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Biomimetic Redox-Responsive Mesoporous Organosilica Nanoparticles Enhance Cisplatin-Based Chemotherapy
Chen, Fangman1,2; Zhang, Fan2; Wang, Yanbin3; Peng, Jiahui1,2; Cao, Lei1,2; Mei, Qian2; Ge, Mingfeng2; Li, Li2; Chen, Meiwan4; Dong, Wen Fei1,2; Chang, Zhimin2
Source PublicationFrontiers in Bioengineering and Biotechnology

Cisplatin-based chemotherapy is dominated in several cancers; however, insufficient therapeutic outcomes and systemic toxicity hamper their clinical applications. Controlled release of cisplatin and reducing inactivation remains an urgent challenge to overcome. Herein, diselenide-bridged mesoporous organosilica nanoparticles (MON) coated with biomimetic cancer cell membrane were tailored for coordination responsive controlled cisplatin delivery and GSH depletion to strengthen Pt-based chemotherapy. Cisplatin-loaded MON (MON-Pt) showed high loading capacity due to robust coordination between selenium and platinum atoms and preventing premature leakage in normal tissue. MON-Pt exhibited a controlled release of activated cisplatin in response to the redox tumor microenvironment. Meanwhile, MON-Pt containing redox-responsive diselenide bonds could efficiently scavenge intracellular inactivation agents, such as GSH, to enhance Pt-based chemotherapy. 4T1 breast cancer cell membranes cloaked MON-Pt (MON-Pt@CM) performed efficient anticancer performance and low in vivo system toxicity due to long blood circulation time and high tumor accumulation benefiting from the tumor targeting and immune-invasion properties of the homologic cancer cell membrane. These results suggest a biomimetic nanocarrier to control release and reduce the inactivation of cisplatin for efficient and safe Pt-based chemotherapy by responding and regulating the tumor microenvironment.

KeywordBiomimetic Nanocarrier Cisplatin Degradation Glutathione Depletion Mesoporous Silica Nanoparticles
URLView the original
Indexed BySCIE
WOS Research AreaBiotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS SubjectBiotechnology & Applied Microbiologymultidisciplinary Sciences
WOS IDWOS:000777706000001
Scopus ID2-s2.0-85127821923
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorDong, Wen Fei; Chang, Zhimin
Affiliation1.School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
2.CAS Key Laboratory of Bio Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences, Suzhou, China
3.Nephrology Department of the Fourth Affiliated Hospital of XinJiang Medical University, Macao
4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao
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GB/T 7714
Chen, Fangman,Zhang, Fan,Wang, Yanbin,et al. Biomimetic Redox-Responsive Mesoporous Organosilica Nanoparticles Enhance Cisplatin-Based Chemotherapy[J]. Frontiers in Bioengineering and Biotechnology,2022,10.
APA Chen, Fangman,Zhang, Fan,Wang, Yanbin,Peng, Jiahui,Cao, Lei,Mei, Qian,Ge, Mingfeng,Li, Li,Chen, Meiwan,Dong, Wen Fei,&Chang, Zhimin.(2022).Biomimetic Redox-Responsive Mesoporous Organosilica Nanoparticles Enhance Cisplatin-Based Chemotherapy.Frontiers in Bioengineering and Biotechnology,10.
MLA Chen, Fangman,et al."Biomimetic Redox-Responsive Mesoporous Organosilica Nanoparticles Enhance Cisplatin-Based Chemotherapy".Frontiers in Bioengineering and Biotechnology 10(2022).
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