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Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3
Li, Dan1,2; Yang, Chao2,3; Zhu, Jian zhong2; Lopez, Eduardo4; Zhang, Tian2; Tong, Qiang4; Peng, Cheng1; Lin, Li gen2
2022-05
Source PublicationActa Pharmacologica Sinica
ISSN1671-4083
Volume43Issue:5Pages:1285-1298
Abstract

Adipose tissue remodelling is considered a critical pathophysiological hallmark of obesity and related metabolic diseases. Berberine (BBR), a natural isoquinoline alkaloid, has potent anti-hyperlipidaemic and anti-hyperglycaemic effects. This study aimed to explore the role of BBR in modulating adipose tissue remodelling and the underlying mechanisms. BBR protected high fat diet (HFD)-fed mice against adiposity, insulin resistance and hyperlipidemia. BBR alleviated adipose tissue inflammation and fibrosis by inhibiting macrophage infiltration, pro-inflammatory macrophage polarization and the abnormal deposition of extracellular matrix, and the effect was mediated by BBR directly binding and activating the deacetylase Sirtuin 3 (SIRT3) and suppressing the activation of the mitogen-activated protein kinases and nuclear factor-κB signalling pathways. Furthermore, BBR decreased microRNA-155-5p secretion by macrophages, which in turn ameliorated liver injury. Moreover, BBR mitigated inflammatory responses in both LPS-stimulated macrophages and TNF-α-treated adipocytes and suppressed macrophage migration towards adipocytes by activating SIRT3. Collectively, this study revealed that BBR improved adipose tissue remodelling, and subsequently inhibited the secretion of microRNA-155-5p by macrophages, which alleviated adiposity, insulin resistance and liver injury in obese mice. The modulation of adipose tissue remodelling by activating SIRT3 could contribute to the anti-hyperlipidemic and anti-hyperglycemic effects of BBR.

KeywordAdipose Tissue Inflammation Berberine Fibrosis Insulin Resistance Liver Injury Sirtuin 3
DOI10.1038/s41401-021-00736-y
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary;pharmacology & Pharmacy
WOS IDWOS:000686879800003
Scopus ID2-s2.0-85113217418
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorPeng, Cheng; Lin, Li gen
Affiliation1.State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao
3.Key Laboratory of Health Risk Factors for Seafood and Environment of Zhejiang Province, Institute of Innovation & Application, Zhejiang Ocean University, Zhoushan, 316022, China
4.Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, United States
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Li, Dan,Yang, Chao,Zhu, Jian zhong,et al. Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3[J]. Acta Pharmacologica Sinica,2022,43(5):1285-1298.
APA Li, Dan,Yang, Chao,Zhu, Jian zhong,Lopez, Eduardo,Zhang, Tian,Tong, Qiang,Peng, Cheng,&Lin, Li gen.(2022).Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3.Acta Pharmacologica Sinica,43(5),1285-1298.
MLA Li, Dan,et al."Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3".Acta Pharmacologica Sinica 43.5(2022):1285-1298.
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