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α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation Journal article
Phytomedicine, 2022,Volume: 101
Authors:  Chen, Jia Yue;  Zhu, Qi;  Cai, Cui Zan;  Luo, Hai Bin;  Lu, Jia Hong
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/31
Alpha-synuclein (Α-syn)  Parkinson's Disease  Phosphodiesterase 4 Inhibitor  Protein Kinase a (Pka)  Ubiquitin-proteasome System (Ups)  
Identification of AHSA1 as a Potential Therapeutic Target for Breast Cancer: Bioinformatics Analysis and in vitro Studies Journal article
Current Cancer Drug Targets, 2022,Volume: 22,Issue: 2,Page: 142-152
Authors:  Shi, Wei;  Qi, Lu;  You, Xiong Bin;  Chen, Yu Chi;  Xu, Yu Lian;  Yu, Wei Bang;  Huang, Mu Yang;  Zhao, Hong;  Lu, Jin Jian
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/06/14
Ahsa1  Breast Cancer  Invasion  Migration  Network Pharmacology  Shenling Baizhu Powder  
Putative Factors Interfering Cell Cycle Re-Entry in Alzheimer's Disease: An Omics Study with Differential Expression Meta-Analytics and Co-Expression Profiling Journal article
Journal of Alzheimer's Disease, 2022,Volume: 85,Issue: 3,Page: 1373-1398
Authors:  Yuen, Sze Chung;  Lee, Simon Ming Yuen;  Leung, Siu Wai
Favorite |  | TC[WOS]:1 TC[Scopus]:0 | Submit date：2022/05/17
Alzheimer's Disease  Cell Cycle Re-entry  Co-expression Analysis  Meta-analysis  Pagerank Algorithm  
Shikonin promotes ubiquitination and degradation of cIAP1/2-mediated apoptosis and necrosis in triple negative breast cancer cells Journal article
Chinese Medicine (United Kingdom), 2021,Volume: 16,Issue: 1
Authors:  Wang,Anqi;  Liu,Jiayu;  Yang,Yuhan;  Chen,Zhejie;  Gao,Caifang;  Wang,Zhanguo;  Fu,Chaomei;  Zou,Liang;  Wang,Shengpeng
Favorite |  | TC[WOS]:3 TC[Scopus]:4 | Submit date：2021/03/02
Apoptosis  Breast Cancer  Necrosis  Shikonin  Ubiquitination  
Prediction of differentially expressed microRNAs in blood as potential biomarkers for Alzheimer’s disease by meta-analysis and adaptive boosting ensemble learning Journal article
Alzheimer's Research and Therapy, 2021,Volume: 13,Issue: 1
Authors:  Yuen, Sze Chung;  Liang, Xiaonan;  Zhu, Hongmei;  Jia, Yongliang;  Leung, Siu wai
Favorite |  | TC[WOS]:9 TC[Scopus]:9 | Submit date：2021/12/09
Abmda  Alzheimer’s Disease  Biomarkers  Meta-analysis  Micrornas  Neuroinflammation  Neuronal Cell Cycle Re-entry  
Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models Journal article
Phytomedicine, 2021,Volume: 87
Authors:  Zhu, Qi;  Zhuang, Xu xu;  Chen, Jia yue;  Yuan, Ning ning;  Chen, Yan;  Cai, Cui zan;  Tan, Jie qiong;  Su, Huan xing;  Lu, Jia hong
Favorite |  | TC[WOS]:3 TC[Scopus]:4 | Submit date：2021/12/08
Camp/pka Pathway  Lycorine  Parkinson's Disease  Ubiquitin-proteasome System  Α-synuclein  
A Destiny for Degradation: Interplay between Cullin-RING E3 Ligases and Autophagy Journal article
Trends in Cell Biology, 2021
Authors:  Lu,Guang;  Wang,Liming;  Zhou,Jing;  Liu,Wei;  Shen,Han Ming
Favorite |  | TC[WOS]:5 TC[Scopus]:5 | Submit date：2021/03/02
Autophagy  Cancer  Cullin-ring E3 Ligases  Mtorc1  Neddylation  Ubiquitination  
Ubiquitination Regulators Discovered by Virtual Screening for the Treatment of Cancer Journal article
Frontiers in Cell and Developmental Biology, 2021,Volume: 9
Authors:  Song, Ying Qi;  Wu, Chun;  Wu, Ke Jia;  Han, Quan Bin;  Miao, Xiang Min;  Ma, Dik Lung;  Leung, Chung Hang
Favorite |  | TC[WOS]:2 TC[Scopus]:1 | Submit date：2021/12/07
Cancer  Drug Discovery  Treatment  Ubiquitination Regulator  Virtual Screening  
Enhanced Protein Damage Clearance Induces Broad Drug Resistance in Multitype of Cancers Revealed by an Evolution Drug-Resistant Model and Genome-Wide siRNA Screening Journal article
Advanced Science, 2020,Volume: 7,Issue: 23
Authors:  Shao,Fangyuan;  Lyu,Xueying;  Miao,Kai;  Xie,Lisi;  Wang,Haitao;  Xiao,Hao;  Li,Jie;  Chen,Qiang;  Ding,Renbo;  Chen,Ping;  Xing,Fuqiang;  Zhang,Xu;  Luo,Guang Hui;  Zhu,Wenli;  Cheng,Gregory;  Lon,Ng Wai;  Martin,Scott E.;  Wang,Guanyu;  Chen,Guokai;  Dai,Yunlu;  Deng,Chu Xia
Favorite |  | TC[WOS]:3 TC[Scopus]:4 | Submit date：2021/03/02
Broad Drug Resistance  Caspase 3 Activation  Patient-derived Organoid  Proteolysis  Rnai Screening  
Acetyltanshinone IIA is more potent than lapatinib in inhibiting cell growth and degrading HER2 protein in drug-resistant HER2-positive breast cancer cells Journal article
Cancer Letters, 2020,Volume: 490,Page: 1-11
Authors:  Huang,Bin;  Yip,Wai Kien;  Wei,Na;  Luo,Kathy Qian
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date：2021/03/02
Acetyltanshinone Iia  Drug Resistance  Her2 Degradation  Her2-positive Breast Cancer