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Antidepressive effects of a chemically characterized maqui berry extract (Aristotelia chilensis (molina) stuntz) in a mouse model of Post-stroke depression
Di Lorenzo, Arianna1; Sobolev, Anatoly P.2; Nabavi, Seyed Fazel3; Sureda, Antoni4; Moghaddam, Akbar Hajizadeh5; Khanjani, Sedigheh6; Di Giovanni, Carmen10; Xiao, Jianbo7; Shirooie, Samira8; Tsetegho Sokeng, Arold Jorel1; Baldi, Alessandra1; Mannina, Luisa2,9; Nabavi, Seyed Mohammad3; Daglia, Maria1
2019-07-01
Source PublicationFood and Chemical Toxicology
ISSN0278-6915
Volume129Pages:434-443
AbstractMood disorders occur in 30% of stroke patients, and of these post-stroke depression (PSD) is the most significant. This study aimed to evaluate the antidepressive-like effects and in vivo antioxidant activity of a chemically characterized maqui berry (Aristotelia chilensis (Molina) Stuntz) extract obtained from an optimized extraction method, on a murine PSD model. The extraction process was optimized to maximize anthocyanin content, and the phytochemical profile of the extract was evaluated using a multi-methodological approach including a liquid chromatographic method coupled with mass spectrometry and nuclear magnetic resonance spectroscopy. The antidepressive-like activity was investigated through despair swimming and tail suspension tests. The in vivo antioxidant activity was evaluated in mouse brain tissue by measuring the activity of antioxidant enzymes and lipid peroxidation products. A number of compounds have been first identified in maqui berry here, including malvidin-glucoside, GABA, choline and trigonelline. Moreover, the results showed that the antidepressive-like activity exerted by the extract, which was found to restore normal mouse behavior in both despair swimming and tail suspension tests, could be linked to its antioxidant activity, leading to the conclusion that maqui berries might be useful for supporting pharmacological therapy of PSD by modulating oxidative stress.
KeywordChemical characterization In vivo antioxidant activity Maqui berry extract Murine model system Post-stroke depression
DOI10.1016/j.fct.2019.04.023
URLView the original
Language英語English
Scopus ID2-s2.0-85065500724
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Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, Pavia, Viale Taramelli 12, 27100, Italy
2.Istituto di Metodologie Chimiche, Laboratorio di Risonanza Magnetica “Annalaura Segre”, CNR, Monterotondo (Rome), 00015, Italy
3.Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, P.O. Box, 19395-5487, 19395-5487, Iran
4.Grup de Nutrició Comunitària I Estrès Oxidatiu and CIBEROBN (Physiopathology of Obesity and Nutrition), Universitat de les Illes Balears, Palma de Mallorca, E-07122, Spain
5.Department of Biology, Faculty of Sciences, University of Mazandaran, Babolsar, Iran
6.Department of Physiology, Faculty of Biological Sciences, Shahid Behshti University, Tehran, P.O. Box, 19615-1178, 19615-1178, Iran
7.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Control in Chinese Medicine, University of Macau, Macau SAR, China
8.School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, Iran
9.Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Rome, P.le Aldo Moro 5, 00185, Italy
10.Department of Pharmacy, University of Naples Federico II, Napoli, Via Domenico Montesano, 49, 80131, Italy
Recommended Citation
GB/T 7714
Di Lorenzo, Arianna,Sobolev, Anatoly P.,Nabavi, Seyed Fazel,et al. Antidepressive effects of a chemically characterized maqui berry extract (Aristotelia chilensis (molina) stuntz) in a mouse model of Post-stroke depression[J]. Food and Chemical Toxicology,2019,129:434-443.
APA Di Lorenzo, Arianna,Sobolev, Anatoly P.,Nabavi, Seyed Fazel,Sureda, Antoni,Moghaddam, Akbar Hajizadeh,Khanjani, Sedigheh,Di Giovanni, Carmen,Xiao, Jianbo,Shirooie, Samira,Tsetegho Sokeng, Arold Jorel,Baldi, Alessandra,Mannina, Luisa,Nabavi, Seyed Mohammad,&Daglia, Maria.(2019).Antidepressive effects of a chemically characterized maqui berry extract (Aristotelia chilensis (molina) stuntz) in a mouse model of Post-stroke depression.Food and Chemical Toxicology,129,434-443.
MLA Di Lorenzo, Arianna,et al."Antidepressive effects of a chemically characterized maqui berry extract (Aristotelia chilensis (molina) stuntz) in a mouse model of Post-stroke depression".Food and Chemical Toxicology 129(2019):434-443.
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