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1. Dstyk mutation leads to congenital scoliosis-like vertebral malfor.. [418]
2. Low-toxicity FePt nanoparticles for the targeted and enhanced diag.. [149]
3. Imaging of macrophage mitochondria dynamics in vivo reveals cellul.. [92]
4. BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activ.. [91]
5. FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophag.. [84]
6. PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regu.. [82]
7. Rmrp Mutation Disrupts Chondrogenesis and Bone Ossification in Zeb.. [81]
8. Adeno-Associated Virus-Mediated RNAi against Mutant Alleles Attenu.. [81]
9. The metabolic footprint during adipocyte commitment highlights cer.. [79]
10. Single-cell RNA-Seq reveals cell heterogeneity and hierarchy withi.. [72]
11. BRCA1 represses DNA replication initiation through antagonizing es.. [56]
12. A novel FGFR1-binding peptide exhibits anti-tumor effect on lung c.. [54]
13. Olfactomedin 4 deficiency promotes prostate neoplastic progression.. [50]
14. Inducible Activation of FGFR2 in Adult Mice Promotes Bone Formatio.. [48]
15. Cyclin B1 stability is increased by interaction with BRCA1, and it.. [47]
16. BRCA1 deficiency sensitizes breast cancer cells to bromodomain and.. [44]
17. Epigenetic targeting drugs potentiate chemotherapeutic effects in .. [43]
18. Postnatal deletion of Alk5 gene in meniscal cartilage accelerates .. [42]
19. Drug screening of cancer cell lines and human primary tumors using.. [40]
20. A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations i.. [40]
21. Optimizing CRISPR/Cas9 technology for precise correction of the Fg.. [40]
22. BRCA1 function in the intra-S checkpoint is activated by acetylati.. [39]
23. A novel FGFR1-binding peptide attenuates the degeneration ofarticu.. [38]
24. A digital microfluidic system for loop-mediated isothermal amplifi.. [36]
25. Characterization of potential driver mutations involved in human b.. [36]
26. Partial müllerian duct retention in Smad4 conditional mutant male.. [36]
27. A comprehensive genomic meta-analysis identifies confirmatory role.. [35]
28. Emerging roles of SIRT1 in fatty liver diseases [35]
29. Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but n.. [34]
30. Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but n.. [33]
31. WEE1 inhibition targets cell cycle checkpoints for triple negative.. [33]
32. SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mit.. [32]
33. Non-classical estrogen signaling in ovarian cancer improves chemo-.. [32]
34. Current Progresses of Exosomes as Cancer Diagnostic and Prognostic.. [31]
35. Centrosome amplification and a defective G2-M cell cycle checkpoin.. [28]
36. Potential therapeutic targets of triple-negative breast cancer bas.. [27]
37. Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer [27]
38. The epigenetically downregulated factor CYGB suppresses breast can.. [26]
39. Fibroblast Growth Factor Receptor 2 (FGFR2) Mutation Related Syndr.. [25]
40. Ammonium tetrathiomolybdate treatment targets the copper transport.. [25]
41. Identification of an integrated SV40 T/t-antigen cancer signature .. [24]
42. Analysis of Genomes and Transcriptomes of Hepatocellular Carcinoma.. [23]
43. PRAJA is overexpressed in glioblastoma and contributes to neural p.. [23]
44. Induction of intrahepatic cholangiocellular carcinoma by liver-spe.. [23]
45. A role of SMAD4 in iron metabolism through the positive regulation.. [23]
46. Silencing of unsynapsed meiotic chromosomes in the mouse [23]
47. Alcohol, stem cells and cancer [23]
48. PP2AC alpha deficiency impairs early cortical development through .. [23]
49. Conditional deletion of FOXL2 and SMAD4 in gonadotropes of adult m.. [22]
50. SIRT1 deacetylates TopBP1 and modulates intra-sphase checkpoint an.. [22]
51. “DNA binding region“ of BRCA1 affects genetic stability through .. [21]
52. Drug repurposing screen identifies lestaurtinib amplifies the abil.. [21]
53. A dual-specific IGF-I/II human engineered antibody domain inhibits.. [21]
54. The role of TGF-β/SMAD4 signaling in cancer [20]
55. Negative reciprocal regulation between Sirt1 and Per2 modulates th.. [20]
56. Inhibition of Estrogen Signaling Reduces the Incidence of BRCA1-as.. [19]
57. SMAD3 Regulates follicle-stimulating hormone synthesis by pituitar.. [19]
58. Fibroblast Grouth Factor Receptor (FGFR2) Mutation Related Symdrom.. [19]
59. Genomic and transcriptomic analysis reveal a driving role of TGF-b.. [18]
60. Generation of Smurf2 conditional knockout mice [18]
61. Inhibition of AKT suppresses the initiation and progression of BRC.. [18]
62. Precision Medicine for Personalized Cancer Therapy [18]
63. Smad4 is required to inhibit osteoclastogenesis and maintain bone .. [17]
64. Adapted resistance to the knockdown effect of shRNA-derived Srsf3 .. [17]
65. Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling durin.. [17]
66. SIRT1 disruption in human fetal hepatocytes leads to increased acc.. [16]
67. A mechanism for 1,4-Benzoquinone-induced genotoxicity [16]
68. Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD.. [15]
69. Postnatal deletion of Alk5 gene in meniscal cartilage accelerates .. [15]
70. Hepatic-specific disruption of SIRT6 in mice results in fatty live.. [14]
71. CRISPR-Cas9: from Genome Editing to Cancer Research [14]
72. Generation of Smurf2 conditional knockout mice [11]
73. A novel FGFR1-binding peptide exhibits anti-tumor effect on lung c.. [9]
74. SIRT3 Deacetylates ATP Synthase F1 Complex Proteins in Response to.. [7]
75. Characterization of BRCA1-deficient premalignant tissues and cance.. [7]
76. Cross-species recognition of SARS-CoV-2 to bat ACE2 [6]
77. Cisplatin prevents breast cancer metastasis through blocking early.. [6]
78. Enhanced Protein Damage Clearance Induces Broad Drug Resistance in.. [4]
79. Assessment of chimeric antigen receptor T (CAR-T) cell cytotoxicit.. [3]
80. N-glycosylation of PD-1 promotes binding of camrelizumab [1]

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