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Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles Journal article
Acta Pharmaceutica Sinica B, 2022,Volume: 12,Issue: 4,Page: 1688-1706
Authors:  Deng, Zhiqiang;  Dong, Yu;  Zhou, Xiaoting;  Lu, Jia Hong;  Yue, Zhenyu
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Alzheimer's disease  Autophagy  Autophagy modulators  Genetic modulation  LC3-associated phagocytosis  Microglial autophagy  Neuroinflammation  Neuronal autophagy  
The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus Journal article
Cell Discovery, 2021,Volume: 7,Issue: 1
Authors:  Peng, Chao;  Huang, Yu;  Bian, Chao;  Li, Jia;  Liu, Jie;  Zhang, Kai;  You, Xinxin;  Lin, Zhilong;  He, Yanbin;  Chen, Jieming;  Lv, Yunyun;  Ruan, Zhiqiang;  Zhang, Xinhui;  Yi, Yunhai;  Li, Yanping;  Lin, Xueqiang;  Gu, Ruobo;  Xu, Junmin;  Yang, Jia’an;  Fan, Chongxu;  Yao, Ge;  Chen, Ji Sheng;  Jiang, Hui;  Gao, Bingmiao;  Shi, Qiong
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/12/09
Human gut bacterial β-glucuronidase inhibition: An emerging approach to manage medication therapy Journal article
Biochemical Pharmacology, 2021,Volume: 190
Authors:  Wang, Panpan;  Jia, Yifei;  Wu, Rongrong;  Chen, Zhiqiang;  Yan, Ru
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Bacterial Β-glucuronidases  Drug Metabolism  Efficacy/toxicity  Inhibition  
Elevated NSD3 histone methylation activity drives squamous cell lung cancer Journal article
Nature, 2021
Authors:  Yuan,Gang;  Flores,Natasha M.;  Hausmann,Simone;  Lofgren,Shane M.;  Kharchenko,Vladlena;  Angulo-Ibanez,Maria;  Sengupta,Deepanwita;  Lu,Xiaoyin;  Czaban,Iwona;  Azhibek,Dulat;  Vicent,Silvestre;  Fischle,Wolfgang;  Jaremko,Mariusz;  Fang,Bingliang;  Wistuba,Ignacio I.;  Chua,Katrin F.;  Roth,Jack A.;  Minna,John D.;  Shao,Ning Yi;  Jaremko,Łukasz;  Mazur,Pawel K.;  Gozani,Or
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Preclinical evaluation of radiation therapy of BRCA1-associated mammary tumors using a mouse model Journal article
International Journal of Biological Sciences, 2021,Volume: 17,Issue: 3,Page: 689-701
Authors:  Cho, Eun Ju;  Kim, Jong Kwang;  Baek, Hye Jung;  Kim, Sun Eui;  Park, Eun Jung;  Choi, Bum Kyu;  Kim, Tae Hyun;  Shin, Dong Hoon;  Lim, Young Kyung;  Deng, Chu Xia;  Kim, Sang Soo
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AZD2281  BRCA1  Irradiation  Precision medicine  
Review and prospect of tissue-agnostic targeted strategies in anticancer therapies Journal article
Current Topics in Medicinal Chemistry, 2021,Volume: 21,Issue: 5,Page: 404-425
Authors:  Peng, Yu;  Tao, Hongxun;  Gao, Yuanqing;  Yang, Yuanyuan;  Chen, Zhiyong
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Anticancer therapy  Broad-spectrum anticancer targeted drugs  Cancers  Chemotherapy  Precision medicine  Tissue-agnostic targeted therapy  
Transcriptome analysis of peripheral whole blood identifies crucial lncRNAs implicated in childhood asthma Journal article
BMC Medical Genomics, 2020,Volume: 13,Issue: 1
Authors:  Zheng P.;  Huang C.;  Leng D.;  Sun B.;  Zhang X.D.
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Childhood Asthma  Deep Rna-sequencing  Long Non-coding Rnas  Transcriptome  
Machado-Joseph Deubiquitinases: From Cellular Functions to Potential Therapy Targets Journal article
Frontiers in Pharmacology, 2020,Volume: 11
Authors:  Zeng,Chenming;  Zhao,Chenxi;  Ge,Fujing;  Li,Yuekang;  Cao,Ji;  Ying,Meidan;  Lu,Jinjian;  He,Qiaojun;  Yang,Bo;  Dai,Xiaoyang;  Zhu,Hong
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Cancer Therapy  Cellular Functions  Deubiquitinase  Machado-joseph Domain-containing Proteases  Mjd Disease  
A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets Journal article
Cell Reports, 2020,Volume: 32,Issue: 6
Authors:  Zhou,Peng;  Chan,Becky K.C.;  Wan,Yuk Kei;  Yuen,Chaya T.L.;  Choi,Gigi C.G.;  Li,Xinran;  Tong,Cindy S.W.;  Zhong,Sophia S.W.;  Sun,Jieran;  Bao,Yufan;  Mak,Silvia Y.L.;  Chow,Maggie Z.Y.;  Khaw,Jien Vei;  Leung,Suet Yi;  Zheng,Zongli;  Cheung,Lydia W.T.;  Tan,Kaeling;  Wong,Koon Ho;  Chan,H. Y.Edwin;  Wong,Alan S.L.
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Cancer  Combigem  Combination Therapy  Combinatorial Genetics  Crispr  Drug Interaction  Genetic Interaction  High-throughput Screening  Neurodegeneration  Parkinson's Disease  
Activation of notch 3/c-MYC/CHOP axis regulates apoptosis and promotes sensitivity of lung cancer cells to mTOR inhibitor everolimus Journal article
Biochemical Pharmacology, 2020,Volume: 175
Authors:  Li,Ting;  Xu,Xiao Huang;  Guo,Xia;  Yuan,Tao;  Tang,Zheng Hai;  Jiang,Xiao Ming;  Xu,Yu Lian;  Zhang,Le Le;  Chen,Xiuping;  Zhu,Hong;  Shi,Jia Jie;  Lu,Jin Jian
Favorite |  | TC[WOS]:6 TC[Scopus]:8 | Submit date:2021/03/01
Lung Cancer  Notch 3  C-myc  Chop  Apoptosis