UM

Browse/Search Results:  1-10 of 56 Help

Selected(0)Clear Items/Page:    Sort:
Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm Journal article
Acta Pharmaceutica Sinica B, 2022
Authors:  Wang, Wei;  Feng, Shuo;  Ye, Zhuyifan;  Gao, Hanlu;  Lin, Jinzhong;  Ouyang, Defang
Favorite |  | TC[WOS]:0 TC[Scopus]:1 | Submit date:2022/05/17
Formulation prediction  Ionizable lipid  LightGBM  Lipid nanoparticle  Machine learning  Molecular modeling  mRNA  Vaccine  
PharmSD: A novel AI-based computational platform for solid dispersion formulation design Journal article
International Journal of Pharmaceutics, 2021,Volume: 604
Authors:  Dong, Jie;  Gao, Hanlu;  Ouyang, Defang
Favorite |  | TC[WOS]:1 TC[Scopus]:4 | Submit date:2021/12/08
Computational Platform  Drug Design  Formulation  Machine Learning  Solid Dispersion  Web Server  
ChemGenerator: A web server for generating potential ligands for specific targets Journal article
Briefings in Bioinformatics, 2021,Volume: 22,Issue: 4
Authors:  Yang, Jing;  Hou, Ling;  Liu, Kun Meng;  He, Wen Bin;  Cai, Yong;  Yang, Feng Qing;  Hu, Yuan Jia
Favorite |  | TC[WOS]:0 TC[Scopus]:2 | Submit date:2021/12/08
Autoencoder  Deep Learning  Long Short-term Memory (Lstm)  Molecular Generation  Web Server  
Ubiquitination Regulators Discovered by Virtual Screening for the Treatment of Cancer Journal article
Frontiers in Cell and Developmental Biology, 2021,Volume: 9
Authors:  Song, Ying Qi;  Wu, Chun;  Wu, Ke Jia;  Han, Quan Bin;  Miao, Xiang Min;  Ma, Dik Lung;  Leung, Chung Hang
Favorite |  | TC[WOS]:2 TC[Scopus]:1 | Submit date:2021/12/07
Cancer  Drug Discovery  Treatment  Ubiquitination Regulator  Virtual Screening  
GWOVina: A grey wolf optimization approach to rigid and flexible receptor docking Journal article
Chemical Biology and Drug Design, 2021,Volume: 97,Issue: 1,Page: 97-110
Authors:  Wong, Kin Meng;  Tai, Hio Kuan;  Siu, Shirley W.I.
Favorite |  | TC[WOS]:3 TC[Scopus]:4 | Submit date:2021/12/07
Autodock Vina  Gwovina  Nature-inspired Algorithm  Protein–ligand Docking  Side-chain Flexibility  Structure-based Drug Design  Swarm Intelligence  
Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells Journal article
Genes and Diseases, 2021
Authors:  Cheng, Shasha;  Yang, Guan Jun;  Wang, Wanhe;  Ma, Dik Lung;  Leung, Chung Hang
Favorite |  | TC[WOS]:0 TC[Scopus]:3 | Submit date:2022/05/13
Cancer stem cells  CDK9-cyclin T1  Epithelial mesenchymal transition  Protein–protein interaction (PPI)  Triple-negative breast cancer (TNBC)  
A 7-methoxybicoumarin derivative selectively inhibits BRD4 BD2 for anti-melanoma therapy Journal article
International Journal of Biological Macromolecules, 2020,Volume: 164,Page: 3204-3220
Authors:  Yang,Guan Jun;  Wang,Wanhe;  Lei,Pui Man;  Leung,Chung Hang;  Ma,Dik Lung
Favorite |  | TC[WOS]:6 TC[Scopus]:7 | Submit date:2021/03/01
Brd4  BromoDomain Domain  Cell Metastasis And Invasion  Histone Acetylation  Melanoma  Protein–protein Interaction  Virtual Screening  
Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation Journal article
European Journal of Medicinal Chemistry, 2020,Volume: 203
Authors:  Xiang,Sichuan;  Huang,Ding;  He,Qiaolin;  Li,Jie;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/03/04
Cancer Metabolism  Cancer Proliferation  Dual Inhibitor  Lactate Dehydrogenase a  Pyruvate Dehydrogenase Kinase  
Interfering with S100B–effector protein interactions for cancer therapy Journal article
Drug Discovery Today, 2020,Volume: 25,Issue: 9,Page: 1754-1761
Authors:  Wu,Ke Jia;  Wang,Wanhe;  Wang,Hui Min David;  Leung,Chung Hang;  Ma,Dik Lung
Favorite |  | TC[WOS]:5 TC[Scopus]:5 | Submit date:2021/03/01
Mimicking strategy for protein-protein interaction inhibitor discovery by virtual screening Journal article
Molecules, 2019,Volume: 24,Issue: 24
Authors:  Wu,Ke Jia;  Lei,Pui Man;  Liu,Hao;  Wu,Chun;  Leung,Chung Hang;  Ma,Dik Lung
Favorite |  | TC[WOS]:9 TC[Scopus]:10 | Submit date:2021/03/01
Drug Discovery  Mimetics  Protein-protein Interactions  Virtual Screening