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Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease Journal article
Autophagy, 2022,Volume: 18,Issue: 3,Page: 624-642
Authors:  Tong, Benjamin Chun Kit;  Wu, Aston Jiaxi;  Huang, Alexis Shiying;  Dong, Rui;  Malampati, Sandeep;  Iyaswamy, Ashok;  Krishnamoorthi, Senthilkumar;  Sreenivasmurthy, Sravan Gopalkrishnashetty;  Zhu, Zhou;  Su, Chengfu;  Liu, Jia;  Song, Juxian;  Lu, Jia Hong;  Tan, Jieqiong;  Pan, Weidong;  Li, Min;  Cheung, King Ho
Favorite |  | TC[WOS]:5 TC[Scopus]:7 | Submit date：2022/05/17
Alzheimer Disease  Autophagy-lysosomal Pathway  Calcium Ion  Presenilin-1  Two Pore Segment Channel 2  
Full-coverage regulations of autophagy by ROS: from induction to maturation Journal article
Autophagy, 2021
Authors:  Zhou, Jing;  Li, Xin Yu;  Liu, Yu Jia;  Feng, Ji;  Wu, Yong;  Shen, Han Ming;  Lu, Guo Dong
Favorite |  | TC[WOS]:8 TC[Scopus]:6 | Submit date：2021/11/30
Atgs  Autophagy  Oxidative Regulation  Protein Thiols  Ros  
Garcinone E blocks autophagy through lysosomal functional destruction in ovarian cancer cells Journal article
World Journal of Traditional Chinese Medicine, 2021,Volume: 7,Issue: 2,Page: 209-216
Authors:  Xu, Xiao Huang;  Chen, Yu Chi;  Xu, Yu Lian;  Feng, Zhe Ling;  Liu, Qian Yu;  Guo, Xia;  Lin, Li Gen;  Lu, Jin Jian
Favorite |  | TC[WOS]:3 TC[Scopus]:1 | Submit date：2021/12/07
Anticancer  Autophagy  Garcinone e  Lysosome  Tfeb  
Aqueous Extract of Salvia miltiorrhiza Bunge-Radix Puerariae Herb Pair Attenuates Osteoporosis in Ovariectomized Rats Through Suppressing Osteoclast Differentiation Journal article
Frontiers in Pharmacology, 2021,Volume: 11
Authors:  Qin,Huan;  Zhao,Wenwen;  Jiao,Yang;  Zheng,Haoyi;  Zhang,Hao;  Jin,Jingyu;  Li,Qiu;  Chen,Xiuping;  Gao,Xia;  Han,Yantao
Favorite |  | TC[WOS]:3 TC[Scopus]:2 | Submit date：2021/03/01
Autophagy  Osteoclast Differentiation  Osteoporosis  Oxidative Stress  Salvia Miltiorrhiza Bunge-radix Puerariae  
Synthesis and biological effect of lysosome-targeting fluorescent anion transporters with enhanced anionophoric activity Journal article
Bioorganic and Medicinal Chemistry Letters, 2020,Volume: 30,Issue: 19
Authors:  Hong,Xiao Qiao;  He,Xiang Yu;  Tam,Kin Yip;  Chen,Wen Hua
Favorite |  | TC[WOS]:2 TC[Scopus]:1 | Submit date：2021/03/04
Cathepsin b Enzyme  Fluorescent Anion Transporter  Lysosomal Alkalization  Lysosome Targeting  
Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor Journal article
ACS Medicinal Chemistry Letters, 2020,Volume: 11,Issue: 4,Page: 535-540
Authors:  Xu,Jiaqian;  Zhang,Zhang;  Lin,Ligen;  Sun,Hongyan;  White,Lorenzo V.;  Ding,Ke;  Li,Zhengqiu
Favorite |  | TC[WOS]:6 TC[Scopus]:5 | Submit date：2021/03/01
Bioimaging  Chemoproteomics  Ddr1  Photoaffinity Labeling  Target Identification  
A novel dual sensitive polymer-gambogic acid conjugate: synthesis, characterization, and in vitro evaluation Journal article
NANOTECHNOLOGY, 2019,Volume: 30,Issue: 50
Authors:  Ke Song;  Zhaobo Wang;  Xue Liu;  Guolin Zhang;  Xin Wang;  DeFang Ouyang;  Mingrui Guo;  Lijiang Chen
Favorite |  | TC[WOS]:7 TC[Scopus]:4 | Submit date：2020/03/25
Polymer-drug Conjugate  Gambogic Acid  Sensitive Drug Delivery  Cathepsin b  Glutathione  
Serum amyloid A promotes LPS clearance and suppresses LPS-induced inflammation and tissue injury Journal article
EMBO REPORTS, 2018,Volume: 19,Issue: 10
Authors:  Cheng, Ni;  Liang, Yurong;  Du, Xiaoping;  Ye, Richard D.
View | Adobe PDF | Favorite |  | TC[WOS]:52 TC[Scopus]:48 | Submit date：2018/10/30
acute-phase response  inflammation  innate immunity  lipopolysaccharide  serum amyloid A  
Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer Journal article
CANCER LETTERS, 2018,Volume: 412,Page: 1-9
Authors:  Tang, Zheng-Hai;  Cao, Wen-Xiang;  Guo, Xia;  Dai, Xiao-Yang;  Lu, Jia-Hong;  Chen, Xiuping;  Zhu, Hong;  Lu, Jin-Jian
Favorite |  | TC[WOS]:21 TC[Scopus]:22 | Submit date：2018/10/30
Cepharanthine  Autophagy  Lysosome  Dacomitinib  Nsclc  
Lysosomal Ca2+ Signaling Regulates High Glucose-Mediated Interleukin-1β Secretion via Transcription Factor EB in Human Monocytic Cells Journal article
PLANT JOURNAL, 2017,Volume: 92,Issue: 3,Page: 452-468
Authors:  Hisa Hui Ling Tseng;  Chi Teng Vong;  Yiu Wa Kwan;  Simon Ming Yuen Lee;  Maggie Pui Man Hoi
Favorite |  | TC[WOS]:17 TC[Scopus]:18 | Submit date：2020/05/07
High Glucose