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A synergized machine learning plus cross-species wet-lab validation approach identifies neuronal mitophagy inducers inhibiting Alzheimer disease Journal article
Autophagy, 2022,Volume: 18,Issue: 4,Page: 939-941
Authors:  Ai, Ruixue;  Zhuang, Xu Xu;  Anisimov, Alexander;  Lu, Jia Hong;  Fang, Evandro F.
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/17
Aging  Alzheimer’s Disease  Autophagy  Machine Learning  Mitophagy  
Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential Journal article
Acta Pharmaceutica Sinica B, 2022,Volume: 12,Issue: 3,Page: 1019-1040
Authors:  Zhang, Wei;  Xu, Chengchao;  Sun, Jichao;  Shen, Han Ming;  Wang, Jigang;  Yang, Chuanbin
Favorite |  | TC[WOS]:0 TC[Scopus]:1 | Submit date：2022/04/06
Alzheimer's Disease (Ad)  Amyloid Beta (Aβ) Peptides  Autophagy  Autophagy Enhancers  Autophagy–lysosomal Pathway  Mapt/tau  Mitophagy  Neurodegenerative Diseases  
Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease Journal article
Autophagy, 2022,Volume: 18,Issue: 3,Page: 624-642
Authors:  Tong, Benjamin Chun Kit;  Wu, Aston Jiaxi;  Huang, Alexis Shiying;  Dong, Rui;  Malampati, Sandeep;  Iyaswamy, Ashok;  Krishnamoorthi, Senthilkumar;  Sreenivasmurthy, Sravan Gopalkrishnashetty;  Zhu, Zhou;  Su, Chengfu;  Liu, Jia;  Song, Juxian;  Lu, Jia Hong;  Tan, Jieqiong;  Pan, Weidong;  Li, Min;  Cheung, King Ho
Favorite |  | TC[WOS]:5 TC[Scopus]:7 | Submit date：2022/05/17
Alzheimer Disease  Autophagy-lysosomal Pathway  Calcium Ion  Presenilin-1  Two Pore Segment Channel 2  
A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models Journal article
Aging Cell, 2020,Volume: 19,Issue: 2
Authors:  Song,Ju Xian;  Malampati,Sandeep;  Zeng,Yu;  Durairajan,Siva Sundara Kumar;  Yang,Chuan Bin;  Tong,Benjamin Chun Kit;  Iyaswamy,Ashok;  Shang,Wen Bin;  Sreenivasmurthy,Sravan Gopalkrishnashetty;  Zhu,Zhou;  Cheung,King Ho;  Lu,Jia Hong;  Tang,Chunzhi;  Xu,Nenggui;  Li,Min
Favorite |  | TC[WOS]:46 TC[Scopus]:47 | Submit date：2021/03/02
Alzheimer's Disease  Beta-amyloid  Curcumin Analog C1  Mapt/tau  Tfeb  
Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein Journal article
Autophagy, 2020
Authors:  Hwang，Hui Yun;  Shim，Joong Sup;  Kim，Dasol;  Kwon，Ho Jeong
Favorite |  | TC[WOS]:12 TC[Scopus]:6 | Submit date：2021/03/04
AMPK  antidepressant  darts  MAPT  MTOR  Sert  tauopathy  VDAC1