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α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation Journal article
Phytomedicine, 2022,Volume: 101
Authors:  Chen, Jia Yue;  Zhu, Qi;  Cai, Cui Zan;  Luo, Hai Bin;  Lu, Jia Hong
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/31
Alpha-synuclein (Α-syn)  Parkinson's Disease  Phosphodiesterase 4 Inhibitor  Protein Kinase a (Pka)  Ubiquitin-proteasome System (Ups)  
USP13: Multiple Functions and Target Inhibition Journal article
Frontiers in Cell and Developmental Biology, 2022,Volume: 10
Authors:  Li, Xiaolong;  Yang, Ge;  Zhang, Wenyao;  Qin, Biying;  Ye, Zifan;  Shi, Huijing;  Zhao, Xinmeng;  Chen, Yihang;  Song, Bowei;  Mei, Ziqing;  Zhao, Qi;  Wang, Feng
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/04
Deubiquitination  Disease  Inhibitor  Structure  Ubiquitin-specific Protease 13  
A “three musketeers” tactic for inclining interferon-γ as a comrade-in-arm to reinforce the synergistic-tumoricidal therapy Journal article
Nano Research, 2022,Volume: 15,Issue: 4,Page: 3458-3470
Authors:  Li, Wenxi;  Xie, Lisi;  Ju, Yi;  Zhang, Zhan;  Li, Bei;  Li, Jie;  Sang, Wei;  Wang, Guohao;  Tian, Hao;  Dai, Yunlu
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/04
Anti-pd-l1 (Apd-l1)  Ido-1 Inhibitor (Nlg919)  Interferon-γ (Ifn-γ)  Neutralization  Positive Anti-tumor Feedback Loop  Tumoricidal  
Constructing virus-like SiO: X /CeO2/VOx nanozymes for 1064 nm light-triggered mild-temperature photothermal therapy and nanozyme catalytic therapy Journal article
Nanoscale, 2022,Volume: 14,Issue: 2,Page: 361-372
Authors:  Zhao, Ruoxi;  Zhang, Rui;  Feng, Lili;  Dong, Yushan;  Zhou, Jialing;  Qu, Songnan;  Gai, Shili;  Yang, Dan;  Ding, He;  Yang, Piaoping
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/17
Immobilized Kallikrein Microreactor Based on Capillary Electrophoresis for Online Enzyme Kinetics Analysis and Inhibitor Screening Journal article
Chromatographia, 2021,Volume: 84,Issue: 12,Page: 1141-1150
Authors:  Chen, Guo Ying;  Zhang, Hao;  Zhang, Chun Yan;  Wang, Yuan;  Zhao, Cong Peng;  Chen, Hua;  Yang, Feng Qing;  Hu, Yuan Jia
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2021/12/08
Capillary Electrophoresis  Enzyme Assay  Immobilized Enzyme Microreactor  Kallikrein  Molecular Docking  
Shikonin promotes ubiquitination and degradation of cIAP1/2-mediated apoptosis and necrosis in triple negative breast cancer cells Journal article
Chinese Medicine (United Kingdom), 2021,Volume: 16,Issue: 1
Authors:  Wang,Anqi;  Liu,Jiayu;  Yang,Yuhan;  Chen,Zhejie;  Gao,Caifang;  Wang,Zhanguo;  Fu,Chaomei;  Zou,Liang;  Wang,Shengpeng
Favorite |  | TC[WOS]:3 TC[Scopus]:4 | Submit date：2021/03/02
Apoptosis  Breast Cancer  Necrosis  Shikonin  Ubiquitination  
Investigation of the interaction between Chrysoeriol and xanthine oxidase using computational and in vitro approaches Journal article
International journal of biological macromolecules, 2021,Volume: 190,Page: 463-473
Authors:  Liu, Yan;  Han, Chenggang;  Lu, Tao;  Liu, Yi;  Chen, Hao;  Yang, Can;  Tu, Yanbei;  Li, Yanfang
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date：2021/12/08
Chrysoeriol  Isothermal Titration Calorimetry  Molecular Simulations  Spectroscopy  Xanthine Oxidase  
A novel strategy for glioblastoma treatment by induction of noptosis, an NQO1-dependent necrosis Journal article
Free Radical Biology and Medicine, 2021,Volume: 166,Page: 104-115
Authors:  Zhong, Bingling;  Yu, Jie;  Hou, Ying;  Ai, Nana;  Ge, Wei;  Lu, Jin Jian;  Chen, Xiuping
Favorite |  | TC[WOS]:2 TC[Scopus]:1 | Submit date：2021/09/17
Glioblastoma  Jnk1/2  Noptosis  Nqo1  Tanshindiol b  
Adsorbed hollow fiber immobilized tyrosinase for the screening of enzyme inhibitors from Pueraria lobata extract Journal article
Journal of Pharmaceutical and Biomedical Analysis, 2021,Volume: 193
Authors:  Zhao,Cong Peng;  Yin,Shi Jun;  Chen,Guo Ying;  Wang,Yuan;  Chen,Hua;  Zhao,Jing;  Yang,Feng Qing
Favorite |  | TC[WOS]:4 TC[Scopus]:5 | Submit date：2021/03/02
Adsorbed Hollow Fibers  Enzyme Immobilization  Inhibitor Screening  Pueraria Lobata  Tyrosinase  
Characterization of thrombin/factor Xa inhibitors in Rhizoma Chuanxiong through UPLC-MS-based multivariate statistical analysis Journal article
Chinese Medicine (United Kingdom), 2020,Volume: 15,Issue: 1
Authors:  Yang,Yi Yao;  Wu,Zhao Yu;  Xia,Fang Bo;  Zhang,Hao;  Wang,Xu;  Gao,Jian Li;  Yang,Feng Qing;  Wan,Jian Bo
Favorite |  | TC[WOS]:10 TC[Scopus]:11 | Submit date：2021/03/02
Chuanxiong  Enzyme Inhibitor  Factor Xa  Molecular Docking  Multivariate Statistical Analysis  Thrombin