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Adjunctive tDCS for treatment-refractory auditory hallucinations in schizophrenia: A meta-analysis of randomized, double-blinded, sham-controlled studies
Jiang, Wen Long1; Cai, Dong Bin2; Sun, Chen Hui3; Yin, Fei4; Goerigk, Stephan5,6,7; Brunoni, Andre Russowsky8,9,10; Zhao, Xi Wu1; Mayes, Taryn L.11; Zheng, Wei12; Xiang, Yu Tao13
2022-07-01
Source PublicationAsian Journal of Psychiatry
ISSN1876-2018
Volume73
Abstract

Objective: Treatment-refractory auditory hallucinations (TRAH) in schizophrenia often do not improve with pharmacotherapy. We performed a meta-analysis of randomized, double-blind, sham-controlled clinical trials (RCTs) that systematically examined the therapeutic effects and tolerability of adjunctive active versus sham active transcranial direct current stimulation (tDCS) for auditory hallucinations as measured by the Auditory Hallucination Rating Scale (AHRS) in schizophrenia patients with TRAH. Methods: Relevant data were extracted, checked and analyzed using the Review Manager, Version 5.3 by three independent investigators. Results: Eight double-blind RCTs covering 329 schizophrenia patients (168 in active tDCS group, 161 in sham tDCS group) were included. Although no advantage of active tDCS on auditory hallucinations [7 RCTs, n = 224; standardized mean difference (SMD): − 0.33 (95% confidence interval (CI): − 0.71, 0.05), P = 0.09; I = 46%] was found compared to sham, subgroup analyses revealed that active tDCS with twice-daily stimulation [6 RCTs, n = 198; SMD: − 0.42 (95%CI: −0.82, −0.02), P = 0.04; I = 44%] and active tDCS with ≥ 10 stimulation sessions [6 RCTs, n = 198; SMD: − 0.42 (95%CI: −0.82, −0.02), P = 0.04; I = 44%] showed a significantly better therapeutic effect than sham in improving auditory hallucinations symptoms. Meta-analyses of total psychopathology and discontinuation due to any reason were not significantly different between the active and sham tDCS groups. Conclusion: This meta-analysis demonstrated that the effects of tDCS for auditory hallucinations symptoms were influenced by the tDCS parameters. Twice-daily stimulation and ≥ 10 stimulation sessions may be needed to improve auditory hallucinations symptoms in schizophrenia with TRAH.

KeywordAuditory Hallucinations Meta-analysis Rct Schizophrenia Tdcs
DOI10.1016/j.ajp.2022.103100
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000832879900006
Scopus ID2-s2.0-85128236488
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorZheng, Wei; Xiang, Yu Tao
Affiliation1.The Third People's Hospital of Daqing, Daqing, China
2.Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
3.Qingdao Mental Health Center, Qingdao University, Qingdao, China
4.Harbin Medical University Daqing Campus, Daqing, China
5.Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany
6.Department of Psychological Methodology and Assessment, Ludwig-Maximilians-University, Munich, Germany
7.Hochschule Fresenius, University of Applied Sciences, Munich, Germany
8.Center for Clinical and Epidemiological Research & Interdisciplinary Center for Applied Neuromodulation, University Hospital, University of São Paulo, São Paulo, Brazil
9.Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil
10.Laboratory of Neuroscience and National Institute of Biomarkers in Psychiatry, Department and Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil
11.Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, United States
12.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
13.Unit of Psychiatry, Department of Public Health and Medicinal Administration, & Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Jiang, Wen Long,Cai, Dong Bin,Sun, Chen Hui,et al. Adjunctive tDCS for treatment-refractory auditory hallucinations in schizophrenia: A meta-analysis of randomized, double-blinded, sham-controlled studies[J]. Asian Journal of Psychiatry,2022,73.
APA Jiang, Wen Long,Cai, Dong Bin,Sun, Chen Hui,Yin, Fei,Goerigk, Stephan,Brunoni, Andre Russowsky,Zhao, Xi Wu,Mayes, Taryn L.,Zheng, Wei,&Xiang, Yu Tao.(2022).Adjunctive tDCS for treatment-refractory auditory hallucinations in schizophrenia: A meta-analysis of randomized, double-blinded, sham-controlled studies.Asian Journal of Psychiatry,73.
MLA Jiang, Wen Long,et al."Adjunctive tDCS for treatment-refractory auditory hallucinations in schizophrenia: A meta-analysis of randomized, double-blinded, sham-controlled studies".Asian Journal of Psychiatry 73(2022).
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