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Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's β-Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils Journal article
CNS Neuroscience and Therapeutics, 2015,Volume: 21,Issue: 12,Page: 953-961
Authors:  Sheng-Quan Hu;  Rui Wang;  Wei Cui;  Shing-Hung Mak;  Gang Li;  Yuan-Jia Hu;  Ming-Yuen Lee;  Yuan-Ping Pang;  Yi-Fan Han
Favorite |  | TC[WOS]:11 TC[Scopus]:11 | Submit date:2018/11/06
Alzheimer's Disease  Aβ Fibrils  Bis (Heptyl)-cognitin  Morris Water Maze  Reactive Oxygen Stress  Thioflavin t  
The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine Journal article
Journal of Pharmaceutical and Biomedical Analysis, 2008,Volume: 46,Issue: 1,Page: 75
Authors:  Yu H.;  Li W.-M.;  Kan K.K.W.;  Ho J.M.K.;  Carlier P.R.;  Pang Y.-P.;  Gu Z.-M.;  Zhong Z.;  Chan K.;  Wang Y.-T.;  Han Y.-F.
Favorite |  | TC[WOS]:34 TC[Scopus]:43 | Submit date:2018/10/30
Ache Inhibition  Bis(12)-hupyridone  Bis(7)-tacrine  Dimer  Ionization Constant  Lipophilicity  Solubility  
Preclinical characterization of intestinal absorption and metabolism of promising anti-Alzheimer's dimer bis(7)-tacrine Journal article
International Journal of Pharmaceutics, 2008,Volume: 357,Issue: 2018-01-02,Page: 85
Authors:  Zhang L.;  Yu H.;  Li W.M.;  Cheung M.C.;  Pang Y.P.;  Gu Z.M.;  Chan K.;  Wang Y.T.;  Zuo Z.;  Han Y.F.
Favorite |  | TC[WOS]:19 TC[Scopus]:20 | Submit date:2018/10/31
Bis(7)-tacrine  Intestinal Absorption  Metabolism  
Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry Journal article
BIOMEDICAL CHROMATOGRAPHY, 2008,Volume: 22,Issue: 4,Page: 414-420
Authors:  Li, Z;  Hu, Y;  Ming, LW;  Chun, CM;  Ping, PY;  Ge, L;  Tao, WY;  Zhong, Z;  Fan, HY
View | Adobe PDF | Favorite |  | TC[WOS]:0 TC[Scopus]:6 | Submit date:2018/11/01
Bis(7)-tacrine  Alzheimer's Disease  Lc-ms-ms  Rat Plasma  
Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons Journal article
JOURNAL OF PROTEOME RESEARCH, 2007,Volume: 6,Issue: 7,Page: 2435-2446
Authors:  Hongjun Fu;  Wenming Li;  Yulin Liu;  Yuanzhi Lao;  Wei Liu;  Cheng Chen;  Hua Yu;  Nelson T. K. Lee;  Donald C. Chang;  Peng Li;  Yuanping Pang;  Karl W. K. Tsim;  Mingtao Li;  Yifan Han
Favorite |  | TC[WOS]:28 TC[Scopus]:31 | Submit date:2020/03/12
Bis(7)-tacrine  Glutamate  Mitochondria  Cerebellar Granule Neurons  Two-dimensional Differential In-gel Electrophoresis  Maldi-tof/ms  
Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer’s dimer, in rat blood Journal article
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2007,Volume: 44,Issue: 5,Page: 1133-1138
Authors:  Yu, H;  Ho, JMK;  Kan, KKW;  Cheng, BWH;  Li, WM;  Zhang, L;  Lin, G;  Pang, YP;  Gu, ZM;  Chan, K;  Wang, YT;  Han, YF
View | Adobe PDF | Favorite |  | TC[WOS]:4 TC[Scopus]:5 | Submit date:2018/11/01
Bis(7)-tacrine  Dimer  Alzheimer's Disease  Hplc-ms/ms  Drug Monitoring  Pharmacokinetics