My research interests focus on the translational equivalency of model animals to human development and diseases, and the multi-omics integration analysis of human development and diseases. Heart disease is the top adult killer in the Western world and bringing a considerable health burden to the society and individuals. Understanding how the heart works from the building blocks to the whole building has clear importance not only for defining of the etiology of heart but also for discovering novel regeneration strategies to treat heart disease. Recently with the application of next generation sequencing (NGS), the bottleneck of the biomedical studies transferred from data generation to data analysis. Effectively integrating large-scale data analysis with “wet” biology is the essential way to investigate the whole system from the building bricks. I am working on the integration of genome, transcriptome, and epigenome of human and mouse to investigate the development and related diseases in human.