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A Combinatorial CRISPR–Cas9 Screen Identifies Ifenprodil as an Adjunct to Sorafenib for Liver Cancer Treatment Journal article
Cancer Research, 2021,Volume: 81,Issue: 24,Page: 6219-6232
Authors:  Xu, Feng;  Tong, Man;  Tong, Cindy S.W.;  Chan, Becky K.C.;  Chu, Hoi Yee;  Wong, Tin Lok;  Fong, John H.C.;  Cheung, Maggie S.H.;  Mak, Kylie Hin Man;  Pardeshi, Lakhansing;  Huang, Yuanhua;  Wong, Koon Ho;  Choi, Gigi C.G.;  Ma, Stephanie;  Wong, Alan S.L.
Favorite |  | TC[WOS]:0 TC[Scopus]:1 | Submit date:2022/05/11
LigTMap: ligand and structure-based target identification and activity prediction for small molecular compounds Journal article
Journal of Cheminformatics, 2021,Volume: 13,Issue: 1
Authors:  Shaikh, Faraz;  Tai, Hio Kuan;  Desai, Nirali;  Siu, Shirley W.I.
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2021/12/09
Binding Affinity Prediction  Binding Interaction Fingerprint  Drug Repurposing  Fingerprint Similarity  Inverse Docking  Psovina  Random Forest  Target Prediction  
Screening of chemical libraries for new antifungal drugs against aspergillus fumigatus reveals sphingolipids are involved in the mechanism of action of miltefosine Journal article
mBio, 2021,Volume: 12,Issue: 4
Authors:  Dos Reis, Thaila Fernanda;  Horta, Maria Augusta Crivelente;  Colabardini, Ana Cristina;  Fernandes, Caroline Mota;  Silva, Lilian Pereira;  Bastos, Rafael Wesley;  Fonseca, Maria Vitória de Lazari;  Wang, Fang;  Martins, Celso;  Rodrigues, Márcio L.;  Pereira, Cristina Silva;  Del Poeta, Maurizio;  Wong, Koon Ho;  Goldman, Gustavo H.
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2022/05/13
Aspergillus fumigatus  Drug repurposing  Miltefosine  Sphingolipids  Transcription factor  
Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing Journal article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018,Volume: 143,Page: 1021-1027
Authors:  Wu, Ke-Jia;  Zhong, Hai-Jing;  Li, Guodong;  Liu, Chenfu;  Wang, Hui-Min David;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite |  | TC[WOS]:40 TC[Scopus]:40 | Submit date:2018/10/30
Drug Repurposing  Mitoxantrone  Nedd8  Ubiquitin  
Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer Journal article
British Journal of Pharmacology, 2014,Volume: 171,Issue: 19,Page: 4478-4489
Authors:  Wang M.;  Shim J.S.;  Li R.-J.;  Dang Y.;  He Q.;  Das M.;  Liu J.O.
Favorite |  | TC[WOS]:19 TC[Scopus]:20 | Submit date:2019/01/15
Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells Journal article
Breast Cancer Research, 2014,Volume: 16,Issue: 3
Authors:  Vazquez-Ortiz G.;  Chisholm C.;  Xu X.;  Lahusen T.J.;  Li C.;  Sakamuru S.;  Huang R.;  Thomas C.J.;  Xia M.;  Deng C.
Favorite |  | TC[WOS]:14 TC[Scopus]:15 | Submit date:2018/12/13
Recent advances in drug repositioning for the discovery of new anticancer drugs Journal article
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2014,Volume: 10,Issue: 7,Page: 654-663
Authors:  Joong Sup Shim;  Jun O. Liu
Favorite |  | TC[WOS]:232 TC[Scopus]:242 | Submit date:2019/01/24
Drug Repositioning  Drug Discovery  Cancer  Angiogenesis  Drug Screening  Drug Library  
Structure-based optimization of FDA-approved drug methylene blue as a c-myc G-quadruplex DNA stabilizer Journal article
Biochimie, 2011,Volume: 93,Issue: 6,Page: 1055-1064
Authors:  Chan D.S.-H.;  Yang H.;  Kwan M.H.-T.;  Cheng Z.;  Lee P.;  Bai L.-P.;  Jiang Z.-H.;  Wong C.-Y.;  Fong W.-F.;  Leung C.-H.;  Ma D.-L.
Favorite |  | TC[WOS]:75 TC[Scopus]:77 | Submit date:2018/11/06
c-myc G-quadruplex  FDA-approved drug  Methylene blue  Repurposing  Structure-based optimization  
Structure-based repurposing of FDA-approved drugs as TNF-α inhibitors Journal article
ChemMedChem, 2011,Volume: 6,Issue: 5,Page: 765-768
Authors:  Leung C.-H.;  Chan D.S.-H.;  Kwan M.H.-T.;  Cheng Z.;  Wong C.-Y.;  Zhu G.-Y.;  Fong W.-F.;  Ma D.-L.
Favorite |  | TC[WOS]:38 TC[Scopus]:39 | Submit date:2018/11/06
Approved drugs  Drug discovery  Inhibitors  Tumor necrosis factor  Virtual screening