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Polysaccharides, Next Potential Agent for the Treatment of Epilepsy?
Xie, Xuemin1; Wu, Youliang1; Xie, Haitao1; Wang, Haiyan1; Zhang, Xiaojing1; Yu, Jiabin1; Zhu, Shaofang1; Zhao, Jing2; Sui, Lisen1; Li, Shaoping2
Source PublicationFrontiers in Pharmacology

Epilepsy is a chronic neurological disorder. Current pharmacological therapies for epilepsy have limited efficacy that result in refractory epilepsy (RE). Owing to the limitations of conventional therapies, it is needed to develop new anti-epileptic drugs. The beneficial effects of polysaccharides from Chinese medicines, such as Lycium barbarum polysaccharides (COP) and Ganoderma lucidum polysaccharides (GLP), for treatment of epilepsy include regulation of inflammatory factors, neurotransmitters, ion channels, and antioxidant reactions. Especially, polysaccharides could be digested by intestinal microbial flora, referred as “intestinal brain organ” or “adult’s second brain”, may be the target for treatment of epilepsy. Actually, polysaccharides can effectively improve the type and quantity of intestinal flora such as bifidobacteria and lactic acid bacteria and achieve the purpose of treating epilepsy. Therefore, polysaccharides are hypothesized and discussed as potential agent for treatment of epilepsy.

KeywordEpilepsy Gut Microbiome Polysaccharides Traditional Chinese Medicines Treatment
URLView the original
Indexed BySCIE
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000783335600001
Scopus ID2-s2.0-85128779423
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorSui, Lisen
Affiliation1.Department of Epilepsy Center, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, China
2.Joint Laboratory of Chinese Herbal Glycoengineering and Testing Technology, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao
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GB/T 7714
Xie, Xuemin,Wu, Youliang,Xie, Haitao,et al. Polysaccharides, Next Potential Agent for the Treatment of Epilepsy?[J]. Frontiers in Pharmacology,2022,13.
APA Xie, Xuemin,Wu, Youliang,Xie, Haitao,Wang, Haiyan,Zhang, Xiaojing,Yu, Jiabin,Zhu, Shaofang,Zhao, Jing,Sui, Lisen,&Li, Shaoping.(2022).Polysaccharides, Next Potential Agent for the Treatment of Epilepsy?.Frontiers in Pharmacology,13.
MLA Xie, Xuemin,et al."Polysaccharides, Next Potential Agent for the Treatment of Epilepsy?".Frontiers in Pharmacology 13(2022).
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