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Upregulation of amplified in breast cancer 1 contributes to pancreatic ductal adenocarcinoma progression and vulnerability to blockage of hedgehog activation Journal article
Theranostics, 2021,Volume: 11,Issue: 4,Page: 1672-1689
Authors:  Li,Licen;  Bao,Jiaolin;  Wang,Haitao;  Lei,Josh Haipeng;  Peng,Cheng;  Zeng,Jianming;  Hao,Wenhui;  Zhang,Xu;  Xu,Xiaoling;  Yu,Chundong;  Deng,Chu Xia;  Chen,Qiang
Favorite |  | TC[WOS]:1 TC[Scopus]:0 | Submit date:2021/03/02
Aib1  Ecm  Hedgehog  Mafb  Pdac  
Enhanced Protein Damage Clearance Induces Broad Drug Resistance in Multitype of Cancers Revealed by an Evolution Drug-Resistant Model and Genome-Wide siRNA Screening Journal article
Advanced Science, 2020,Volume: 7,Issue: 23
Authors:  Shao,Fangyuan;  Lyu,Xueying;  Miao,Kai;  Xie,Lisi;  Wang,Haitao;  Xiao,Hao;  Li,Jie;  Chen,Qiang;  Ding,Renbo;  Chen,Ping;  Xing,Fuqiang;  Zhang,Xu;  Luo,Guang Hui;  Zhu,Wenli;  Cheng,Gregory;  Lon,Ng Wai;  Martin,Scott E.;  Wang,Guanyu;  Chen,Guokai;  Dai,Yunlu;  Deng,Chu Xia
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/02
Broad Drug Resistance  Caspase 3 Activation  Patient-derived Organoid  Proteolysis  Rnai Screening  
NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Miao,Kai;  Lei,Josh Haipeng;  Valecha,Monica Vishnu;  Zhang,Aiping;  Xu,Jun;  Wang,Lijian;  Lyu,Xueying;  Chen,Si;  Miao,Zhengqiang;  Zhang,Xin;  Su,Sek Man;  Shao,Fangyuan;  Rajendran,Barani Kumar;  Bao,Jiaolin;  Zeng,Jianming;  Sun,Heng;  Chen,Ping;  Tan,Kaeling;  Chen,Qiang;  Wong,Koon Ho;  Xu,Xiaoling;  Deng,Chu Xia
Favorite |  | TC[WOS]:7 TC[Scopus]:6 | Submit date:2020/09/16
Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells Journal article
Acta Pharmaceutica Sinica B, 2020,Volume: 10,Issue: 4,Page: 615-627
Authors:  Zhang,Baoyuan;  Lyu,Junfang;  Yang,Eun Ju;  Liu,Yifan;  Wu,Changjie;  Pardeshi,Lakhansing;  Tan,Kaeling;  Chen,Qiang;  Xu,Xiaoling;  Deng,Chu Xia;  Shim,Joong Sup
Favorite |  | TC[WOS]:10 TC[Scopus]:12 | Submit date:2020/09/16
Brca1  Breast Cancer  Dna Damage  Hdac  Histone Deacetylase  Reactive Oxygen Species  Synthetic Lethality  
BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis Journal article
Advanced Science, 2020,Volume: 7,Issue: 6
Authors:  Chen,Qiang;  Lei,Josh Haipeng;  Bao,Jiaolin;  Wang,Haitao;  Hao,Wenhui;  Li,Licen;  Peng,Cheng;  Masuda,Takaaki;  Miao,Kai;  Xu,Jun;  Xu,Xiaoling;  Deng,Chu Xia
Favorite |  | TC[WOS]:16 TC[Scopus]:16 | Submit date:2020/09/16
Atm-ampk-drp1  Brca1  Inflammasomes  Mitochondrial Dynamics  Mitophagy  
The metabolic footprint during adipocyte commitment highlights ceramide modulation as an adequate approach for obesity treatment Journal article
EBioMedicine, 2020,Volume: 51
Authors:  Hou,Weilong;  Chen,Qiang;  Wang,Haitao;  Qiu,Pengxiang;  Lyu,Xueying;  Chen,Weiping;  Chua,Melvin L.K.;  Chinn,Y. Eugene;  Deng,Chu Xia;  Wang,Ruihong
Favorite |  | TC[WOS]:1 TC[Scopus]:2 | Submit date:2020/09/16
Adipogenesis  Apoptosis  Ceramide  Epigenetic Modification  Metabolic Landscape  Metabolomics  Obesity  
BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy Journal article
Human molecular genetics, 2018
Authors:  Xiaoling Xu;  Eric Chen;  Lihua Mo;  Lei Zhang;  Fangyuan Shao;  Kai Miao;  Jianlin Liu;  Sek Man Su;  Monica Valecha;  Un In Chan;  Hongping Zheng;  Mark Chen;  Weiping Chen;  Qiang Chen;  Haiqing Fu;  Mirit I. Aladjem;  Yanzhen He;  Chu-Xia Deng
Favorite |  | TC[WOS]:4 TC[Scopus]:5 | Submit date:2018/12/17
BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition Journal article
Oncogene, 2018,Issue: 37,Page: 6341–6356
Authors:  Baoyuan Zhang;  Junfang Lyu;  Yifan Liu;  Changjie Wu;  Eun Ju Yang;  Lakhansing Pardeshi;  Kaeling Tan;  Koon Ho Wong;  Qiang Chen;  Xiaoling Xu;  Chu-Xia Deng;  Joong Sup Shim
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date:2018/12/17
A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 7,Page: 799–806
Authors:  Zhizhen Chen;  Jie Liu;  Dafeng Chu;  Yaming Shan;  Guixing Ma;  Hongmin Zhang;  Xiaohua Douglas Zhang;  Pu Wang;  Qiang Chen;  Chuxia Deng;  Weizao Chen;  Dimiter Dimitrov;  Qi Zhao
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2018/12/17
Insulin-like Growth Factor  Yeast Display  Affinity Maturation  Ead  
SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion Journal article
CELL REPORTS, 2017,Volume: 18,Issue: 13,Page: 3155-3166
Authors:  Chen, Qiang;  Hao, Wenhui;  Xiao, Cuiying;  Wang, Ruihong;  Xu, Xiaoling;  Lu, Huiyan;  Chen, Weiping;  Deng, Chu-Xia
Favorite |  | TC[WOS]:43 TC[Scopus]:42 | Submit date:2018/10/30