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Dual nanoenzymes loaded hollow mesoporous organotantalum nanospheres for chemo-radio sensitization
Peng, Chao1,2,3; Liang, Yu1,2; Su, Ning1,2; Chen, Siwen2; Yuan, Zhen4; Chen, Yanqun5; Wu, Dong6; Wu, Bin6; Zhang, Yang1,2; Xu, Zi Ting1; Zheng, Si1; Li, Yingjia1; Zhao, Bingxia2,7
2022-07-01
Source PublicationJournal of Controlled Release
ISSN0168-3659
Volume347Pages:369-378
Abstract

Chemo-radiotherapy has been extensively used in clinics, displaying substantial advantages in treatment and prognosis. Stimuli-responsive biodegradable nanoagents that can achieve not only delivery and controlled release of chemotherapeutics, but also hypoxia alleviation to enhance chemoradiotherapy therefore has tremendous potential. Herein, glutathione (GSH)-responsive, biodegradable, doxorubicin-carrying hollow mesoporous organotantalum nanospheres modified with Au and Pt dual nanoenzymes (HMOTP@Pt@Au@Dox) were constructed for chemo-radio sensitization. Degradation of HMOTP@Pt@Au@Dox can be self-activated through GSH stimulation and on-demand release packaged Dox owing to the disulfide bond in the hybrid framework of organotantalum nanospheres. Au and Pt nanoenzymes triggered cascade catalytic reactions that could alleviate hypoxia by utilizing β-D-glucose and HO, thereby sensitizing ROS-based chemoradiotherapy with synergistic starving therapy. Given the radiosensitization of high-Z elements (Ta, Pt, Au), nanoenzymes induced cascade catalytic reaction for hypoxia relief, and the depletion of the predominant antioxidant GSH, desirable tumor suppression could be achieved both in vitro and in vivo, indicating that HMOTP@Pt@Au@Dox is a promising nanoagent to boost chemo-radiotherapy.

KeywordChemoradiotherapy Gsh-responsive Biodegradation Hypoxia-associated Resistance Nanoenzymes Organotantalum Nanospheres
DOI10.1016/j.jconrel.2022.05.018
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS IDWOS:000806755300005
Scopus ID2-s2.0-85130365299
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorPeng, Chao; Li, Yingjia; Zhao, Bingxia
Affiliation1.Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China
2.Guangzhou Key Laboratory of Tumor Immunology Research, Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China
3.Department of Cerebrovascular Diseases, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, 519099, China
4.Faculty of Health Sciences, University of Macau, Macau, 999078, China
5.Department of Oncology, Kiang Wu Hospital, Macau, 999078, China
6.Institute of Respiratory Diseases, Department of Respiratory, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China
7.Experimental Education/Administration Center, School of Basic Medical Science, Southern Medical University, Guangzhou, 510515, China
Recommended Citation
GB/T 7714
Peng, Chao,Liang, Yu,Su, Ning,et al. Dual nanoenzymes loaded hollow mesoporous organotantalum nanospheres for chemo-radio sensitization[J]. Journal of Controlled Release,2022,347:369-378.
APA Peng, Chao,Liang, Yu,Su, Ning,Chen, Siwen,Yuan, Zhen,Chen, Yanqun,Wu, Dong,Wu, Bin,Zhang, Yang,Xu, Zi Ting,Zheng, Si,Li, Yingjia,&Zhao, Bingxia.(2022).Dual nanoenzymes loaded hollow mesoporous organotantalum nanospheres for chemo-radio sensitization.Journal of Controlled Release,347,369-378.
MLA Peng, Chao,et al."Dual nanoenzymes loaded hollow mesoporous organotantalum nanospheres for chemo-radio sensitization".Journal of Controlled Release 347(2022):369-378.
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