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Clinical utility of heparin-binding protein as an acute-phase inflammatory marker in interstitial lung disease
Xue, Mingshan1; Zhang, Teng2; Lin, Runpei1; Zeng, Yifeng1; Cheng, Zhangkai Jason1; Li, Ning1; Zheng, Peiyan1; Huang, Huimin1; Zhang, Xiaohua Douglas2; Wang, Hongman3; Sun, Baoqing1
Source PublicationJournal of Leukocyte Biology

The role of heparin-binding protein (HBP) as an acute inflammatory marker in acute exacerbations of interstitial lung disease (AE-ILD) and some stable ILD patients is not well-established. The significance of increasing HBP during an AE-ILD is examined and the first attempt to incorporate HBP into the ILD evaluation system is made. Then, the benefit of HBP in AE-ILD was investigated. ILD patients (n = 108) were divided into subgroups based on the phase and severity of the disease. Linear trends of HBP across subgroups were observed, and correlations with common inflammatory markers were examined. Further, the HBP detection was adopted between serum and bronchoalveolar lavage fluid (BALF). Imaging and pathology changes were evaluated using various scoring criteria and compared to HBP. The relationship between HBP with ventilation, fibrosis progression, and changes in arterial oxygen levels and inflammatory markers were investigated to understand the mechanistic pathways. HBP was significantly higher in patients with AE-ILD at the early stage, compared to patients with ILD at the stable phase and its increase was both found in the serum and BALF. With the remission of the disease, there was a linear trend of progressive decline. HBP identified ILD patients who had co-infections. HBP levels increased earlier than CRP, PCT, and SAA. HBP was associated with pulmonary levels of ventilation and lesions by radiology examination, and its levels were significantly worse in AE-ILD patients. However, HBP did not show a correlation to the pathology quantitative evaluation. In conclusion, HBP could potentially evaluate the progression and prognosis of AE-ILD. Because ILD patients are susceptible to infection, and since HBP can identify co-infection, this marker would be of great clinical importance. HBP is possibly predictive of acute exacerbation.

KeywordAe-ild Ctd-ild Heparin-binding Protein Ipf
URLView the original
Indexed BySCIE
WOS Research AreaCell Biology ; Hematology ; Immunology
WOS SubjectCell Biology ; Hematology ; Immunology
WOS IDWOS:000754561800001
Scopus ID2-s2.0-85124501298
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorSun, Baoqing
Affiliation1.National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institue of Respiratory Health
2.Faculty of Health Sciences, University of Macau, Taipa, Macao
3.Department of Respiratory and Critical Care Medicine, The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, China
Recommended Citation
GB/T 7714
Xue, Mingshan,Zhang, Teng,Lin, Runpei,et al. Clinical utility of heparin-binding protein as an acute-phase inflammatory marker in interstitial lung disease[J]. Journal of Leukocyte Biology,2022.
APA Xue, Mingshan,Zhang, Teng,Lin, Runpei,Zeng, Yifeng,Cheng, Zhangkai Jason,Li, Ning,Zheng, Peiyan,Huang, Huimin,Zhang, Xiaohua Douglas,Wang, Hongman,&Sun, Baoqing.(2022).Clinical utility of heparin-binding protein as an acute-phase inflammatory marker in interstitial lung disease.Journal of Leukocyte Biology.
MLA Xue, Mingshan,et al."Clinical utility of heparin-binding protein as an acute-phase inflammatory marker in interstitial lung disease".Journal of Leukocyte Biology (2022).
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