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A bioactive ligand-conjugated iridium(III) metal-based complex as a Keap1–Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury Journal article
Redox Biology, 2021,Volume: 48
Authors:  Li, Guodong;  Liu, Hao;  Feng, Ruibing;  Kang, Tian Shu;  Wang, Wanhe;  Ko, Chung Nga;  Wong, Chun Yuen;  Ye, Min;  Ma, Dik Lung;  Wan, Jian Bo;  Leung, Chung Hang
Favorite |  | TC[WOS]:1 TC[Scopus]:4 | Submit date：2022/05/13
Inhibitor  Iridium(III) complex  Kelch-like ECH-Associated protein 1  Liver injury  Nuclear factor E2-related factor 2  
Regulation of the NLRP3 inflammasome with natural products against chemical-induced liver injury Journal article
Pharmacological Research, 2021,Volume: 164
Authors:  Zou,Jian;  Wang,Sheng Peng;  Wang,Yi Tao;  Wan,Jian Bo
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date：2021/03/02
Acute Liver Failure  Chemical-induced Liver Injury  Inflammation  Natural Products  Nlrp3 Inflammasome  
Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice Journal article
BIOORGANIC & MEDICINAL CHEMISTRY, 2018,Volume: 26,Issue: 18,Page: 5053-5061
Authors:  Chen, Shao-Ru;  Li, Feng;  Ding, Mo-Yu;  Wang, Decai;  Zhao, Qi;  Wang, Yitao;  Zhou, Guo-Chun;  Wang, Ying
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Andrographolide  Stat3 Inhibitor  Acute Liver Damage  Inflammation  
MK2 mediates macrophage activation and acute lung injury by regulating let-7e miRNA Journal article
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2018,Volume: 315,Issue: 3,Page: L371-L381
Authors:  Wu, Yaxian;  He, Huiqiong;  Ding, Yunhe;  Liu, Sirui;  Zhang, Depeng;  Wang, Jun;  Jiang, Hongchao;  Zhang, Dan;  Sun, Lei;  Ye, Richard D.;  Qian, Feng
View | Adobe PDF | Favorite |  | TC[WOS]:20 TC[Scopus]:22 | Submit date：2018/10/30
acute lung injury  let-7e  lipopolysaccharides  macrophage  MAPK-activated protein kinase 2  miRNA  MK2  
Periplaneta americana Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Rats by Keap1/Nrf-2 Activation, Intestinal Barrier Function, and Gut Microbiota Regulation Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Ma, Xuewei;  Hu, Yichen;  Li, Xin;  Zheng, Xiaoting;  Wang, Yitao;  Zhang, Jinming;  Fu, Chaomei;  Geng, Funeng
View | Adobe PDF | Favorite |  | TC[WOS]:34 TC[Scopus]:41 | Submit date：2018/10/30
Ulcerative Colitis  Periplaneta Americana  16s Rrna  Gut Microbiota  Intestinal Immunity  
Acetaminophen-induced liver injury is attenuated in transgenic fat-1 mice endogenously synthesizing long-chain n-3 fatty acids Journal article
BIOCHEMICAL PHARMACOLOGY, 2018,Volume: 154,Page: 75-88
Authors:  Feng, Ruibing;  Wang, Yang;  Liu, Conghui;  Yan, Chunyan;  Zhang, Hang;  Su, Huanxing;  Kang, Jing X.;  Shang, Chang-Zhen;  Wan, Jim-Bo
Favorite |  | TC[WOS]:13 TC[Scopus]:16 | Submit date：2018/10/30
Acetaminophen  N-3 Polyunsaturated Fatty Acids  Hepatotoxicity  Jnk  Inflammatory  
UPLC/Q-TOFMS-Based Metabolomics Approach to Reveal the Protective Role of Other Herbs in An-Gong-Niu-Huang Wan Against the Hepatorenal Toxicity of Cinnabar and Realgar Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Xia, Fangbo;  Li, Ao;  Chai, Yushuang;  Xiao, Xiao;  Wan, Jianbo;  Li, Peng;  Wang, Yitao
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An-gong-niu-huang Wan  Cinnabar  Realgar  Metabonomics  Detoxification  Inflammation  
Identification of a rhodium(III) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells Journal article
CHEMICAL COMMUNICATIONS, 2018,Volume: 54,Issue: 20,Page: 2463-2466
Authors:  Yang, Guan-Jun;  Zhong, Hai-Jing;  Ko, Chung-Nga;  Wong, Suk-Yu;  Vellaisamy, Kasipandi;  Ye, Min;  Ma, Dik-Lung;  Leung, Chung-Hang
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Pinocembrin from Penthorum chinense Pursh suppresses hepatic stellate cells activation through a unified SIRT3-TGF-beta-Smad signaling pathway Journal article
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018,Volume: 341,Page: 38-50
Authors:  Zhou, Fayang;  Wang, Anqi;  Li, Dan;  Wang, Yitao;  Lin, Ligen
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Liver Fibrosis  Hepatic Stellate Cells  Penthorum Chinense Pursh  Pinocembrin  Sma- And Mad-related Proteins  Silent Mating Type Information Regulation 2 Homolog 3  
gamma-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction Journal article
JOURNAL OF FUNCTIONAL FOODS, 2018,Volume: 40,Page: 544-553
Authors:  Wang, Anqi;  Li, Dan;  Wang, Shengpeng;  Zhou, Fayang;  Li, Peng;  Wang, Yitao;  Lin, Ligen
View | Adobe PDF | Favorite |  | TC[WOS]:10 TC[Scopus]:12 | Submit date：2018/10/30
Gamma-mangostin  Mangosteen  Liver Oxidative Injury  Nrf2  Sirt1  Pgc-1 Alpha