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Adeno-Associated Virus-Mediated RNAi against Mutant Alleles Attenuates Abnormal Calvarial Phenotypes in an Apert Syndrome Mouse Model Journal article
Molecular Therapy - Nucleic Acids, 2018,Volume: 13,Page: 291-302
Authors:  Luo,Fengtao;  Xie,Yangli;  Wang,Zuqiang;  Huang,Junlan;  Tan,Qiaoyan;  Sun,Xianding;  Li,Fangfang;  Li,Can;  Liu,Mi;  Zhang,Dali;  Xu,Meng;  Su,Nan;  Ni,Zhenhong;  Jiang,Wanling;  Chang,Jinhong;  Chen,Hangang;  Chen,Shuai;  Xu,Xiaoling;  Deng,Chuxia;  Wang,Zhugang;  Du,Xiaolan;  Chen,Lin
Favorite |  | TC[WOS]:8 TC[Scopus]:8 | Submit date:2020/09/16
Adeno-associated Virus  Apert Syndrome  Craniosynostosis  Fgfr2  Molecular Therapy  Rnai  
A novel FGFR1-binding peptide attenuates the degeneration ofarticular cartilage in adult mice Journal article
Osteoarthritis and Cartilage, 2018,Volume: 26,Issue: 12,Page: 1733-1743
Authors:  Q. Tan;  B. Chen;  Q. Wang;  W.Xu;  Y.Wang;  Z. Lin;  F.Luo;  S. Huang;  Y.Zhu;  N. Su;  M. Jin;  C.Li;  L. Kuang;  H.Qi;  Z.Ni;  Z. Wang;  X. Luo;  W. Jiang;  H. Chen;  S. Chen;  F.Li;  B. Zhang;  J. Huang;  R. Zhang;  K. Jin;  X.Xu;  C. Deng;  X.Du;  Y. Xie;  L. Chen
Favorite |  | TC[WOS]:7 TC[Scopus]:8 | Submit date:2018/12/17
Fgfr1  Peptide  Osteoarthritis  Mice  
Optimizing CRISPR/Cas9 technology for precise correction of the Fgfr3-Gly374Arg mutation in achondroplasia in mice Journal article
The Journal of Biological Chemistry, 2018
Authors:  Kai Miao;  Xin Zhang;  Sek Man Su;  Jianming Zeng;  Zebin Huang;  Un In Chan;  Xiaoling Xu;  Chu-Xia Deng
Favorite |  | TC[WOS]:6 TC[Scopus]:7 | Submit date:2018/12/17
Fgfr3  Crispr/cas9  Protein  Targeted Correction  Off-target  Achondroplasia  Dwarfism  Genome Editing  Gene Therapy  
BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy Journal article
Human molecular genetics, 2018
Authors:  Xiaoling Xu;  Eric Chen;  Lihua Mo;  Lei Zhang;  Fangyuan Shao;  Kai Miao;  Jianlin Liu;  Sek Man Su;  Monica Valecha;  Un In Chan;  Hongping Zheng;  Mark Chen;  Weiping Chen;  Qiang Chen;  Haiqing Fu;  Mirit I. Aladjem;  Yanzhen He;  Chu-Xia Deng
Favorite |  | TC[WOS]:4 TC[Scopus]:5 | Submit date:2018/12/17
BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition Journal article
Oncogene, 2018,Issue: 37,Page: 6341–6356
Authors:  Baoyuan Zhang;  Junfang Lyu;  Yifan Liu;  Changjie Wu;  Eun Ju Yang;  Lakhansing Pardeshi;  Kaeling Tan;  Koon Ho Wong;  Qiang Chen;  Xiaoling Xu;  Chu-Xia Deng;  Joong Sup Shim
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date:2018/12/17
Single-cell RNA-Seq reveals cell heterogeneity and hierarchy within mouse mammary epithelia Journal article
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018,Volume: 293,Issue: 22,Page: 8315-8329
Authors:  Sun, Heng;  Miao, Zhengqiang;  Zhang, Xin;  Chan, Un In;  Su, Sek Man;  Guo, Sen;  Wong, Chris Koon Ho;  Xu, Xiaoling;  Deng, Chu-Xia
Favorite |  | TC[WOS]:16 TC[Scopus]:15 | Submit date:2018/10/30
Mammary Gland  Development  Breast Cancer  Biomarker  Cell Differentiation  Stem Cells  cdh5+cell  Mammary Stem Cells (Mascs)  Single Cell Rna-seq  
Generation of Smurf2 conditional knockout mice Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 5,Page: 542-548
Authors:  Tang,Yi;  Tang,Liu Ya;  Xu,Xuan;  Li,Cuiling;  Deng,Chuxia;  Zhang,Ying E.
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2020/09/16
Knockout  Liver  LoxP  Mice  Smurf2  
Generation of Smurf2 conditional knockout mice Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 5,Page: 542-548
Authors:  Tang Y.;  Tang L.-Y.;  Xu X.;  Li C.;  Deng C.;  Zhang Y.E.
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2018/12/13
Knockout  Liver  Loxp  Mice  Smurf2  
BRCA1 function in the intra-S checkpoint is activated by acetylation via a pCAF/SIRT1 axis Journal article
ONCOGENE, 2018,Volume: 37,Issue: 17,Page: 2343-2350
Authors:  Lahusen, Tyler J.;  Kim, Seung-Jin;  Miao, Kai;  Huang, Zebin;  Xu, Xiaoling;  Deng, Chu-Xia
Favorite |  | TC[WOS]:11 TC[Scopus]:10 | Submit date:2018/10/30
Postnatal deletion of Alk5 gene in meniscal cartilage accelerates age-dependent meniscal degeneration in mice Journal article
Journal of Cellular Physiology, 2018,Volume: 234,Issue: 1,Page: 595-605
Authors:  Wang,Quan;  Tan,Qiaoyan;  Xu,Wei;  Kuang,Liang;  Zhang,Bin;  Wang,Zuqiang;  Ni,Zhenhong;  Su,Nan;  Jin,Min;  Li,Can;  Jiang,Wanling;  Huang,Junlan;  Li,Fangfang;  Zhu,Ying;  Chen,Hangang;  Du,Xiaolan;  Chen,Di;  Deng,Chuxia;  Qi,Huabing;  Xie,Yangli;  Chen,Lin
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2020/09/16
activing receptor-like kinases 5 (ALK5)  matrix degradation  meniscal degeneration  transforming growth factor-β (TGF-β) signaling