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α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation Journal article
Phytomedicine, 2022,Volume: 101
Authors:  Chen, Jia Yue;  Zhu, Qi;  Cai, Cui Zan;  Luo, Hai Bin;  Lu, Jia Hong
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/31
Alpha-synuclein (Α-syn)  Parkinson's Disease  Phosphodiesterase 4 Inhibitor  Protein Kinase a (Pka)  Ubiquitin-proteasome System (Ups)  
Emerging roles of NRBF2/PI3KC3 axis in maintaining homeostasis of brain and guts Journal article
Neural Regeneration Research, 2022,Volume: 17,Issue: 2,Page: 323-324
Authors:  Wu, Ming Yue;  Cai, Cui Zan;  Yang, Chuanbin;  Yue, Zhenyu;  Chen, Ye;  Bian, Zhao Xiang;  Li, Min;  Lu, Jia Hong
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/03/04
Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow Journal article
Nature Biomedical Engineering, 2022,Volume: 6,Issue: 1,Page: 76-93
Authors:  Xie, Chenglong;  Zhuang, Xu Xu;  Niu, Zhangming;  Ai, Ruixue;  Lautrup, Sofie;  Zheng, Shuangjia;  Jiang, Yinghui;  Han, Ruiyu;  Gupta, Tanima Sen;  Cao, Shuqin;  Lagartos-Donate, Maria Jose;  Cai, Cui Zan;  Xie, Li Ming;  Caponio, Domenica;  Wang, Wen Wen;  Schmauck-Medina, Tomas;  Zhang, Jianying;  Wang, He ling;  Lou, Guofeng;  Xiao, Xianglu;  Zheng, Wenhua;  Palikaras, Konstantinos;  Yang, Guang;  Caldwell, Kim A.;  Caldwell, Guy A.;  Shen, Han Ming;  Nilsen, Hilde;  Lu, Jia Hong;  Fang, Evandro F.
Favorite |  | TC[WOS]:13 TC[Scopus]:17 | Submit date：2022/02/21
Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models Journal article
Theranostics, 2022,Volume: 12,Issue: 4,Page: 1738-1755
Authors:  Cai, Cui Zan;  Zhuang, Xu Xu;  Zhu, Qi;  Wu, Ming Yue;  Su, Huanxing;  Wang, Xiao Jin;  Iyaswamy, Ashok;  Yue, Zhenyu;  Wang, Qian;  Zhang, Bin;  Xue, Yu;  Tan, Jieqiong;  Li, Min;  He, Huanhuan;  Lu, Jia Hong
Favorite |  | TC[WOS]:0 TC[Scopus]:1 | Submit date：2022/05/17
Alzheimer's Disease  Autophagy  Aβ  Ccz1-mon1a  Rab7  
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation Journal article
Autophagy, 2021,Volume: 17,Issue: 5,Page: 1096-1111
Authors:  Wu,Ming Yue;  Liu,Le;  Wang,Er Jin;  Xiao,Hai Tao;  Cai,Cui Zan;  Wang,Jing;  Su,Huanxing;  Wang,Yitao;  Tan,Jieqiong;  Zhang,Zhuohua;  Wang,Juan;  Yao,Maojing;  Ouyang,De Fang;  Yue,Zhenyu;  Li,Min;  Chen,Ye;  Bian,Zhao Xiang;  Lu,Jia Hong
Favorite |  | TC[WOS]:22 TC[Scopus]:16 | Submit date：2021/03/01
Apoptotic Cell Clearance  Inflammatory Bowel Disease  Macrophage  Mon1-ccz1  Nrbf2  Rab7  
Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models Journal article
Phytomedicine, 2021,Volume: 87
Authors:  Zhu, Qi;  Zhuang, Xu xu;  Chen, Jia yue;  Yuan, Ning ning;  Chen, Yan;  Cai, Cui zan;  Tan, Jie qiong;  Su, Huan xing;  Lu, Jia hong
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date：2021/12/08
Camp/pka Pathway  Lycorine  Parkinson's Disease  Ubiquitin-proteasome System  Α-synuclein  
Comprehensive perspectives on experimental models for Parkinson's disease Journal article
Aging and Disease, 2021,Volume: 12,Issue: 1,Page: 223-246
Authors:  Ke, Minjing;  Chong, Cheong Meng;  Zhu, Qi;  Zhang, Ke;  Cai, Cui Zan;  Lu, Jia Hong;  Qin, Dajiang;  Su, Huanxing
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2021/12/07
Cellular Model  Cross-species Model  Experimental Model  Parkinson's Disease  Transgenic Animal  
NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation Journal article
Autophagy, 2020,Volume: 17,Issue: 5,Page: 1112-1130
Authors:  Cai,Cui Zan;  Yang,Chuanbin;  Zhuang,Xu Xu;  Yuan,Ning Ning;  Wu,Ming Yue;  Tan,Jie Qiong;  Song,Ju Xian;  Cheung,King Ho;  Su,Huanxing;  Wang,Yi Tao;  Tang,Bei Sha;  Behrends,Christian;  Durairajan,Siva Sundara Kumar;  Yue,Zhenyu;  Li,Min;  Lu,Jia Hong
Favorite |  | TC[WOS]:14 TC[Scopus]:15 | Submit date：2021/03/01
Amaturation  Autophagy  Ccz1-mon1a  Nrbf2  Pi3kc3  Rab7  Trafficking  Vps34  
Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models Journal article
Cell Death and Disease, 2020,Volume: 11,Issue: 2
Authors:  Zhuang,Xu Xu;  Wang,Sheng Fang;  Tan,Yuan;  Song,Ju Xian;  Zhu,Zhou;  Wang,Zi Ying;  Wu,Ming Yue;  Cai,Cui Zan;  Huang,Zhi Jian;  Tan,Jie Qiong;  Su,Huan Xing;  Li,Min;  Lu,Jia Hong
Favorite |  | TC[WOS]:39 TC[Scopus]:39 | Submit date：2021/03/01
Autophagy protein NRBF2 has reduced expression in Alzheimer's brains and modulates memory and amyloid-beta homeostasis in mice Journal article
Molecular Neurodegeneration, 2019,Volume: 14,Issue: 1
Authors:  Lachance,Véronik;  Wang,Qian;  Sweet,Eric;  Choi,Insup;  Cai,Cui Zan;  Zhuang,Xu Xu;  Zhang,Yuanxi;  Jiang,Jessica Li;  Blitzer,Robert D.;  Bozdagi-Gunal,Ozlem;  Zhang,Bin;  Lu,Jia Hong;  Yue,Zhenyu
Favorite |  | TC[WOS]:24 TC[Scopus]:25 | Submit date：2021/03/02