UM  > Institute of Chinese Medical Sciences
Affiliated with RCtrue
Status已發表Published
Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine
Wang, Xuan; Hua, Peng; He, Chengwei; Chen, Meiwan
2022-09
Source PublicationActa Pharmaceutica Sinica B
ISSN2211-3835
Volume12Issue:9Pages:3567-3593
Abstract

As an emerging cancer therapeutic target, non-apoptotic cell death such as ferroptosis, necroptosis and pyroptosis, etc., has revealed significant potential in cancer treatment for bypassing apoptosis to enhance the undermined therapeutic efficacy triggered by apoptosis resistance. A variety of anticancer drugs, synthesized compounds and natural products have been proven recently to induce non-apoptotic cell death and exhibit excellent anti-tumor effects. Moreover, the convergence of nanotechnology with functional materials and biomedicine science has provided tremendous opportunities to construct non-apoptotic cell death-based nanomedicine for innovative cancer therapy. Nanocarriers are not only employed in targeted delivery of non-apoptotic inducers, but also used as therapeutic components to induce non-apoptotic cell death to achieve efficient tumor treatment. This review first introduces the main characteristics, the mechanism and various pharmacological modulators of different non-apoptotic cell death forms, including ferroptosis, necroptosis, pyroptosis, autophagy, paraptosis, lysosomal-dependent cell death, and oncosis. Second, we comprehensively review the latest progresses of nanomedicine that induces various forms of non-apoptotic cell death and focus on the nanomedicine targeting different pathways and components. Furthermore, the combination therapies of non-apoptotic cell death with photothermal therapy, photodynamic therapy, immunotherapy and other modalities are summarized. Finally, the challenges and future perspectives in this regard are also discussed.

KeywordAnticancer Autophagy Combination Therapies Ferroptosis Nanomedicine Necroptosis Non-apoptotic Cell Death Pyroptosis
DOI10.1016/j.apsb.2022.03.020
URLView the original
Language英語English
Scopus ID2-s2.0-85128228340
Fulltext Access
Citation statistics
Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, SAR 999078, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wang, Xuan,Hua, Peng,He, Chengwei,et al. Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine[J]. Acta Pharmaceutica Sinica B,2022,12(9):3567-3593.
APA Wang, Xuan,Hua, Peng,He, Chengwei,&Chen, Meiwan.(2022).Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine.Acta Pharmaceutica Sinica B,12(9),3567-3593.
MLA Wang, Xuan,et al."Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine".Acta Pharmaceutica Sinica B 12.9(2022):3567-3593.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Xuan]'s Articles
[Hua, Peng]'s Articles
[He, Chengwei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Xuan]'s Articles
[Hua, Peng]'s Articles
[He, Chengwei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Xuan]'s Articles
[Hua, Peng]'s Articles
[He, Chengwei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.