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Red yeast rice ameliorates non-alcoholic fatty liver disease through inhibiting lipid synthesis and NF-κB/NLRP3 inflammasome-mediated hepatic inflammation in mice
Journal article
Chinese Medicine (United Kingdom), 2022,Volume: 17,Issue: 1
Authors:
Zou, Jian
;
Yan, Chunyan
;
Wan, Jian Bo
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TC[WOS]:
0
TC[Scopus]:
0
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Submit date:2022/05/13
Lipid synthesis
NAFLD
NF-κB
NLRP3 inflammasome
Red yeast rice
Synthesis and pharmacological validation of fluorescent diarylsulfonylurea analogues as NLRP3 inhibitors and imaging probes
Journal article
European Journal of Medicinal Chemistry, 2022,Volume: 237
Authors:
Zhao, Jiannan
;
Li, Yongling
;
Ma, Jing
;
Liu, Jingting
;
Xiao, Ruoxuan
;
Wang, Linlin
;
Li, Peng
;
He, Yinyan
;
Qian, Feng
;
Zhang, Ao
;
Sun, Zhen Liang
;
Ding, Chunyong
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TC[WOS]:
0
TC[Scopus]:
0
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Submit date:2022/05/13
Fluorescence imaging
Inflammasome
Inhibitor
NLRP3
Sulfonylurea
Treponema primitia α1–2-fucosyltransferase-catalyzed one-pot multienzyme synthesis of fucosylated oligosaccharide lacto-N-fucopentaose I with antiviral activity against enterovirus 71
Journal article
Food Chemistry: X, 2022,Volume: 14
Authors:
Liu, Yuanyuan
;
Tong, Aijun
;
Gao, Xiaoxiang
;
Yuan, Sinan
;
Zhong, Ruting
;
Zhao, Chao
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TC[WOS]:
0
TC[Scopus]:
0
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Submit date:2022/05/13
Anti-enterovirus 71
Lacto-N-fucopentaose I
One-pot multienzyme synthesis
Treponema primitia α 1–2-fucosyltransferase
Structure-Activity Relationship Studies of 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin-2-amine (FPMINT) Analogues as Inhibitors of Human Equilibrative Nucleoside Transporters
Journal article
Frontiers in Pharmacology, 2022,Volume: 13
Authors:
Li, Renkai
;
Mak, Winston Wing Shum
;
Li, Jingjing
;
Zheng, Chengwen
;
Shiu, Polly Ho Ting
;
Seto, Sai Wang
;
Lee, Simon Ming Yuen
;
Leung, George Pak Heng
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TC[WOS]:
0
TC[Scopus]:
0
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Submit date:2022/05/17
equilibrative nucleoside transporter
FPMINT
inhibitor
mechanism of action
structure-activity relationship
Simultaneous blocking of the pan-RAF and S100B pathways as a synergistic therapeutic strategy against malignant melanoma
Journal article
Journal of Cellular and Molecular Medicine, 2021,Volume: 25,Issue: 4,Page: 1972-1981
Authors:
Wu,Ke Jia
;
Ho,Shih Hsin
;
Wu,Chun
;
Wang,Hui Min D.
;
Ma,Dik Lung
;
Leung,Chung Hang
Favorite
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TC[WOS]:
2
TC[Scopus]:
2
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Submit date:2021/03/01
Drug Discovery
Malignant Melanoma
Pan-raf
S100b-p53 Interaction
Synergistic
β-patchoulene improves lipid metabolism to alleviate non-alcoholic fatty liver disease via activating AMPK signaling pathway
Journal article
Biomedicine and Pharmacotherapy, 2021,Volume: 134
Authors:
Xu, Nan
;
Luo, Huijuan
;
Li, Minyao
;
Wu, Jiazhen
;
Wu, Xue
;
Chen, Liping
;
Gan, Yuxuan
;
Guan, Fengkun
;
Li, Mengyao
;
Su, Ziren
;
Chen, Jiannan
;
Liu, Yuhong
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TC[WOS]:
2
TC[Scopus]:
4
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Submit date:2021/12/07
Amp-activated Protein Kinase
Hepatic Steatosis
Non-alcoholic Fatty Liver Disease
Pogostemon Cablin
Β-patchoulene
Licochalcone A inhibits interferon-gamma-induced programmed death-ligand 1 in lung cancer cells
Journal article
Phytomedicine, 2021,Volume: 80
Authors:
Yuan,Luo Wei
;
Jiang,Xiao Ming
;
Xu,Yu Lian
;
Huang,Mu Yang
;
Chen,Yu Chi
;
Yu,Wei Bang
;
Su,Min Xia
;
Ye,Zi Han
;
Chen,Xiuping
;
Wang,Yitao
;
Lu,Jin Jian
Favorite
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TC[WOS]:
5
TC[Scopus]:
7
|
Submit date:2021/03/01
Ifn-γ
Licochalcone a
Natural Products
Pd-l1
Protein Synthesis Inhibitor
Ros
Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity
Journal article
Acta Pharmacologica Sinica, 2020,Volume: 41,Issue: 5,Page: 698-705
Authors:
Zhang,Le le
;
Guo,Jing
;
Jiang,Xiao ming
;
Chen,Xiu ping
;
Wang,Yi tao
;
Li,Ao
;
Lin,Li gen
;
Li,Hua
;
Lu,Jin jian
Favorite
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TC[WOS]:
12
TC[Scopus]:
12
|
Submit date:2021/03/01
Nagilactone e
Diterpenoids
Human Lung Cancer A549 Cell Line Xenograft
Rna-seq
Cmap
Click-it
Molecular Docking
Riok2
Protein Synthesis Inhibitor
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice
Journal article
ACTA PHARMACOLOGICA SINICA, 2019,Volume: 40,Issue: 9,Page: 1193-1204
Authors:
Ting-ting Zhou
;
Tong Zhao
;
Fei Ma
;
Yi-nan Zhang
;
Jing Jiang
;
Yuan Ruan
;
Qiu-ying Yan
;
Gai-hong Wang
;
Jin Ren
;
Xiao-wei Guan
;
Jun Guo
;
Yong-hua Zhao
;
Ji-ming Ye
;
Li-hong Hu
;
Jing Chen
;
Xu Shen
Favorite
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TC[WOS]:
4
TC[Scopus]:
5
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Submit date:2020/04/14
Type 2 Diabetes Mellitus
Hepatic Gluconeogenesis
Ampk Signaling Pathway
(e)-3-(2-(Quinoline-4-yl)Vinyl)-1h-indol-6-ol (Qvo)
4-[2-(1h-indol-3-yl)Vinyl]Quinoline (Ivq)
Prodrug
Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice
Journal article
BIOORGANIC & MEDICINAL CHEMISTRY, 2018,Volume: 26,Issue: 18,Page: 5053-5061
Authors:
Chen, Shao-Ru
;
Li, Feng
;
Ding, Mo-Yu
;
Wang, Decai
;
Zhao, Qi
;
Wang, Yitao
;
Zhou, Guo-Chun
;
Wang, Ying
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TC[WOS]:
11
TC[Scopus]:
12
|
Submit date:2018/10/30
Andrographolide
Stat3 Inhibitor
Acute Liver Damage
Inflammation