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Tzu-Ming LIU
Associate Professor
Title : Associate Professor
Institute: Faculty of Health Sciences
Research Fields: Nonlinear Optics; Tumor Microenvironment; Microscopic Pharmacokinetics of Nanomedicine; Medical Spectroscopy
Tel: 8822 4693
Office: (Office) E12-3024 / (Lab) N22-2027
Consultation Hours: Tue, Wed 10:00 – 11:00
Notes: --
Tzu-Ming LIU

Research Contents

We are biomedical optics lab using lasers for the observation of cells in vivo, the sensing of metabolic molecules, the diagnosis of diseases, and the development of medical devices. For the observation, we integrated home-build femtosecond lasers, scanning electronics, and microscopes into an in vivo microscopy system. On this platform, we studied embryonic development, tumor microenvironment, pharmacokinetics of nanomedicines, and in vivo cytometry of leukocytes. For the tracking of cells or drug delivery, we developed multiphoton contrast agents with nanomaterials like Si quantum dots, gold nanorod-in-shell, insulin-gold nanodot, iron oxide, and iron-platinum alloy. Exploiting the laser excited autofluorescence of metabolic molecules, we are developing spectroscopic methods for disease diagnosis. Through the discovery of characteristic optical properties in biomedical context, we aim to develop medical devices to solve the unmet clinical needs.


1999-09_2004-07 National Taiwan University Graduate Institute of Photonics and Optoelectronics Optics Doctor
1995-09_1999-06 National Taiwan University Department of Electrical Engineering Bachelor


2016-08_今 University of Macau Faculty of Health Sciences
2013-08_2016-08 National Taiwan University Institute of Biomedical Engineering
2012-02_2012-12 Massachusetts General Hospital Wellman Center for Photomedicine
2009-08_2013-07 National Taiwan University Institute of Biomedical Engineering

Honors & Rewards

2018-09-01 Silver prize in 2018 Guangdong Entrepreneurship and Innovation Competition Provincal The Second
2018-08-01 Third Prize of 6th Jiangsu Science & Technology Entrepreneurship Competition Provincal The Third
2018-07-01 Second Prize of Greater Bay Area (Macau) Youth Innovation and Entrepreneurship Competition Provincal The Second
2015-11-01 Potential Startup Awards Provincal The Second
2014-11-01 Outstanding Startup Awards Provincal The First


2017-03_2020-03 Metabolic imaging of macrophages in a bleeding micro-environment
2017-08_2020-08 Investigating the dynamics of melanoma angiogenesis with multiphoton in vivo microscopy
2019-01_2021-12 In vivo Imaging Flow Cytometry with High Frame-rate Plan-illuminated Harmonic Generation Microscopy
2019-06_2021-06 Pathogen detection blood fluorescence reading platform
2019-01_2022-01 Biobanking and precision oncology of several high-risk tumors in Macao and surrounding areas
2020-01_2021-12 Diagnose Acute Mesenteric Ischemia with Serum Fluorochromics
2021-06_2024-06 Label-free monitoring the apoptosis dynamics with multiphoton metabolic imaging of lipofuscin and porphyrin
2021-07_2023-07 Diagnose Diabetes Mellitus Conditions at its Early Stage with Metabolic Fluorochromic Imaging and Spectroscopy
2022-03_2025-03 Study and application of stem cell product T-MSC in promotion of diabetic wound repair
2022-03_2025-03 Cancer immunotherapy research and application based on carbon quantum dots

Research Outputs

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