UM  > Institute of Chinese Medical Sciences
Affiliated with RCfalse
Status已發表Published
Acid-Responsive Dual-Targeted Nanoparticles Encapsulated Aspirin Rescue the Immune Activation and Phenotype in Autism Spectrum Disorder
He, Xueqin1; Xie, Jiang1,2; Zhang, Jing1; Wang, Xiaorong1; Jia, Xufeng1,2; Yin, Heng1,2; Qiu, Zhongqing1,2; Yang, Zhihang1; Chen, Jiao3; Ji, Zhiliang3; Yu, Wenqi1; Chen, Meiwan4; Xu, Wenming1; Gao, Huile1
2022-05-16
Source PublicationAdvanced Science
Other Abstract

The treatment of autism spectrum disorder (ASD) is one of the most difficult challenges in neurodevelopmental diseases, because of the unclear pathogenesis research and low brain-lesion targeting efficiency. Besides, maternal immune activation has been reported as the most mature and widely used model of ASD and aspirin-triggered lipoxin A4 is a potent anti-inflammatory mediator being involved in the resolution of neuroinflammation in ASD. Therefore, an aspirin encapsulated cascade drug delivery system (Asp@TMNPs) is established, which can successively target the blood–brain barrier (BBB) and microglial cells and response to the acid microenvironment in lysosome. As a result, the mitochondrial oxidative stress, DNA damage, and inflammation of microglial cells are prominently alleviated. After the treatment of Asp@TMNPs, the social interaction, stereotype behavior, and anxious condition of ASD mice are notably improved and the activation of microglial cells is inhibited. Overall, this system successively penetrates the BBB and targets microglial cells, therefore, it significantly enhances the intracephalic drug accumulation and improves anti-neuroinflammatory efficacy of aspirin, providing a promising strategy for ASD treatment.

KeywordAspirin Autism Spectrum Disorder Nanoparticles Neuro-inflammation
DOI10.1002/advs.202104286
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000768167900001
Scopus ID2-s2.0-85126090704
Fulltext Access
Citation statistics
Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorXu, Wenming; Gao, Huile
Affiliation1.Key Laboratory of Drug-Targeting and Drug Delivery of MOE, West China Second University Hospital, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China
2.Department of pediatrics, Chengdu Third People's Hospital, Chengdu, 610041, China
3.State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, 361102, China
4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 999078, Macao
Recommended Citation
GB/T 7714
He, Xueqin,Xie, Jiang,Zhang, Jing,et al. Acid-Responsive Dual-Targeted Nanoparticles Encapsulated Aspirin Rescue the Immune Activation and Phenotype in Autism Spectrum Disorder[J]. Advanced Science,2022.
APA He, Xueqin,Xie, Jiang,Zhang, Jing,Wang, Xiaorong,Jia, Xufeng,Yin, Heng,Qiu, Zhongqing,Yang, Zhihang,Chen, Jiao,Ji, Zhiliang,Yu, Wenqi,Chen, Meiwan,Xu, Wenming,&Gao, Huile.(2022).Acid-Responsive Dual-Targeted Nanoparticles Encapsulated Aspirin Rescue the Immune Activation and Phenotype in Autism Spectrum Disorder.Advanced Science.
MLA He, Xueqin,et al."Acid-Responsive Dual-Targeted Nanoparticles Encapsulated Aspirin Rescue the Immune Activation and Phenotype in Autism Spectrum Disorder".Advanced Science (2022).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[He, Xueqin]'s Articles
[Xie, Jiang]'s Articles
[Zhang, Jing]'s Articles
Baidu academic
Similar articles in Baidu academic
[He, Xueqin]'s Articles
[Xie, Jiang]'s Articles
[Zhang, Jing]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[He, Xueqin]'s Articles
[Xie, Jiang]'s Articles
[Zhang, Jing]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.