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SARS-CoV-2 and the Nucleus Journal article
International Journal of Biological Sciences, 2022,Volume: 18,Issue: 12,Page: 4731-4743
Authors:  Chen, Mengqi;  Ma, Yue;  Chang, Wakam
Adobe PDF | Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/07/19
Nicotinamide promotes pancreatic differentiation through the dual inhibition of CK1 and ROCK kinases in human embryonic stem cells Journal article
Stem Cell Research and Therapy, 2021,Volume: 12,Issue: 1
Authors:  Zhang, Yumeng;  Xu, Jiaqi;  Ren, Zhili;  Meng, Ya;  Liu, Weiwei;  Lu, Ligong;  Zhou, Zhou;  Chen, Guokai
Favorite |  | TC[WOS]:5 TC[Scopus]:5 | Submit date:2021/12/09
Casein Kinase 1 (Ck1)  Human Embryonic Stem Cells  Kinase Inhibitor  Nicotinamide  Pancreatic Progenitors  Rho-associated Protein Kinase (Rock)  
Charge convertible biomimetic micellar nanoparticles for enhanced melanoma-targeted therapy through tumor cells and tumor-associated macrophages dual chemotherapy with IDO immunotherapy Journal article
Chemical Engineering Journal, 2021,Volume: 412
Authors:  Luo, Kaipei;  Lian, Yunfei;  Zhang, Min;  Yu, Hua;  Wang, Guangji;  Li, Juan
Favorite |  | TC[WOS]:9 TC[Scopus]:11 | Submit date:2021/12/07
Charge Convertible Biomimetic Nanoparticle  Combined Chemoimmunotherapy  Ido Inhibition  Immunogenic Cell Death  M2-type Tumor-associated Macrophages  
LncRNA DANCR represses Doxorubicin-induced apoptosis through stabilizing MALAT1 expression in colorectal cancer cells Journal article
Cell Death and Disease, 2021,Volume: 12,Issue: 1,Page: 24
Authors:  Xiong,Minmin;  Wu,Mengshi;  Dan Peng,;  Huang,Weijun;  Chen,Zehong;  Ke,Haoxian;  Chen,Zewen;  Song,Wu;  Zhao,Yonghua;  Xiang,Andy P.;  Zhong,Xiaomin
Adobe PDF | Favorite |  | TC[WOS]:10 TC[Scopus]:11 | Submit date:2021/03/02
Engineered exosomes: Desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies Journal article
Theranostics, 2021,Volume: 11,Issue: 18,Page: 8926-8944
Authors:  Xu, Meng;  Feng, Tao;  Liu, Bowen;  Qiu, Fen;  Xu, Youhua;  Zhao, Yonghua;  Zheng, Ying
Adobe PDF | Favorite |  | TC[WOS]:11 TC[Scopus]:12 | Submit date:2022/05/13
Administration Routes  Brain Targeting  Cerebrovascular Disease  Engineered Exosomes  Neurological Disorders  Tracking  
9R, the cholinesterase and amyloid beta aggregation dual inhibitor, as a multifunctional agent to improve cognitive deficit and neuropathology in the triple-transgenic Alzheimer's disease mouse model Journal article
Neuropharmacology, 2020,Volume: 181
Authors:  Ju,Yaojun;  Tam,Kin Yip
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/03/04
Alzheimer's Disease  Amyloid Beta  Cholinesterase  Dual Inhibition  Multifunction  
Structure-guided discovery of a luminescent theranostic toolkit for living cancer cells and the imaging behavior effect Journal article
Chemical Science, 2020,Volume: 11,Issue: 42,Page: 11404-11412
Authors:  Wu,Chun;  Wu,Ke Jia;  Liu,Jin Biao;  Wang,Wanhe;  Leung,Chung Hang;  Ma,Dik Lung
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/03/01
An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease Journal article
ACS Chemical Neuroscience, 2020,Volume: 11,Issue: 20,Page: 3346-3357
Authors:  Ju,Yaojun;  Chakravarty,Harapriya;  Tam,Kin Yip
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2021/03/04
Alzheimer's Disease  Amyloid Beta  Cholinesterase  Dual Inhibition  
Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation Journal article
European Journal of Medicinal Chemistry, 2020,Volume: 203
Authors:  Xiang,Sichuan;  Huang,Ding;  He,Qiaolin;  Li,Jie;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
Favorite |  | TC[WOS]:3 TC[Scopus]:4 | Submit date:2021/03/04
Cancer Metabolism  Cancer Proliferation  Dual Inhibitor  Lactate Dehydrogenase a  Pyruvate Dehydrogenase Kinase  
A novel isoquinolinium dual inhibitor of cholinesterases and amyloid beta aggregation mitigates neuropathological changes in a triple-transgenic mouse model of Alzheimer’s disease Journal article
ACS Chemical Neuroscience, 2020,Page: 3346-3357
Authors:  Ju, Y.;  Chakravarty, H.;  Tam, K. Y.
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/07/27
cholinesterase  amyloid beta  dual inhibition  Alzheimer’s disease