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α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation Journal article
Phytomedicine, 2022,Volume: 101
Authors:  Chen, Jia Yue;  Zhu, Qi;  Cai, Cui Zan;  Luo, Hai Bin;  Lu, Jia Hong
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/05/31
Alpha-synuclein (Α-syn)  Parkinson's Disease  Phosphodiesterase 4 Inhibitor  Protein Kinase a (Pka)  Ubiquitin-proteasome System (Ups)  
USP13: Multiple Functions and Target Inhibition Journal article
Frontiers in Cell and Developmental Biology, 2022,Volume: 10
Authors:  Li, Xiaolong;  Yang, Ge;  Zhang, Wenyao;  Qin, Biying;  Ye, Zifan;  Shi, Huijing;  Zhao, Xinmeng;  Chen, Yihang;  Song, Bowei;  Mei, Ziqing;  Zhao, Qi;  Wang, Feng
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/05/04
Deubiquitination  Disease  Inhibitor  Structure  Ubiquitin-specific Protease 13  
USP15 in Cancer and Other Diseases: From Diverse Functionsto Therapeutic Targets Journal article
Biomedicines, 2022,Volume: 10,Issue: 2
Authors:  Li, Yan Chi;  Cai, Song Wang;  Shu, Yu Bin;  Chen, Mei Wan;  Shi, Zhi
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/03/04
Cancer  Deubiquitinatase  Target  Ubiquitin  Usp15  
Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition Journal article
Phytomedicine, 2022,Volume: 96
Authors:  Sreenivasmurthy, Sravan Gopalkrishnashetty;  Iyaswamy, Ashok;  Krishnamoorthi, Senthilkumar;  Senapati, Sanjib;  Malampati, Sandeep;  Zhu, Zhou;  Su, Cheng Fu;  Liu, Jia;  Guan, Xin Jie;  Tong, Benjamin Chun Kit;  Cheung, King Ho;  Tan, Jie Qiong;  Lu, Jia Hong;  Durairajan, Siva Sundara Kumar;  Song, Ju Xian;  Li, Min
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3xtg-ad Mice  Alzheimer's Disease  Hdac6  P301s-tau Mice  Phospho-tau  Protopine  
Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice Journal article
Bone Research, 2022,Volume: 10,Issue: 1
Authors:  Wang, Zuqiang;  Chen, Hangang;  Tan, Qiaoyan;  Huang, Junlan;  Zhou, Siru;  Luo, Fengtao;  Zhang, Dali;  Yang, Jing;  Li, Can;  Chen, Bo;  Sun, Xianding;  Kuang, Liang;  Jiang, Wanling;  Ni, Zhenhong;  Wang, Quan;  Chen, Shuai;  Du, Xiaolan;  Chen, Di;  Deng, Chuxia;  Yin, Liangjun;  Chen, Lin;  Xie, Yangli
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Curcumin prevents As3+-induced carcinogenesis through regulation of GSK3β/Nrf2 Journal article
Chinese Medicine (United Kingdom), 2021,Volume: 16,Issue: 1
Authors:  Dang, Yuan Ye;  Luo, Hua;  Li, Yong Mei;  Zhou, Yang;  Luo, Xiu;  Lin, Shui Mu;  Liu, Shou Ping;  Lee, Simon Ming Yuen;  Li, Chu Wen;  Dai, Xiao Yan
Favorite |  | TC[WOS]:0 TC[Scopus]:1 | Submit date:2021/12/08
Arsenic  Autophagy  Carcinogenesis  Curcumin  Gsk-3β/β-trcp  Nrf2  Ros  
Prediction of differentially expressed microRNAs in blood as potential biomarkers for Alzheimer’s disease by meta-analysis and adaptive boosting ensemble learning Journal article
Alzheimer's Research and Therapy, 2021,Volume: 13,Issue: 1
Authors:  Yuen, Sze Chung;  Liang, Xiaonan;  Zhu, Hongmei;  Jia, Yongliang;  Leung, Siu wai
Favorite |  | TC[WOS]:9 TC[Scopus]:9 | Submit date:2021/12/09
Abmda  Alzheimer’s Disease  Biomarkers  Meta-analysis  Micrornas  Neuroinflammation  Neuronal Cell Cycle Re-entry  
Nannocystin ax, an eEF1A inhibitor, induces G1 cell cycle arrest and caspase-independent apoptosis through cyclin D1 downregulation in colon cancer in vivo Journal article
Pharmacological Research, 2021,Volume: 173
Authors:  Hou, Ying;  Liu, Rong;  Xia, Mengwei;  Sun, Chong;  Zhong, Bingling;  Yu, Jie;  Ai, Nana;  Lu, Jin Jian;  Ge, Wei;  Liu, Bo;  Chen, Xiuping
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Apoptosis  Cyclin D1  G1 Cell Cycle Arrest  Nannocystin Ax  
Small molecules targeting ubiquitination to control inflammatory diseases Journal article
Drug Discovery Today, 2021,Volume: 26,Issue: 10,Page: 2414-2422
Authors:  Li, Zheng Qing;  Chen, Xiuping;  Wang, Ying
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Inflammatory Diseases  Small Molecule Modulator  Ubiquitin  Ubiquitination System  
Full-coverage regulations of autophagy by ROS: from induction to maturation Journal article
Autophagy, 2021
Authors:  Zhou, Jing;  Li, Xin Yu;  Liu, Yu Jia;  Feng, Ji;  Wu, Yong;  Shen, Han Ming;  Lu, Guo Dong
Favorite |  | TC[WOS]:8 TC[Scopus]:6 | Submit date:2021/11/30
Atgs  Autophagy  Oxidative Regulation  Protein Thiols  Ros