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α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation Journal article
Phytomedicine, 2022,Volume: 101
Authors:  Chen, Jia Yue;  Zhu, Qi;  Cai, Cui Zan;  Luo, Hai Bin;  Lu, Jia Hong
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/05/31
Alpha-synuclein (Α-syn)  Parkinson's Disease  Phosphodiesterase 4 Inhibitor  Protein Kinase a (Pka)  Ubiquitin-proteasome System (Ups)  
Panax notoginseng extract and total saponin suppress diet-induced obesity and endoplasmic reticulum stress in epididymal white adipose tissue in mice Journal article
Chinese Medicine, 2022,Volume: 17,Page: 75
Authors:  Tan, Yi;  Zhang, Xutao;  Zhou, Yan;  Miao, Lingchao;  Xu, Baojun;  Khan, Haroon;  Wang, Yitao;  Yu, Hua;  Cheang, Wai San
Adobe PDF | Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/06/20
Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity Journal article
Chinese Medicine, 2021,Volume: 16,Issue: 1,Page: 114
Authors:  Cheng, Yaxin;  Zhao, Yonghua;  Zheng, Ying
Adobe PDF | Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date:2021/12/08
Autoimmune Diseases  Pharmacodynamics  Pharmacology  Toxicity  Triptolide  
β-Patchoulene Ameliorates Water Transport and the Mucus Barrier in 5-Fluorouracil-Induced Intestinal Mucositis Rats via the cAMP/PKA/CREB Signaling Pathway Journal article
Frontiers in Pharmacology, 2021,Volume: 12
Authors:  Wu, Jiazhen;  Gan, Yuxuan;  Luo, Huijuan;  Xu, Nan;  Chen, Liping;  Li, Mengyao;  Guan, Fengkun;  Su, Ziren;  Lin, Zhixiu;  Xie, Jianhui;  Liu, Yuhong
Favorite |  | TC[WOS]:3 TC[Scopus]:4 | Submit date:2021/12/08
5-fluorouracil  Camp/pka/creb Pathway  Intestinal Mucositis  Water Transport  Β-patchoulene  
Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models Journal article
Phytomedicine, 2021,Volume: 87
Authors:  Zhu, Qi;  Zhuang, Xu xu;  Chen, Jia yue;  Yuan, Ning ning;  Chen, Yan;  Cai, Cui zan;  Tan, Jie qiong;  Su, Huan xing;  Lu, Jia hong
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/12/08
Camp/pka Pathway  Lycorine  Parkinson's Disease  Ubiquitin-proteasome System  Α-synuclein  
Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth Journal article
Proceedings of the National Academy of Sciences of the United States of America, 2021,Volume: 118,Issue: 14
Authors:  Deng, Zhiqiang;  Li, Xianting;  Ramirez, Marian Blanca;  Purtell, Kerry;  Choi, Insup;  Lu, Jia Hong;  Yu, Qin;  Yue, Zhenyu
Favorite |  | TC[WOS]:5 TC[Scopus]:6 | Submit date:2021/12/07
Akap11  Autophagy  Cell Survival  Mitochondrial Metabolism  Pka  
Transcriptome analysis of peripheral whole blood identifies crucial lncRNAs implicated in childhood asthma Journal article
BMC Medical Genomics, 2020,Volume: 13,Issue: 1
Authors:  Zheng P.;  Huang C.;  Leng D.;  Sun B.;  Zhang X.D.
Adobe PDF | Favorite |  | TC[WOS]:5 TC[Scopus]:5 | Submit date:2021/03/03
Childhood Asthma  Deep Rna-sequencing  Long Non-coding Rnas  Transcriptome  
Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation Journal article
Phytomedicine, 2019,Volume: 61
Authors:  Cai,Cui Zan;  Zhou,He Feng;  Yuan,Ning Ning;  Wu,Ming Yue;  Lee,Simon Ming Yuen;  Ren,Jiao Yan;  Su,Huan Xing;  Lu,Jin Jian;  Chen,Xiu Ping;  Li,Min;  Tan,Jie Qiong;  Lu,Jia Hong
Favorite |  | TC[WOS]:20 TC[Scopus]:21 | Submit date:2021/03/01
-synuclein  Harmine  Parkinson's Disease  Protein Kinase a  Ubiquitin-proteasome System  
Neuroprotective Effects of BHDPC, a Novel Neuroprotectant, on Experimental Stroke by Modulating Microglia Polarization Journal article
ACS CHEMICAL NEUROSCIENCE, 2019,Volume: 10,Issue: 5,Page: 2434-2449
Authors:  Chuwen Li;  Yaqi Bian;  Yu Feng;  Fan Tang;  Liang Wang;  Maggie Pui Man Hoi;  Dan Ma;  Chao Zhao;  Simon Ming Yuen Lee
Favorite |  | TC[WOS]:22 TC[Scopus]:22 | Submit date:2020/01/16
Bhdpc  Ischemic Stroke  Microglia  Nf-κb  Creb  Pka  
BHDPC is a novel neuroprotectant that provides anti-neuroinflammatory and neuroprotective effects by inactivating NF-κB and activating PKA/CREB Journal article
Frontiers in Pharmacology, 2018,Volume: 9,Issue: JUN
Authors:  Li C.;  Chen T.;  Zhou H.;  Feng Y.;  Hoi M.P.M.;  Ma D.;  Zhao C.;  Zheng Y.;  Lee S.M.Y.
Favorite |  | TC[WOS]:12 TC[Scopus]:14 | Submit date:2018/11/06
BHDPC  CREB  Microglia  Neuroinflammation  NF-κB  PKA