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Highly Site- and Enantioselective N—H Functionalization of N-Monosubstituted Aniline Derivatives Affording Pyrazolones Bearing a Quaternary Stereocenter
Wang, Guan Jun1; Zhang, Shu Yu1; Sun, Zhen Liang2; Li, Peng3; Ding, Tong Mei1
2022-05-15
Source PublicationChinese Journal of Chemistry
ISSN1001-604X
Volume40Issue:10Pages:1144-1148
Other Abstract

Chiral phosphoric acid catalyzed the regio- and enantioselective N—H functionalization of N-alkylaniline with pyrazolones derived ketimines as electrophiles, providing a variety of chiral pyrazolones containing a tetrasubstituted stereocenter bearing a new N,N’-acetal motif in excellent yields and high enantioselectivities. This strategy was featured by low catalyst loading, mild conditions, and high efficiency and selectivity.

KeywordAlkylation Asymmetric Synthesis Enantioselectivity Nitrogen Heterocycles Quaternary Stereocenter
DOI10.1002/cjoc.202100828
URLView the original
Indexed BySCIE ; IC
Language英語English
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000750140500001
Scopus ID2-s2.0-85124898055
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorSun, Zhen Liang; Ding, Tong Mei
Affiliation1.School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China
2.Southern Medical University Affiliated Fengxian Hospital, Shanghai, 201499, China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, 999078, China
Recommended Citation
GB/T 7714
Wang, Guan Jun,Zhang, Shu Yu,Sun, Zhen Liang,et al. Highly Site- and Enantioselective N—H Functionalization of N-Monosubstituted Aniline Derivatives Affording Pyrazolones Bearing a Quaternary Stereocenter[J]. Chinese Journal of Chemistry,2022,40(10):1144-1148.
APA Wang, Guan Jun,Zhang, Shu Yu,Sun, Zhen Liang,Li, Peng,&Ding, Tong Mei.(2022).Highly Site- and Enantioselective N—H Functionalization of N-Monosubstituted Aniline Derivatives Affording Pyrazolones Bearing a Quaternary Stereocenter.Chinese Journal of Chemistry,40(10),1144-1148.
MLA Wang, Guan Jun,et al."Highly Site- and Enantioselective N—H Functionalization of N-Monosubstituted Aniline Derivatives Affording Pyrazolones Bearing a Quaternary Stereocenter".Chinese Journal of Chemistry 40.10(2022):1144-1148.
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