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In Silico Study of the Acquired Resistance Caused by the Secondary Mutations of KRAS G12C Protein Using Long Time Molecular Dynamics Simulation and Markov State Model Analysis Journal article
International Journal of Molecular Sciences, 2022,Volume: 23,Issue: 22
Authors:  Tu, Gao;  Liu, Qing;  Qiu, Yue;  Leung, Elaine Lai Han;  Yao, Xiaojun
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2023/01/31
drug resistance  KRAS G12C inhibitor  Markov state model  molecular dynamics  
Mechanistic insights into the clinical Y96D mutation with acquired resistance to AMG510 in the KRASG12C Journal article
Frontiers in Oncology, 2022,Volume: 12
Authors:  Zhuang, Haiming;  Fan, Jigang;  Li, Mingyu;  Zhang, Hao;  Yang, Xiuyan;  Lin, Ligen;  Lu, Shaoyong;  Wang, Qing;  Liu, Yaqin
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2022/09/07
Amg510  Drug Resistance  G12c  Kras  Molecular Dynamics Simulations  
Resistance looms for KRAS G12C inhibitors and rational tackling strategies Journal article
Pharmacology and Therapeutics, 2021,Volume: 229
Authors:  Zhang, Junmin;  Zhang, Juanhong;  Liu, Qing;  Fan, Xing Xing;  Leung, Elaine Lai Han;  Yao, Xiao Jun;  Liu, Liang
Favorite |  | TC[WOS]:9 TC[Scopus]:12 | Submit date:2023/01/30
Cancer  Covalent Inhibitors  Kras  Resistance  Secondary Mutations  Targeted Therapy