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α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation Journal article
Phytomedicine, 2022,Volume: 101
Authors:  Chen, Jia Yue;  Zhu, Qi;  Cai, Cui Zan;  Luo, Hai Bin;  Lu, Jia Hong
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/05/31
Alpha-synuclein (Α-syn)  Parkinson's Disease  Phosphodiesterase 4 Inhibitor  Protein Kinase a (Pka)  Ubiquitin-proteasome System (Ups)  
Black Phosphorus-Based Nanotherapeutics to Overcome the Blood-Brain Barrier for Parkinson's Disease Conference paper
The 7th Nano Today Conference, Guangzhou, November 15-18, 2021
Authors:  Cheng, Guowang;  Luo, Jingshan;  Liu, Yao;  Chen, Xiaojia;  Wu, Zhenfeng;  Chen, Tongkai
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/08/02
Black Phosphorus Nanosheets  Blood-brain Barrier  Noninvasive Targeted Delivery  Α-synuclein  
Human amyloid beta and α-synuclein co-expression in neurons impair behavior and recapitulate features for Lewy body dementia in Caenorhabditis elegans Journal article
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2021,Volume: 1867,Issue: 10
Authors:  Huang, Xiaobing;  Wang, Changliang;  Chen, Liang;  Zhang, Tianjiao;  Leung, Ka Lai;  Wong, Garry
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2021/12/08
Amyloid β  Lewy Body Dementia  Lipid Metabolism  Lysosome Function  Α-synuclein  
Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models Journal article
Phytomedicine, 2021,Volume: 87
Authors:  Zhu, Qi;  Zhuang, Xu xu;  Chen, Jia yue;  Yuan, Ning ning;  Chen, Yan;  Cai, Cui zan;  Tan, Jie qiong;  Su, Huan xing;  Lu, Jia hong
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/12/08
Camp/pka Pathway  Lycorine  Parkinson's Disease  Ubiquitin-proteasome System  Α-synuclein  
Natural alkaloid compounds as inhibitors for alpha-synuclein seeded fibril formation and toxicity Journal article
Molecules, 2021,Volume: 26,Issue: 12
Authors:  Ghanem, Simona S.;  Fayed, Hend S.;  Zhu, Qi;  Lu, Jia Hong;  Vaikath, Nishant N.;  Ponraj, Janarthanan;  Mansour, Said;  El-Agnaf, Omar M.A.
Favorite |  | TC[WOS]:6 TC[Scopus]:5 | Submit date:2021/12/08
Parkinson’s Disease  Seeded Fibril Formation  Α-synuclein  
Targeted graphene oxide for drug delivery as a therapeutic nanoplatform against Parkinson's disease Journal article
Biomaterials Science, 2021,Volume: 9,Issue: 5,Page: 1705-1715
Authors:  Xiong, Sha;  Luo, Jingshan;  Wang, Qun;  Li, Zhongjun;  Li, Juntong;  Liu, Qiao;  Gao, Liqian;  Fang, Shuhuan;  Li, Yunyong;  Pan, Huafeng;  Wang, Hong;  Zhang, Yongbin;  Wang, Qi;  Chen, Xiaojia;  Chen, Tongkai
Favorite |  | TC[WOS]:15 TC[Scopus]:12 | Submit date:2021/12/07
Essential role for autophagy protein VMP1 in maintaining neuronal homeostasis and preventing axonal degeneration Journal article
Cell Death and Disease, 2021,Volume: 12,Issue: 1
Authors:  Wang,Panpan;  Chen,Xi;  Wang,Yuanyuan;  Jia,Congcong;  Liu,Xinyao;  Wang,Ying;  Wu,Haifeng;  Cai,Huaibin;  Shen,Han Ming;  Le,Weidong;  Wang,Panpan;  Chen,Xi;  Wang,Yuanyuan;  Jia,Congcong;  Liu,Xinyao;  Wang,Ying;  Wu,Haifeng;  Cai,Huaibin;  Shen,Han Ming;  Le,Weidong
Favorite |  | TC[WOS]:6 TC[Scopus]:7 | Submit date:2021/03/02
Oxyphylla a promotes degradation of α-synuclein for neuroprotection via activation of immunoproteasome Journal article
Aging and Disease, 2020,Volume: 11,Issue: 3,Page: 559-574
Authors:  Zhou,Hefeng;  Li,Shengnan;  Li,Chuwen;  Yang,Xuanjun;  Li,Haitao;  Zhong,Hanbing;  Lu,Jia Hong;  Lee,Simon Ming Yuen
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date:2021/03/01
Parkinson's Disease  Α-synuclein  Degradation  Proteasome  Neuroprotection  
Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts Journal article
BMC complementary medicine and therapies, 2020,Volume: 20,Issue: 1
Authors:  Ardah,Mustafa T.;  Ghanem,Simona S.;  Abdulla,Sara A.;  Lv,Guohua;  Emara,Mohamed M.;  Paleologou,Katerina E.;  Vaikath,Nishant N.;  Lu,Jia Hong;  Li,Min;  Vekrellis,Konstantinos;  Eliezer,David;  El-Agnaf,Omar M.A.
Favorite |  | TC[WOS]:14 TC[Scopus]:14 | Submit date:2021/03/02
Amyloid Fibrils  Dihydromyricetin  Parkinson’s Disease  Salvianolic Acid b  Seeded Fibril Formation  Α-synuclein  
Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation Journal article
Phytomedicine, 2019,Volume: 61
Authors:  Cai,Cui Zan;  Zhou,He Feng;  Yuan,Ning Ning;  Wu,Ming Yue;  Lee,Simon Ming Yuen;  Ren,Jiao Yan;  Su,Huan Xing;  Lu,Jin Jian;  Chen,Xiu Ping;  Li,Min;  Tan,Jie Qiong;  Lu,Jia Hong
Favorite |  | TC[WOS]:20 TC[Scopus]:21 | Submit date:2021/03/01
-synuclein  Harmine  Parkinson's Disease  Protein Kinase a  Ubiquitin-proteasome System