ammonia due to its insufficient sensitivity. In this work, a rationally designed strategy is proposed to improve the sensitivity of fluorescence sensors by increasing the amount of recognition site and enhancing the brightness of the solid-state fluorescence in sensor molecule. Briefly, three curcumin (CUR) derivatives BFCUR, MBFCUR and MBFCURM with D-π-A-π-D conjugated system were synthesized. Compared with the other two control molecules MBFCUR and MBFCURM, whose phenol groups at one or both ends of BFCUR were protected by a methyl group, BFCUR has two response sites, thus, two intramolecular charge transfer (ICT) interactions occurred after exposure to ammonia, suggesting the improved sensitivity. Moreover, the large steric hindrance of boron trifluoride in BFCUR can prevent the π-π stacking of molecules and endow BFCUR with bright solid-state fluorescence. BFCUR was subsequently loaded into electrospun nanofibers (ENFs) with high specific surface area, which further improved the detection sensitivity. The obtained BFCUR-loaded ENFs sensor (denoted as BFCUR-ENF) exhibited ultra-low LOD of 22 ppb for ammonia. BFCUR-ENF is successfully applied to breath ammonia detection in healthy volunteers, patients with chronic kidney disease (CKD) and Helicobacter pylori (H. pylori) infection, demonstrating its great application potentials. Taken together, the first fluorescent sensor for breath ammonia detection was successfully constructed for noninvasive diagnosis of CKD and H. pylori.

KeywordBreath Ammonia Chronic Kidney Disease Fluorescence Sensor Helicobacter Pylori Non-invasive Diagnosis
DOI10.1016/j.cej.2022.135979
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaEngineering
WOS SubjectEngineering, Environmental ; Engineering, Chemical
WOS IDWOS:000795095400005
Scopus ID2-s2.0-85126958383
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorTian, Yanqing; Chen, Meiwan
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China
2.Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, 518055, China
3.School of Physics and Technology, Wuhan University, Wuhan, 430072, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Song, Guangjie,Jiang, Di,Wu, Jianchang,et al. An ultrasensitive fluorescent breath ammonia sensor for noninvasive diagnosis of chronic kidney disease and helicobacter pylori infection[J]. Chemical Engineering Journal,2022,440.
APA Song, Guangjie,Jiang, Di,Wu, Jianchang,Sun, Xiangzhong,Deng, Mengyu,Wang, Lei,Hao, Changxiang,Shi, Jiayan,Liu, Hongtian,Tian, Yanqing,&Chen, Meiwan.(2022).An ultrasensitive fluorescent breath ammonia sensor for noninvasive diagnosis of chronic kidney disease and helicobacter pylori infection.Chemical Engineering Journal,440.
MLA Song, Guangjie,et al."An ultrasensitive fluorescent breath ammonia sensor for noninvasive diagnosis of chronic kidney disease and helicobacter pylori infection".Chemical Engineering Journal 440(2022).
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