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Mechanism Study of the Protective Effects of Sodium Tanshinone IIA Sulfonate Against Atorvastatin-Induced Cerebral Hemorrhage in Zebrafish: Transcriptome Analysis Journal article
Frontiers in Pharmacology, 2020,Volume: 11
Authors:  Zhou,Zhong Yan;  Zhao,Wai Rong;  Xiao,Ying;  Zhang,Jing;  Tang,Jing Yi;  Lee,Simon Ming Yuen
Favorite |  | TC[WOS]:8 TC[Scopus]:5 | Submit date：2021/03/01
Atorvastatin  Carbonic Anhydrase  Cerebral Hemorrhage  Hemoglobin  Hypoxia-inducible Factor 1  na+/h+ Exchanger  Sodium Tanshinone Iia Sulfonate  Traditional Chinese Medicine  
Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish Journal article
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018,Volume: 350,Page: 32-42
Authors:  Zhou, Zhong-Yan;  Huang, Bin;  Li, Shang;  Huang, Xiao-Hui;  Tang, Jing-Yi;  Kwan, Yiu Wa;  Hoi, Pui Man;  Lee, Simon Ming-Yuen
Favorite |  | TC[WOS]:21 TC[Scopus]:19 | Submit date：2018/10/30
Sodium Tanshinone Iia Sulfonate  Salvia Miltiorrhiza  Hemorrhagic Stroke  Atorvastatin  Rock  
UPLC/Q-TOFMS-Based Metabolomics Approach to Reveal the Protective Role of Other Herbs in An-Gong-Niu-Huang Wan Against the Hepatorenal Toxicity of Cinnabar and Realgar Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Xia, Fangbo;  Li, Ao;  Chai, Yushuang;  Xiao, Xiao;  Wan, Jianbo;  Li, Peng;  Wang, Yitao
View | Adobe PDF | Favorite |  | TC[WOS]:19 TC[Scopus]:18 | Submit date：2018/10/30
An-gong-niu-huang Wan  Cinnabar  Realgar  Metabonomics  Detoxification  Inflammation  
Identification of a rhodium(III) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells Journal article
CHEMICAL COMMUNICATIONS, 2018,Volume: 54,Issue: 20,Page: 2463-2466
Authors:  Yang, Guan-Jun;  Zhong, Hai-Jing;  Ko, Chung-Nga;  Wong, Suk-Yu;  Vellaisamy, Kasipandi;  Ye, Min;  Ma, Dik-Lung;  Leung, Chung-Hang
View | Adobe PDF | Favorite |  | TC[WOS]:29 TC[Scopus]:29 | Submit date：2018/10/30
Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell–cell adhesion by inhibiting VE-cadherin internalization and actin-myosin contractility Journal article
Pharmacological Research, 2018,Volume: 128,Page: 389-398
Authors:  Huang B.;  Zhou Z.-Y.;  Li S.;  Huang X.-H.;  Tang J.-Y.;  Hoi M.P.M.;  Lee S.M.Y.
Favorite |  | TC[WOS]:11 TC[Scopus]:11 | Submit date：2018/11/06
Endothelial cell adhesion  Hemorrhagic stroke  HUVECs  Tanshinone I  Vascular integrity  Zebrafish  
Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell-cell adhesion by inhibiting. VE-cadherin internalization and actin-myosin contractility Journal article
PHARMACOLOGICAL RESEARCH, 2018,Volume: 128,Page: 389-398
Authors:  Huang, Bin;  Zhou, Zhong-Yan;  Li, Shang;  Huang, Xiao-Hui;  Tang, Jing-Yi;  Hoi, Maggie Pui Man;  Lee, Simon Ming Yuen
Favorite |  | TC[WOS]:11 TC[Scopus]:11 | Submit date：2018/10/30
Tanshinone i  Vascular Integrity  Endothelial Cell Adhesion  Hemorrhagic Stroke  Zebrafish  Huvecs  
Discovery of a ROCK inhibitor, FPND, which prevents cerebral hemorrhage through maintaining vascular integrity by interference with VE-cadherin Journal article
CELL DEATH DISCOVERY, 2017,Volume: 3
Authors:  Shang Li;  Nana Ai;  Mingyun Shen;  Yuanye Dang;  Cheong-Meng Chong;  Peichen Pan;  Yiu Wa Kwan;  Shun Wan Chan;  George Pak Heng Leung;  Maggie Pui Man Hoi;  Tingjun Hou;  Simon Ming-Yuen Lee
Favorite |  | TC[WOS]:10 TC[Scopus]:11 | Submit date：2020/01/16
Paravascular pathways contribute to vasculitis and neuroinflammation after subarachnoid hemorrhage independently of glymphatic control Journal article
Cell death & disease, 2016,Volume: 7
Authors:  Luo C.;  Yao X.;  Li J.;  He B.;  Liu Q.;  Ren H.;  Liang F.;  Li M.;  Lin H.;  Peng J.;  Yuan T.F.;  Pei Z.;  Su H.
Favorite |  | TC[WOS]:51 TC[Scopus]:48 | Submit date：2018/12/28
HIGH DOSE OF ATORVASTATIN INDUCES CEREBRAL HEMORRHAGE BY DAMAGING BLOOD VESSEL STABILITY VIA SMALL GTPASES MEDIATED SRC/VE-CADHERIN/CATENINS PATHWAYS IN HUMAN ENDOTHELIAL CELL Conference paper
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vancouver, CANADA, JUN 27-30, 2015
Authors:  Li, S.;  Hoi, P. M.;  Lee, S. M. Y.
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2020/04/15
Discovery of Novel ROCK1 Inhibitors via Integrated Virtual Screening Strategy and Bioassays Journal article
Scientific Reports, 2015,Volume: 5
Authors:  Mingyun Shen;  Sheng Tian;  Peichen Pan;  Huiyong Sun;  Dan Li;  Youyong Li;  Hefeng Zhou;  Chuwen Li;  Simon Ming-Yuen Lee;  Tingjun Hou
Favorite |  | TC[WOS]:20 TC[Scopus]:25 | Submit date：2018/11/06