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Expression of IL-1 mRNA in the dentate gyrus of adult rats following lithium-pilocarione-induced seizures
Zhang S.J.; Li X.W.; Wang Y.; Wei D.; Jiang W.
2010-03-01
Source PublicationXi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
ISSN10078738
Volume26Issue:3Pages:288-290
AbstractAIM: To examine the expression of IL-1beta, IL-1ra and IL-1R mRNA in the dentate gyrus of adult rats after lithium-pilocarpine (Li-PILO)-induced seizures. METHODS: Seizure epilepticus (SE) was induced using Li-PILO intraperitoneally (i.p.) injection. Lithium chloride was injected 18-20 h prior to PILO. The rats in the control group were given physiological saline instead of pilocarpine. We observed the behavior of rats and examined the expression of cytokines mRNA in dentate gyrus by RT-PCR. RESULTS: Rats had seizure epilepticus in 30 min after administrated of pilocarpine. Cytokines (IL-1beta, IL-1ra and IL-1R) began to increase significantly (P<0.05) at 1 h after SE, and the peak was at 6-12 h. Expression of all cytokines declined on 48 h after SE. CONCLUSION: Our findings suggested that SE lead to increased expression of IL-1, IL-1ra and IL-1R1 after lithium-pilocarpine-induced seizures, indicating that cytokines involved in SE and brain impairment after seizure.
URLView the original
Language英語English
Fulltext Access
Document TypeJournal article
CollectionUniversity of Macau
AffiliationXijing Hospital
Recommended Citation
GB/T 7714
Zhang S.J.,Li X.W.,Wang Y.,et al. Expression of IL-1 mRNA in the dentate gyrus of adult rats following lithium-pilocarione-induced seizures[J]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology,2010,26(3):288-290.
APA Zhang S.J.,Li X.W.,Wang Y.,Wei D.,&Jiang W..(2010).Expression of IL-1 mRNA in the dentate gyrus of adult rats following lithium-pilocarione-induced seizures.Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology,26(3),288-290.
MLA Zhang S.J.,et al."Expression of IL-1 mRNA in the dentate gyrus of adult rats following lithium-pilocarione-induced seizures".Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 26.3(2010):288-290.
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