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Red yeast rice ameliorates non-alcoholic fatty liver disease through inhibiting lipid synthesis and NF-κB/NLRP3 inflammasome-mediated hepatic inflammation in mice Journal article
Chinese Medicine (United Kingdom), 2022,Volume: 17,Issue: 1
Authors:  Zou, Jian;  Yan, Chunyan;  Wan, Jian Bo
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/13
Lipid synthesis  NAFLD  NF-κB  NLRP3 inflammasome  Red yeast rice  
Synthesis and pharmacological validation of fluorescent diarylsulfonylurea analogues as NLRP3 inhibitors and imaging probes Journal article
European Journal of Medicinal Chemistry, 2022,Volume: 237
Authors:  Zhao, Jiannan;  Li, Yongling;  Ma, Jing;  Liu, Jingting;  Xiao, Ruoxuan;  Wang, Linlin;  Li, Peng;  He, Yinyan;  Qian, Feng;  Zhang, Ao;  Sun, Zhen Liang;  Ding, Chunyong
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/13
Fluorescence imaging  Inflammasome  Inhibitor  NLRP3  Sulfonylurea  
Treponema primitia α1–2-fucosyltransferase-catalyzed one-pot multienzyme synthesis of fucosylated oligosaccharide lacto-N-fucopentaose I with antiviral activity against enterovirus 71 Journal article
Food Chemistry: X, 2022,Volume: 14
Authors:  Liu, Yuanyuan;  Tong, Aijun;  Gao, Xiaoxiang;  Yuan, Sinan;  Zhong, Ruting;  Zhao, Chao
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/13
Anti-enterovirus 71  Lacto-N-fucopentaose I  One-pot multienzyme synthesis  Treponema primitia α 1–2-fucosyltransferase  
Structure-Activity Relationship Studies of 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin-2-amine (FPMINT) Analogues as Inhibitors of Human Equilibrative Nucleoside Transporters Journal article
Frontiers in Pharmacology, 2022,Volume: 13
Authors:  Li, Renkai;  Mak, Winston Wing Shum;  Li, Jingjing;  Zheng, Chengwen;  Shiu, Polly Ho Ting;  Seto, Sai Wang;  Lee, Simon Ming Yuen;  Leung, George Pak Heng
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/17
equilibrative nucleoside transporter  FPMINT  inhibitor  mechanism of action  structure-activity relationship  
Simultaneous blocking of the pan-RAF and S100B pathways as a synergistic therapeutic strategy against malignant melanoma Journal article
Journal of Cellular and Molecular Medicine, 2021,Volume: 25,Issue: 4,Page: 1972-1981
Authors:  Wu,Ke Jia;  Ho,Shih Hsin;  Wu,Chun;  Wang,Hui Min D.;  Ma,Dik Lung;  Leung,Chung Hang
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date：2021/03/01
Drug Discovery  Malignant Melanoma  Pan-raf  S100b-p53 Interaction  Synergistic  
β-patchoulene improves lipid metabolism to alleviate non-alcoholic fatty liver disease via activating AMPK signaling pathway Journal article
Biomedicine and Pharmacotherapy, 2021,Volume: 134
Authors:  Xu, Nan;  Luo, Huijuan;  Li, Minyao;  Wu, Jiazhen;  Wu, Xue;  Chen, Liping;  Gan, Yuxuan;  Guan, Fengkun;  Li, Mengyao;  Su, Ziren;  Chen, Jiannan;  Liu, Yuhong
Favorite |  | TC[WOS]:2 TC[Scopus]:4 | Submit date：2021/12/07
Amp-activated Protein Kinase  Hepatic Steatosis  Non-alcoholic Fatty Liver Disease  Pogostemon Cablin  Β-patchoulene  
Licochalcone A inhibits interferon-gamma-induced programmed death-ligand 1 in lung cancer cells Journal article
Phytomedicine, 2021,Volume: 80
Authors:  Yuan,Luo Wei;  Jiang,Xiao Ming;  Xu,Yu Lian;  Huang,Mu Yang;  Chen,Yu Chi;  Yu,Wei Bang;  Su,Min Xia;  Ye,Zi Han;  Chen,Xiuping;  Wang,Yitao;  Lu,Jin Jian
Favorite |  | TC[WOS]:5 TC[Scopus]:7 | Submit date：2021/03/01
Ifn-γ  Licochalcone a  Natural Products  Pd-l1  Protein Synthesis Inhibitor  Ros  
Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity Journal article
Acta Pharmacologica Sinica, 2020,Volume: 41,Issue: 5,Page: 698-705
Authors:  Zhang,Le le;  Guo,Jing;  Jiang,Xiao ming;  Chen,Xiu ping;  Wang,Yi tao;  Li,Ao;  Lin,Li gen;  Li,Hua;  Lu,Jin jian
Favorite |  | TC[WOS]:12 TC[Scopus]:12 | Submit date：2021/03/01
Nagilactone e  Diterpenoids  Human Lung Cancer A549 Cell Line Xenograft  Rna-seq  Cmap  Click-it  Molecular Docking  Riok2  Protein Synthesis Inhibitor  
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice Journal article
ACTA PHARMACOLOGICA SINICA, 2019,Volume: 40,Issue: 9,Page: 1193-1204
Authors:  Ting-ting Zhou;  Tong Zhao;  Fei Ma;  Yi-nan Zhang;  Jing Jiang;  Yuan Ruan;  Qiu-ying Yan;  Gai-hong Wang;  Jin Ren;  Xiao-wei Guan;  Jun Guo;  Yong-hua Zhao;  Ji-ming Ye;  Li-hong Hu;  Jing Chen;  Xu Shen
Favorite |  | TC[WOS]:4 TC[Scopus]:5 | Submit date：2020/04/14
Type 2 Diabetes Mellitus  Hepatic Gluconeogenesis  Ampk Signaling Pathway  (e)-3-(2-(Quinoline-4-yl)Vinyl)-1h-indol-6-ol (Qvo)  4-[2-(1h-indol-3-yl)Vinyl]Quinoline (Ivq)  Prodrug  
Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice Journal article
BIOORGANIC & MEDICINAL CHEMISTRY, 2018,Volume: 26,Issue: 18,Page: 5053-5061
Authors:  Chen, Shao-Ru;  Li, Feng;  Ding, Mo-Yu;  Wang, Decai;  Zhao, Qi;  Wang, Yitao;  Zhou, Guo-Chun;  Wang, Ying
View | Adobe PDF | Favorite |  | TC[WOS]:11 TC[Scopus]:12 | Submit date：2018/10/30
Andrographolide  Stat3 Inhibitor  Acute Liver Damage  Inflammation