Cells and tissue microenvironment are like seeds and soil; the ‘soil’ supports the ‘seeds’ to grow, while the ‘seeds’ remodel the ‘soil’ through secretion. We aim to optimise the soil and thereby improve the seeds’ growth by targeting macrophages, which play central roles in wound healing and tissue repair. We design biomaterials tools and cell-based strategies to modulate macrophages’ phenotypes (e.g. via TLR-carbohydrate interaction), stabilise their secreted molecules (e.g. via growth factors-GAG interaction) and more generally create a pro-regenerative niche (e.g. by ‘utilising’ specifically induced macrophages). We are testing our concepts and designs with various models ranging from bone defects to dental implants to diabetic skin ulcers.
Dr Chunming Wang (CM) received his Bachelor and Master’s degrees in Biochemistry from Nanjing University (China), entering the field of biomaterials research under the supervision of Junfeng Zhang. He obtained his PhD in Biomedical Engineering from Nanyang Technological University (Singapore) under the supervision of Dong-An Wang. Then, CM undertook his postdoctoral training at the University of Cambridge(UK), working between Wilhelm Huck’s group in the Chemistry Department and Fiona Watt’s lab at the Wellcome Trust Centre for Stem Cell Research, before returning to Singapore to join the Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), where he assisted Simon Cool and Victor Nurcombe in collaboration with industry on a cross-institutional drug discovery project.
In Oct 2012, CM took the Assistant Professorship at ICMS, University of Macau, to continue his scientific exploration in developing bio-inspired materials for a wide range of medical applications. To date, he has won 10 research grants from O Fundo para o Desenvolvimento das Ciências e da Tecnologia de Macau (FDCT), National Natural Science Foundation of China (NSFC), University of Macau Research Committee as well as Nanjing University, China. These generous supports enabled the formation of ‘Chun Ming Tong Sui’ (春明糖水), a young and vibrant team devoted to weaving sweet polymer chains into new medicines. CMTS are also fortunate to have fantastic collaborators in Nanjing, Boston, Singapore and across Europe.
The team effort of CMTS has enabled CM to see himself among the winners of 2nd Prize of Natural Science Award at the 2016 Macao Science and Technology Awards.
Honors & Rewards