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The role of irisin in metabolic flexibility: Beyond adipose tissue browning
Shen, Shengnan1,2; Liao, Qiwen3; Chen, Xiuping1; Peng, Cheng4; Lin, Ligen1,5
2022
Source PublicationDrug Discovery Today
ISSN1359-6446
AbstractMetabolic flexibility is the ability to adapt to physiological and environmental changes in metabolic demand. Irisin was originally discovered as an exercise-induced myokine involved in fat browning. In this review, we summarize emerging evidence for the roles of irisin in regulating glucose metabolism and insulin sensitivity in skeletal muscle, neuroplasticity and satiety in central nervous system, β cell function and insulin secretion in the pancreas, bone remodeling, and adipose tissue function, which together orchestrate whole-body metabolic flexibility. Irisin is a key communicating mediator between skeletal muscle and other organs, and its manipulation could be a promising therapeutic strategy for treating obesity and related metabolic disorders.
KeywordFNDC5 Insulin sensitivity Irisin Metabolic flexibility Obesity Skeletal muscle
DOI10.1016/j.drudis.2022.03.019
URLView the original
Language英語English
Scopus ID2-s2.0-85127682374
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao
2.Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
3.School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Guangdong, China
4.State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
5.Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Macao
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Shen, Shengnan,Liao, Qiwen,Chen, Xiuping,et al. The role of irisin in metabolic flexibility: Beyond adipose tissue browning[J]. Drug Discovery Today,2022.
APA Shen, Shengnan,Liao, Qiwen,Chen, Xiuping,Peng, Cheng,&Lin, Ligen.(2022).The role of irisin in metabolic flexibility: Beyond adipose tissue browning.Drug Discovery Today.
MLA Shen, Shengnan,et al."The role of irisin in metabolic flexibility: Beyond adipose tissue browning".Drug Discovery Today (2022).
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