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Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity Journal article
European Journal of Medicinal Chemistry, 2021,Volume: 214
Authors:  Xu,Biao;  Wang,Zhi Peng;  Liu,Qingwang;  Yang,Xiaohong;  Li,Xuemin;  Huang,Ding;  Qiu,Yanfei;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
Favorite |  | TC[WOS]:0 TC[Scopus]:1 | Submit date:2021/03/04
Cancer metabolism  Proliferation  Pyruvate dehydrogenase kinase  Structure-activity relationship  
Function of DHX33 in promoting Warburg effect via regulation of glycolytic genes Journal article
Journal of Cellular Physiology, 2021,Volume: 236,Issue: 2,Page: 981-996
Authors:  Peng,Cheng;  Hou,Sheng Tao;  Deng,Chu Xia;  Zhang,Yandong
Favorite |  | TC[WOS]:1 TC[Scopus]:0 | Submit date:2021/03/02
demethylation  DHX33  Gadd45a  glycolysis  RNA helicase  Warburg effect  
Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation Journal article
European Journal of Medicinal Chemistry, 2020,Volume: 203
Authors:  Xiang,Sichuan;  Huang,Ding;  He,Qiaolin;  Li,Jie;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/03/04
Cancer metabolism  Cancer proliferation  Dual inhibitor  Lactate dehydrogenase A  Pyruvate dehydrogenase kinase  
Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke Journal article
FRONTIERS IN PHARMACOLOGY, 2019,Volume: 10
Authors:  Cheng Luo;  Xiqing Bian;  Qian Zhang;  Zhenyan Xia;  Bowen Liu;  Qi Chen;  Chienchih Ke;  Jian-Lin Wu;  Yonghua Zhao
Favorite |  | TC[WOS]:9 TC[Scopus]:9 | Submit date:2020/04/14
Cerebral Energy Deficiency  Citrate Cycle  Diaaa Derivatization-uhplc-q-tof/ms  Ischemic Stroke  Shengui Sansheng San  
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
Bioorganic and Medicinal Chemistry Letters, 2018,Volume: 28,Issue: 21,Page: 3441-3445
Authors:  Zhang,Shao Lin;  Yang,Zheng;  Hu,Xiaohui;  Tam,Kin Yip
Favorite |  | TC[WOS]:5 TC[Scopus]:6 | Submit date:2021/03/04
Antiproliferative activity  Dichloroacetophenone  Kinase inhibition  Pyruvate dehydrogenase complex  Pyruvate dehydrogenase kinase  
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018,Volume: 28,Issue: 21,Page: 3441-3445
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
Favorite |  | TC[WOS]:5 TC[Scopus]:6 | Submit date:2018/10/30
Pyruvate dehydrogenase kinase  Pyruvate dehydrogenase complex  Antiproliferative activity  Dichloroacetophenone  Kinase inhibition  
Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics Journal article
ACS Combinatorial Science, 2018,Volume: 20,Issue: 11,Page: 660-671
Authors:  Zhang W.;  Hu X.;  Chakravarty H.;  Yang Z.;  Tam K.Y.
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2018/12/18
cancer  high-throughput screening  pyruvate dehydrogenase kinase 1  small molecule inhibitors  Warburg effect  
Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 838,Page: 41-52
Authors:  Yang, Zheng;  Zhang, Shao-Lin;  Hu, Xiaohui;  Tam, Kin Yip
Favorite |  | TC[WOS]:12 TC[Scopus]:11 | Submit date:2018/10/30
Dichloroacetophenone  Epidermal Growth Factor Receptor  Tyrosine Kinase Inhibitor  Synergism  Hypoxia  Oxidative Phosphorylation  
Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1 Journal article
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018,Volume: 123,Page: 43-55
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Chakravarty, Harapriya;  Tam, Kin Yip
Favorite |  | TC[WOS]:7 TC[Scopus]:8 | Submit date:2018/10/30
Dichloroacetophenone  Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Anticancer Activity  Metabolic Reprogramming  
Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors Journal article
JOURNAL OF PROTEOME RESEARCH, 2018,Volume: 17,Issue: 9,Page: 3012-3021
Authors:  Zhang, Wen;  Hu, Xiaohui;  Zhou, Wei;  Tam, Kin Yip
Favorite |  | TC[WOS]:8 TC[Scopus]:6 | Submit date:2018/10/30
Aerobic Glycolysis  Azd7545  Dichloroacetate  Lc-ms/ms  Pyruvate Dehydrogenase Kinases  Cancer Metabolism