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Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential Journal article
Acta Pharmaceutica Sinica B, 2022,Volume: 12,Issue: 3,Page: 1019-1040
Authors:  Zhang, Wei;  Xu, Chengchao;  Sun, Jichao;  Shen, Han Ming;  Wang, Jigang;  Yang, Chuanbin
Favorite |  | TC[WOS]:10 TC[Scopus]:9 | Submit date:2022/04/06
Alzheimer's Disease (Ad)  Amyloid Beta (Aβ) Peptides  Autophagy  Autophagy Enhancers  Autophagy–lysosomal Pathway  Mapt/tau  Mitophagy  Neurodegenerative Diseases  
Murine Beta-Amyloid (1–42) Oligomers Disrupt Endothelial Barrier Integrity and VEGFR Signaling via Activating Astrocytes to Release Deleterious Soluble Factors Journal article
International Journal of Molecular Sciences, 2022,Volume: 23,Issue: 3
Authors:  Yue, Qian;  Zhou, Xinhua;  Zhang, Zaijun;  Hoi, Maggie Pui Man
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2022/03/04
Astrocytes  Blood–brain Barrier  Endothelial Cells  Murine Amyloid-beta  Tight Junctions  Vegfr2 Signaling Pathway  
Oxyphylla A ameliorates cognitive deficits and alleviates neuropathology via the Akt-GSK3β and Nrf2-Keap1-HO-1 pathways in vitro and in vivo murine models of Alzheimer's disease Journal article
Journal of Advanced Research, 2021,Volume: 34,Page: 1-12
Authors:  Bian, Yaqi;  Chen, Yan;  Wang, Xiufen;  Cui, Guozhen;  Ung, Carolina Oi Lam;  Lu, Jia Hong;  Cong, Weihong;  Tang, Benqin;  Lee, Simon Ming Yuen
Favorite |  | TC[WOS]:8 TC[Scopus]:7 | Submit date:2022/05/13
Alzheimer's Disease  Amyloid Beta Proteins  Oxidative Stress  Oxyphylla a  Samp8  
Tetramethylpyrazine nitrone (TBN), derivative from traditional Chinese medicine Chuan Xiong exerted a protective effect on neurovascular unit against mural amyloid-beta1-42 oligomers Conference paper
Medicinal and Food Plant Research & Natural Products and Biodiversity Resources
Authors:  Qian, E.;  Hoi, P. M.
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/08/10
TCM  neurovascular unit  amyloid beta  
9R, the cholinesterase and amyloid beta aggregation dual inhibitor, as a multifunctional agent to improve cognitive deficit and neuropathology in the triple-transgenic Alzheimer's disease mouse model Journal article
Neuropharmacology, 2020,Volume: 181
Authors:  Ju,Yaojun;  Tam,Kin Yip
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/03/04
Alzheimer's Disease  Amyloid Beta  Cholinesterase  Dual Inhibition  Multifunction  
Artemisinin improved Aβ- related pathological features and cognitive function of Alzheimer's disease Conference paper
2020 Academic Annual Meeting of Chronic Disease Prevention and Management Professional Committee of Chinese Society of Integrative Medicine and Geriatrics Professional Committee of World Federation of, N/A, 2020-12-01
Authors:  Zhao, X.;  Zheng, W.
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/08/31
Alzheimer's Disease  Artemisinin  Cognitive Behavior  Amyloid Beta  3×tg-ad Mouse  Sh-sy5ycells  
An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease Journal article
ACS Chemical Neuroscience, 2020,Volume: 11,Issue: 20,Page: 3346-3357
Authors:  Ju,Yaojun;  Chakravarty,Harapriya;  Tam,Kin Yip
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2021/03/04
Alzheimer's Disease  Amyloid Beta  Cholinesterase  Dual Inhibition  
A novel isoquinolinium dual inhibitor of cholinesterases and amyloid beta aggregation mitigates neuropathological changes in a triple-transgenic mouse model of Alzheimer’s disease Journal article
ACS Chemical Neuroscience, 2020,Page: 3346-3357
Authors:  Ju, Y.;  Chakravarty, H.;  Tam, K. Y.
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/07/27
Cholinesterase  Amyloid Beta  Dual Inhibition  Alzheimer’s Disease  
Dual targeting of cholinesterase and amyloid beta with pyridinium/isoquinolium derivatives Journal article
Drug Development Research, 2020,Volume: 81,Issue: 2,Page: 242-255
Authors:  Chakravarty,Harapriya;  Ju,Yaojun;  Chen,Wen Hua;  Tam,Kin Y.
Favorite |  | TC[WOS]:8 TC[Scopus]:8 | Submit date:2021/03/04
Acetylcholinesterase  Alzheimer's Disease  Amyloid Beta  Butyrylcholinesterase  Dual Target Inhibitor  Isoquinolinium  Pyridinium  
Fish oil protects the blood-brain barrier integrity in a mouse model of Alzheimer's disease Journal article
Chinese Medicine, 2020,Volume: 15,Issue: 1
Authors:  Xie,Youna;  Yan,Lingli;  Zeng,Haitao;  Chen,Weineng;  Lu,Jia Hong;  Wan,Jian Bo;  Su,Huanxing;  Yao,Xiaoli
Favorite |  | TC[WOS]:6 TC[Scopus]:7 | Submit date:2021/03/01
Amyloid Beta  Aβ-degrading Enzymes  Neuroinflammation  Nf-κb  Omega-3 Polyunsaturated Fatty Acids