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Nicotinamide promotes pancreatic differentiation through the dual inhibition of CK1 and ROCK kinases in human embryonic stem cells Journal article
Stem Cell Research and Therapy, 2021,Volume: 12,Issue: 1
Authors:  Zhang, Yumeng;  Xu, Jiaqi;  Ren, Zhili;  Meng, Ya;  Liu, Weiwei;  Lu, Ligong;  Zhou, Zhou;  Chen, Guokai
Favorite |  | TC[WOS]:3 TC[Scopus]:4 | Submit date:2021/12/09
Casein Kinase 1 (Ck1)  Human Embryonic Stem Cells  Kinase Inhibitor  Nicotinamide  Pancreatic Progenitors  Rho-associated Protein Kinase (Rock)  
Charge convertible biomimetic micellar nanoparticles for enhanced melanoma-targeted therapy through tumor cells and tumor-associated macrophages dual chemotherapy with IDO immunotherapy Journal article
Chemical Engineering Journal, 2021,Volume: 412
Authors:  Luo, Kaipei;  Lian, Yunfei;  Zhang, Min;  Yu, Hua;  Wang, Guangji;  Li, Juan
Favorite |  | TC[WOS]:6 TC[Scopus]:8 | Submit date:2021/12/07
Charge Convertible Biomimetic Nanoparticle  Combined Chemoimmunotherapy  Ido Inhibition  Immunogenic Cell Death  M2-type Tumor-associated Macrophages  
9R, the cholinesterase and amyloid beta aggregation dual inhibitor, as a multifunctional agent to improve cognitive deficit and neuropathology in the triple-transgenic Alzheimer's disease mouse model Journal article
Neuropharmacology, 2020,Volume: 181
Authors:  Ju,Yaojun;  Tam,Kin Yip
Favorite |  | TC[WOS]:3 TC[Scopus]:4 | Submit date:2021/03/04
Alzheimer's Disease  Amyloid Beta  Cholinesterase  Dual Inhibition  Multifunction  
Structure-guided discovery of a luminescent theranostic toolkit for living cancer cells and the imaging behavior effect Journal article
Chemical Science, 2020,Volume: 11,Issue: 42,Page: 11404-11412
Authors:  Wu,Chun;  Wu,Ke Jia;  Liu,Jin Biao;  Wang,Wanhe;  Leung,Chung Hang;  Ma,Dik Lung
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/03/01
An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease Journal article
ACS Chemical Neuroscience, 2020,Volume: 11,Issue: 20,Page: 3346-3357
Authors:  Ju,Yaojun;  Chakravarty,Harapriya;  Tam,Kin Yip
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2021/03/04
Alzheimer's Disease  Amyloid Beta  Cholinesterase  Dual Inhibition  
Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation Journal article
European Journal of Medicinal Chemistry, 2020,Volume: 203
Authors:  Xiang,Sichuan;  Huang,Ding;  He,Qiaolin;  Li,Jie;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/03/04
Cancer Metabolism  Cancer Proliferation  Dual Inhibitor  Lactate Dehydrogenase a  Pyruvate Dehydrogenase Kinase  
Dual targeting of cholinesterase and amyloid beta with pyridinium/isoquinolium derivatives Journal article
Drug Development Research, 2020,Volume: 81,Issue: 2,Page: 242-255
Authors:  Chakravarty,Harapriya;  Ju,Yaojun;  Chen,Wen Hua;  Tam,Kin Y.
Favorite |  | TC[WOS]:6 TC[Scopus]:7 | Submit date:2021/03/04
Acetylcholinesterase  Alzheimer's Disease  Amyloid Beta  Butyrylcholinesterase  Dual Target Inhibitor  Isoquinolinium  Pyridinium  
A dual-functional molecular strategy for in situ suppressing and visualizing of neuraminidase in aqueous solution using iridium(III) complexes Journal article
CHEMICAL COMMUNICATIONS, 2019,Volume: 55,Issue: 45,Page: 6353-6356
Authors:  Wu, C;  Wu, KJ;  Liu, JB;  Zhou, XM;  Leung, CH;  Ma, DL
Favorite |  | TC[WOS]:31 TC[Scopus]:30 | Submit date:2020/03/23
Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice Journal article
BIOORGANIC & MEDICINAL CHEMISTRY, 2018,Volume: 26,Issue: 18,Page: 5053-5061
Authors:  Chen, Shao-Ru;  Li, Feng;  Ding, Mo-Yu;  Wang, Decai;  Zhao, Qi;  Wang, Yitao;  Zhou, Guo-Chun;  Wang, Ying
View | Adobe PDF | Favorite |  | TC[WOS]:11 TC[Scopus]:12 | Submit date:2018/10/30
Andrographolide  Stat3 Inhibitor  Acute Liver Damage  Inflammation  
Discovery and preliminary SAR of 14-aryloxy-andrographolide derivatives as antibacterial agents with immunosuppressant activity Journal article
RSC ADVANCES, 2018,Volume: 8,Issue: 17,Page: 9440-9456
Authors:  Li, Feng;  Li, Xiao-Min;  Sheng, Dekuan;  Chen, Shao-Ru;  Nie, Xin;  Liu, Zhuyun;  Wang, Decai;  Zhao, Qi;  Wang, Yitao;  Wang, Ying;  Zhou, Guo-Chun
View | Adobe PDF | Favorite |  | TC[WOS]:14 TC[Scopus]:14 | Submit date:2018/10/30