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α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation Journal article
Phytomedicine, 2022,Volume: 101
Authors:  Chen, Jia Yue;  Zhu, Qi;  Cai, Cui Zan;  Luo, Hai Bin;  Lu, Jia Hong
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/05/31
Alpha-synuclein (Α-syn)  Parkinson's Disease  Phosphodiesterase 4 Inhibitor  Protein Kinase a (Pka)  Ubiquitin-proteasome System (Ups)  
Andrographolide derivative as antagonist of vitamin D receptor to induce lipidation of microtubule associate protein 1 light chain 3 (LC3) Journal article
Bioorganic and Medicinal Chemistry, 2021,Volume: 51
Authors:  Ding, Mo Yu;  Peng, Yuran;  Li, Feng;  Li, Zheng Qing;  Wang, Decai;  Zhou, Guo Chun;  Wang, Ying
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/12/08
Andrographolide Derivative  Lipidation  Microtubule Associated Protein 1 Light Chain 3  Parkinsonism  Vitamin d Receptor  
Human amyloid beta and α-synuclein co-expression in neurons impair behavior and recapitulate features for Lewy body dementia in Caenorhabditis elegans Journal article
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2021,Volume: 1867,Issue: 10
Authors:  Huang, Xiaobing;  Wang, Changliang;  Chen, Liang;  Zhang, Tianjiao;  Leung, Ka Lai;  Wong, Garry
Favorite |  | TC[WOS]:1 TC[Scopus]:2 | Submit date:2021/12/08
Amyloid β  Lewy Body Dementia  Lipid Metabolism  Lysosome Function  Α-synuclein  
Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models Journal article
Phytomedicine, 2021,Volume: 87
Authors:  Zhu, Qi;  Zhuang, Xu xu;  Chen, Jia yue;  Yuan, Ning ning;  Chen, Yan;  Cai, Cui zan;  Tan, Jie qiong;  Su, Huan xing;  Lu, Jia hong
Favorite |  | TC[WOS]:3 TC[Scopus]:4 | Submit date:2021/12/08
Camp/pka Pathway  Lycorine  Parkinson's Disease  Ubiquitin-proteasome System  Α-synuclein  
Natural alkaloid compounds as inhibitors for alpha-synuclein seeded fibril formation and toxicity Journal article
Molecules, 2021,Volume: 26,Issue: 12
Authors:  Ghanem, Simona S.;  Fayed, Hend S.;  Zhu, Qi;  Lu, Jia Hong;  Vaikath, Nishant N.;  Ponraj, Janarthanan;  Mansour, Said;  El-Agnaf, Omar M.A.
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2021/12/08
Parkinson’s Disease  Seeded Fibril Formation  Α-synuclein  
Corynoxine Protects Dopaminergic Neurons Through Inducing Autophagy and Diminishing Neuroinflammation in Rotenone-Induced Animal Models of Parkinson’s Disease Journal article
Frontiers in Pharmacology, 2021,Volume: 12
Authors:  Chen, Leilei;  Huang, Yujv;  Yu, Xing;  Lu, Jiahong;  Jia, Wenting;  Song, Juxian;  Liu, Liangfeng;  Wang, Youcui;  Huang, Yingyu;  Xie, Junxia;  Li, Min
Favorite |  | TC[WOS]:7 TC[Scopus]:10 | Submit date:2021/12/07
Autophagy  Corynoxine  Neuroinflammation  Parkinson’s Disease  Rotenone  Α-synuclein  
Dysregulation of MicroRNAs and PIWI-Interacting RNAs in a Caenorhabditis elegans Parkinson’s Disease Model Overexpressing Human α-Synuclein and Influence of tdp-1 Journal article
Frontiers in Neuroscience, 2021,Volume: 15
Authors:  Shen, Linjing;  Wang, Changliang;  Chen, Liang;  Wong, Garry
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/12/07
Caenorhabditis Elegans  Microrna  Neurodegenerative Disease  Piwi-interacting Rna  Synucleinopathies  
Targeted graphene oxide for drug delivery as a therapeutic nanoplatform against Parkinson's disease Journal article
Biomaterials Science, 2021,Volume: 9,Issue: 5,Page: 1705-1715
Authors:  Xiong, Sha;  Luo, Jingshan;  Wang, Qun;  Li, Zhongjun;  Li, Juntong;  Liu, Qiao;  Gao, Liqian;  Fang, Shuhuan;  Li, Yunyong;  Pan, Huafeng;  Wang, Hong;  Zhang, Yongbin;  Wang, Qi;  Chen, Xiaojia;  Chen, Tongkai
Favorite |  | TC[WOS]:11 TC[Scopus]:10 | Submit date:2021/12/07
Essential role for autophagy protein VMP1 in maintaining neuronal homeostasis and preventing axonal degeneration Journal article
Cell Death and Disease, 2021,Volume: 12,Issue: 1
Authors:  Wang,Panpan;  Chen,Xi;  Wang,Yuanyuan;  Jia,Congcong;  Liu,Xinyao;  Wang,Ying;  Wu,Haifeng;  Cai,Huaibin;  Shen,Han Ming;  Le,Weidong;  Wang,Panpan;  Chen,Xi;  Wang,Yuanyuan;  Jia,Congcong;  Liu,Xinyao;  Wang,Ying;  Wu,Haifeng;  Cai,Huaibin;  Shen,Han Ming;  Le,Weidong
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/03/02
TDP-1/TDP-43 potentiates human α-Synuclein (HASN) neurodegeneration in Caenorhabditis elegans Journal article
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2020,Volume: 1866,Issue: 10
Authors:  Shen,Linjing;  Wang,Changliang;  Chen,Liang;  Leung,Ka Lai;  Lo,Esther;  Lakso,Merja;  Wong,Garry
Favorite |  | TC[WOS]:7 TC[Scopus]:5 | Submit date:2021/03/02
C. Elegans  Lewy Body Dementia  Neurodegeneration  Parkinson's Disease  Tdp-1/tdp-43  Tdp-43  Α-synuclein