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α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation Journal article
Phytomedicine, 2022,Volume: 101
Authors:  Chen, Jia Yue;  Zhu, Qi;  Cai, Cui Zan;  Luo, Hai Bin;  Lu, Jia Hong
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/31
Alpha-synuclein (Α-syn)  Parkinson's Disease  Phosphodiesterase 4 Inhibitor  Protein Kinase a (Pka)  Ubiquitin-proteasome System (Ups)  
The phosphodiesterase-4 inhibitor, FCPR16, attenuates ischemia-reperfusion injury in rats subjected to middle cerebral artery occlusion and reperfusion Journal article
BRAIN RESEARCH BULLETIN, 2018,Volume: 137,Page: 98-106
Authors:  Chen, Jiajia;  Yu, Hui;  Zhong, Jiahong;  Feng, Hongfang;  Wang, Haitao;  Cheng, Yufang;  Zou, Zhengqiang;  Huang, Chang;  Zhou, Zhongzhen;  Zheng, Wenhua;  Xu, Jiangping
Favorite |  | TC[WOS]:21 TC[Scopus]:23 | Submit date：2018/10/30
Pde4 Inhibitor  Fcpr16  Ischemia-reperfusion Injury  Stroke  Apoptosis  Inflammation  
Roflupram, a Phosphodiesterase 4 Inhibitior, Suppresses Inflammasome Activation through Autophagy in Microglial Cells Journal article
ACS CHEMICAL NEUROSCIENCE, 2017,Volume: 8,Issue: 11,Page: 2381-2392
Authors:  You, Tingting;  Cheng, Yufang;  Zhong, Jiahong;  Bi, Bingtian;  Zeng, Bingqing;  Zheng, Wenhua;  Wang, Haitao;  Xu, Jiangping
Favorite |  | TC[WOS]:31 TC[Scopus]:34 | Submit date：2018/10/30
Phosphodiesterase 4  Roflupram  Autophagy  Inflammasome  Microglia  Neuroinflammation  
Novel phosphodiesterase 4 inhibitor FCPR03 alleviates lipopolysaccharide-induced neuroinflammation by regulation of the cAMP/PKA/CREB signaling pathway and NF-κB inhibition Journal article
Journal of Pharmacology and Experimental Therapeutics, 2017,Volume: 362,Issue: 1,Page: 67-77
Authors:  Zou Z.-Q.;  Chen J.-J.;  Feng H.-F.;  Cheng Y.-F.;  Wang H.-T.;  Zhou Z.-Z.;  Guo H.-B.;  Zheng W.;  Xu J.-P.
Favorite |  | TC[WOS]:28 TC[Scopus]:29 | Submit date：2018/12/21
Novel Phosphodiesterase 4 Inhibitor FCPR03 Alleviates Lipopolysaccharide-Induced Neuroinflammation by Regulation of the cAMP/PKA/CREB Signaling Pathway and NF-kappa B Inhibition Journal article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2017,Volume: 362,Issue: 1,Page: 67-77
Authors:  Zou, Zheng-Qiang;  Chen, Jia-Jia;  Feng, Hong-Fang;  Cheng, Yu-Fang;  Wang, Hai-Tao;  Zhou, Zhong-Zhen;  Guo, Hai-Biao;  Zheng, Wenhua;  Xu, Jiang-Ping
Favorite |  | TC[WOS]:28 TC[Scopus]:29 | Submit date：2018/10/30
Roflupram, a Phosphodiesterase Inhibitior, Suppresses Inflammasome Activation through Autophagy in Microglial Cells Journal article
ACS chemical neuroscience, 2017,Page: 1-11
Authors:  Zheng, W.
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/08/31
Phosphodiesterase 4  roflupram  autophagy  inflammasome  microglia  neuroinflammation