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Determination of Transdermal Rate of Metallic Microneedle Array through an Impedance Measurements-Based Numerical Check Screening Algorithm
Mo, Jingshan1; Liu, Junqing2; Huang, Shuang1; Liang, Baoming1; Huang, Xinshuo1; Yang, Cheng1; Chen, Meiwan3; Liu, Jing4; Zhang, Tong5,6; Xie, Xi1,4; Guo, Jun2; Liu, Fanmao4; Chen, Hui Jiuan1
2022-04-30
Source PublicationMicromachines
ISSN2072-666X
Volume13Issue:5
Abstract

Microneedle systems have been widely used in health monitoring, painless drug delivery, and medical cosmetology. Although many studies on microneedle materials, structures, and applications have been conducted, the applications of microneedles often suffered from issues of inconsistent penetration rates due to the complication of skin-microneedle interface. In this study, we demonstrated a methodology of determination of transdermal rate of metallic microneedle array through impedance measurements-based numerical check screening algorithm. Metallic sheet microneedle array sensors with different sizes were fabricated to evaluate different transdermal rates. In vitro sensing of hydrogen peroxide confirmed the effect of transdermal rate on the sensing outcomes. An FEM simulation model of a microneedle array revealed the monotonous relation between the transdermal state and test current. Accordingly, two methods were primely derived to calculate the transdermal rate from the test current. First, an exact logic method provided the number of unpenetrated tips per sheet, but it required more rigorous testing results. Second, a fuzzy logic method provided an approximate transdermal rate on adjacent areas, being more applicable and robust to errors. Real-time transdermal rate estimation may be essential for improving the performance of microneedle systems, and this study provides various fundaments toward that goal.

KeywordComsol Impedance Measurement Microneedle Transdermal Rate
DOI10.3390/mi13050718
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Instruments & Instrumentation ; Physics
WOS SubjectChemistry, Analytical;nanoscience & Nanotechnology;instruments & Instrumentation;physics, Applied
WOS IDWOS:000803246900001
Scopus ID2-s2.0-85129945905
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Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorGuo, Jun; Liu, Fanmao; Chen, Hui Jiuan
Affiliation1.School of Electronics and Information Technology, State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, Sun Yat-Sen University, Guangzhou, 510006, China
2.Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China
4.The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China
5.School of Computer Science and Engineering, South China University of Technology, Guangzhou, 510006, China
6.Pazhou Lab, Guangzhou, 510335, China
Recommended Citation
GB/T 7714
Mo, Jingshan,Liu, Junqing,Huang, Shuang,et al. Determination of Transdermal Rate of Metallic Microneedle Array through an Impedance Measurements-Based Numerical Check Screening Algorithm[J]. Micromachines,2022,13(5).
APA Mo, Jingshan,Liu, Junqing,Huang, Shuang,Liang, Baoming,Huang, Xinshuo,Yang, Cheng,Chen, Meiwan,Liu, Jing,Zhang, Tong,Xie, Xi,Guo, Jun,Liu, Fanmao,&Chen, Hui Jiuan.(2022).Determination of Transdermal Rate of Metallic Microneedle Array through an Impedance Measurements-Based Numerical Check Screening Algorithm.Micromachines,13(5).
MLA Mo, Jingshan,et al."Determination of Transdermal Rate of Metallic Microneedle Array through an Impedance Measurements-Based Numerical Check Screening Algorithm".Micromachines 13.5(2022).
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