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Regulation of IFN-γ-mediated PD-L1 expression by MYC in colorectal cancer with wild-type KRAS and TP53 and its clinical implications Journal article
Frontiers in Pharmacology, 2022,Volume: 13
Authors:  Guo, Libin;  Tang, Xiaoqiong;  Wong, Sin Wa;  Guo, Anyuan;  Lin, Yao;  Kwok, Hang Fai
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2023/01/30
Anti-pd-1/pd-l1 Cancer Therapy  Ifn-γ  Kras  Myc  Pd-l1 Expression  Tp53  
The cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer Journal article
Nature Communications, 2022,Volume: 13,Issue: 1
Authors:  Wong, Chi Chun;  Wu, Jian Lin;  Ji, Fenfen;  Kang, Wei;  Bian, Xiqing;  Chen, Huarong;  Chan, Lam Shing;  Luk, Simson Tsz Yat;  Tong, Samuel;  Xu, Jiaying;  Zhou, Qiming;  Liu, Dabin;  Su, Hao;  Gou, Hongyan;  Cheung, Alvin Ho Kwan;  To, Ka Fai;  Cai, Zongwei;  Shay, Jerry W.;  Yu, Jun
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2023/01/30
In Silico Study of the Acquired Resistance Caused by the Secondary Mutations of KRAS G12C Protein Using Long Time Molecular Dynamics Simulation and Markov State Model Analysis Journal article
International Journal of Molecular Sciences, 2022,Volume: 23,Issue: 22
Authors:  Tu, Gao;  Liu, Qing;  Qiu, Yue;  Leung, Elaine Lai Han;  Yao, Xiaojun
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2023/01/31
drug resistance  KRAS G12C inhibitor  Markov state model  molecular dynamics  
Mechanistic insights into the clinical Y96D mutation with acquired resistance to AMG510 in the KRASG12C Journal article
Frontiers in Oncology, 2022,Volume: 12
Authors:  Zhuang, Haiming;  Fan, Jigang;  Li, Mingyu;  Zhang, Hao;  Yang, Xiuyan;  Lin, Ligen;  Lu, Shaoyong;  Wang, Qing;  Liu, Yaqin
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2022/09/07
Amg510  Drug Resistance  G12c  Kras  Molecular Dynamics Simulations  
Transforming primary human hepatocytes into hepatocellular carcinoma with genetically defined factors Journal article
EMBO Reports, 2022
Authors:  Jiang, Zhiwu;  Cheng, Lin;  Wu, Zhiping;  Zhou, Linfu;  Wang, Haitao;  Hong, Qilan;  Wu, Qiting;  Long, Youguo;  Huang, Yunlin;  Xu, Gaoqi;  Yao, Yao;  Tang, Zhaoyang;  Zhang, Zhenfeng;  Yang, Lili;  Luo, Wei;  Yang, Jie;  Gong, Likun;  Liu, Pentao;  Chen, Xinwen;  Cui, Shuzhong;  Zhang, Qi;  Li, Yinxiong;  Li, Peng
Favorite |  | TC[WOS]:1 TC[Scopus]:0 | Submit date:2022/05/17
Biomarkers  Hepatocellular Carcinoma  Humanized Mouse Models  Immunotherapy  Oncogenes  
One-shot high-resolution melting curve analysis for: KRAS point-mutation discrimination on a digital microfluidics platform Journal article
Lab on a Chip, 2022,Volume: 22,Issue: 3,Page: 537-549
Authors:  Li, Mingzhong;  Wan, Liang;  Law, Man Kay;  Meng, Li;  Jia, Yanwei;  Mak, Pui In;  Martins, Rui P.
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2022/03/04
Putative Factors Interfering Cell Cycle Re-Entry in Alzheimer's Disease: An Omics Study with Differential Expression Meta-Analytics and Co-Expression Profiling Journal article
Journal of Alzheimer's Disease, 2022,Volume: 85,Issue: 3,Page: 1373-1398
Authors:  Yuen, Sze Chung;  Lee, Simon Ming Yuen;  Leung, Siu Wai
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2022/05/17
Alzheimer's Disease  Cell Cycle Re-entry  Co-expression Analysis  Meta-analysis  Pagerank Algorithm  
Emodin induces apoptosis and suppresses non-small-cell lung cancer growth via downregulation of sPLA2-IIa Journal article
Phytomedicine, 2022,Volume: 95
Authors:  Zhang, Fang Yuan;  Li, Run Ze;  Xu, Cong;  Fan, Xing Xing;  Li, Jia Xin;  Meng, Wei Yu;  Wang, Xuan Run;  Liang, Tu Liang;  Guan, Xiao Xiang;  Pan, Hu Dan;  Liu, Liang;  Yao, Xiao Jun;  Wu, Qi Biao;  Leung, Elaine Lai Han
Favorite |  | TC[WOS]:6 TC[Scopus]:7 | Submit date:2023/02/03
Emodin  Nsclc  Spla2-iia  Tcm  
Resistance looms for KRAS G12C inhibitors and rational tackling strategies Journal article
Pharmacology and Therapeutics, 2021,Volume: 229
Authors:  Zhang, Junmin;  Zhang, Juanhong;  Liu, Qing;  Fan, Xing Xing;  Leung, Elaine Lai Han;  Yao, Xiao Jun;  Liu, Liang
Favorite |  | TC[WOS]:9 TC[Scopus]:12 | Submit date:2023/01/30
Cancer  Covalent Inhibitors  Kras  Resistance  Secondary Mutations  Targeted Therapy  
Expansion of Rare Cancer Cells into Tumoroids for Therapeutic Regimen and Cancer Therapy Journal article
Advanced Therapeutics, 2021,Volume: 4,Issue: 7
Authors:  Enkhbat, Myagmartsend;  Liu, Yung Chiang;  Kim, Jua;  Xu, Yanshan;  Yin, Zongyi;  Liu, Tzu Ming;  Deng, Chu Xia;  Zou, Chang;  Xie, Xi;  Li, Xiaowu;  Wang, Peng Yuan
Adobe PDF | Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2021/12/08
Assembloid  Cancer Stem Cell  Circulating Tumor Cell  Drug Screening  Microenvironment