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REN-HE XU
Distinguished Professor
Title : Associate Dean (Research)
Distinguished Professor
Institute: Faculty of Health Sciences
Research Fields: Stem Cells and Development, Human Pluripotent Stem Cells and Derived Mesenchymal Stem Cells, Stem Cell-based Engineering and Therapy
Email: renhexu@um.edu.mo
Tel: 8822 4993
Office: (Office) E12-4015 / (Lab) N22-2003
Consultation Hours: Mon 16:00 – 18:00
Notes: --
REN-HE XU

Research Contents

We are interested in stem cell biology and application. We first discovered the key factors to sustain self-renewal and prolonged culture of human embryonic stem cells (hESCs) without the need for animal feeder cells (Nat. Biotechnol. 2002; Nat. Methods 2005; Cell Stem Cell 2008) and revealed recurrent copy number variations in human induced pluripotent stem cells (Nat. Biotechnol. 2011). We treated mouse/monkey models of multiple sclerosis, colitis (Stem Cell Reports 2014; Stem Cells 2016), osteoarthritis (Theranostics, 2019a), and skin wound (Theranostics, 2019b) with mesenchymal stem cells (MSCs) differentiated from hESCs via trophoblasts (T-MSCTM – patented) and observed superior efficacy. We also found T-MSCs enhance human fat engraftment in nude mice (Biomaterials, in press). The U.S. FDA has approved EMSCs as an Investigational New Drug (IND) for clinical trials on multiple sclerosis. In addition, we found that stem cells in spheroids can be stored under ambient conditions for a prolonged time without need for the costly and inconvenient cryopreservation (Biomaterials 2017). Our current research interests include

 

  1. Exploring novel therapeutic applications of T-MSCs;
  2. Addressing the fate, immunogenicity, and biosafety of T-MSCs;
  3. Studying the origin, development, and heterogeneity of MSCs.

Research Outputs

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