UM  > Institute of Chinese Medical Sciences
Affiliated with RCfalse
Status即將出版Forthcoming
Tailoring therapeutic effect for chronotherapy of variant angina based on pharmacodynamic/deconvolution integrated model method
Li, Zhenghua1; Li, Ziyi1; Yu, Hua2; Wang, Bingwei1; Song, Wenting1; Liu, Jianping1
2022-08-01
Source PublicationEuropean Journal of Pharmaceutical Sciences
ISSN0928-0987
Volume175
Abstract

The onset of variant angina (VA) shows circadian rhythmicity that its attacks occur most often from midnight to early morning. Thus, chronotherapeutic treatments should be tailored accordingly to its occurrence frequency. Tanshinol (TS), the bioactive component of Salvia miltiorrhiza was used as the model drug. The pharmacokinetics, pharmacodynamics and PK-PD relationship of TS was investigated in angina model rabbits. The therapeutic effect of TS was evaluated from different aspects including cardiac injury, oxidative stress and vascular endothelium by measuring the serum levels of cTn-I, CK-MB, SOD and NO. In addition, the change of cTn-I levels from baseline as the pharmacodynamic endpoint was used for establishing the pharmacodynamic model. To synchronize the therapeutic effect profile of TS to the occurrence frequency of VA, ideal time courses of therapeutic effect, plasma concentration and drug release were simulated and calculated based on pharmacodynamic/deconvolution integrated model method. Then, sustained release pellets of TS (TS-SRPs) were developed according to the above calculated results and evaluated in vitro-in vivo. The established pharmacodynamic model of TS could precisely quantify the relationship between its effect and concentration. Then, ideal time courses of therapeutic effect, plasma concentration and release of TS were simulated and calculated successfully. After formulation optimization, the prepared TS-SRPs exhibited similar in vitro and in vivo behaviors to the corresponding ideal ones. Meanwhile, the effect curves of TS were synchronous with the occurrence frequency of VA, implying that appropriate therapeutic effect could be provided according to the needs of patients. In conclusion, the tailor of therapeutic effect based on integrated model method is efficient, feasible and reliable.

KeywordChronotherapy Pharmacodynamic/deconvolution Integrated Model Sustained Release Pellets Tanshinol Therapeutic Effect Variant Angina
DOI10.1016/j.ejps.2022.106208
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000806369600003
Scopus ID2-s2.0-85130211994
Fulltext Access
Citation statistics
Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLiu, Jianping
Affiliation1.Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China
2.Institute of Chinese Medical Sciences, University of Macau, Macau, China
Recommended Citation
GB/T 7714
Li, Zhenghua,Li, Ziyi,Yu, Hua,et al. Tailoring therapeutic effect for chronotherapy of variant angina based on pharmacodynamic/deconvolution integrated model method[J]. European Journal of Pharmaceutical Sciences,2022,175.
APA Li, Zhenghua,Li, Ziyi,Yu, Hua,Wang, Bingwei,Song, Wenting,&Liu, Jianping.(2022).Tailoring therapeutic effect for chronotherapy of variant angina based on pharmacodynamic/deconvolution integrated model method.European Journal of Pharmaceutical Sciences,175.
MLA Li, Zhenghua,et al."Tailoring therapeutic effect for chronotherapy of variant angina based on pharmacodynamic/deconvolution integrated model method".European Journal of Pharmaceutical Sciences 175(2022).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Zhenghua]'s Articles
[Li, Ziyi]'s Articles
[Yu, Hua]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Zhenghua]'s Articles
[Li, Ziyi]'s Articles
[Yu, Hua]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Zhenghua]'s Articles
[Li, Ziyi]'s Articles
[Yu, Hua]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.