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S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy Journal article
Nature Communications, 2022,Volume: 13,Issue: 1
Authors:  Li, Jianjie;  Shu, Xiaodong;  Xu, Jun;  Su, Sek Man;  Chan, Un In;  Mo, Lihua;  Liu, Jianlin;  Zhang, Xin;  Adhav, Ragini;  Chen, Qiang;  Wang, Yuqing;  An, Tingting;  Zhang, Xu;  Lyu, Xueying;  Li, Xiaoling;  Lei, Josh Haipeng;  Miao, Kai;  Sun, Heng;  Xing, Fuqiang;  Zhang, Aiping;  Deng, Chuxia;  Xu, Xiaoling
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/13
ATP11B inhibits breast cancer metastasis in a mouse model by suppressing externalization of nonapoptotic phosphatidylserine Journal article
Journal of Clinical Investigation, 2022,Volume: 132,Issue: 5
Authors:  Xu, Jun;  Su, Sek Man;  Zhang, Xin;  Chan, Un In;  Adhav, Ragini;  Shu, Xiaodong;  Liu, Jianlin;  Li, Jianjie;  Mo, Lihua;  Wang, Yuqing;  An, Tingting;  Lei, Josh Haipeng;  Miao, Kai;  Deng, Chu Xia;  Xu, Xiaoling
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/03/28
Single-cell analysis reveals androgen receptor regulates the ER-to-Golgi trafficking pathway with CREB3L2 to drive prostate cancer progression Journal article
Oncogene, 2021,Volume: 40,Issue: 47,Page: 6479-6493
Authors:  Hu, Lingling;  Chen, Xin;  Narwade, Nitin;  Lim, Michelle Gek Liang;  Chen, Zikai;  Tennakoon, Chandana;  Guan, Peiyong;  Chan, Un In;  Zhao, Zuxianglan;  Deng, Mokan;  Xu, Xiaoling;  Sung, Wing Kin;  Cheung, Edwin
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date：2021/12/08
Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing Journal article
Theranostics, 2021,Volume: 11,Issue: 20,Page: 9967-9987
Authors:  Sun, Heng;  Zeng, Jianming;  Miao, Zhengqiang;  Lei, Kuan Cheok;  Huang, Chen;  Hu, Lingling;  Su, Sek Man;  Chan, Un In;  Miao, Kai;  Zhang, Xu;  Zhang, Aiping;  Guo, Sen;  Chen, Si;  Meng, Ya;  Deng, Min;  Hao, Wenhui;  Lei, Haipeng;  Lin, Ying;  Yang, Zhonglin;  Tang, Dongjiang;  Wong, Koon Ho;  Zhang, Xiaohua Douglas;  Xu, Xiaoling;  Deng, Chu Xia
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2021/11/30
Brca1/BRCA1  Mammary tumor  Mrc2  Single cell RNA-seq  Tumor heterogeneity  
Accelerating precision anti-cancer therapy by time-lapse and label-free 3D tumor slice culture platform Journal article
Theranostics, 2021,Volume: 11,Issue: 19,Page: 9415-9430
Authors:  Xing, Fuqiang;  Liu, Yu Cheng;  Huang, Shigao;  Lyu, Xueying;  Su, Sek Man;  Chan, Un In;  Wu, Pei Chun;  Yan, Yinghan;  Ai, Nana;  Li, Jianjie;  Zhao, Ming;  Rajendran, Barani Kumar;  Liu, Jianlin;  Shao, Fangyuan;  Sun, Heng;  Choi, Tak Kan;  Zhu, Wenli;  Luo, Guanghui;  Liu, Shuiming;  Xu, De Li;  Chan, Kin Long;  Zhao, Qi;  Miao, Kai;  Luo, Kathy Qian;  Ge, Wei;  Xu, Xiaoling;  Wang, Guanyu;  Liu, Tzu Ming;  Deng, Chu Xia
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date：2021/11/30
3D tumor slice culture  Apoptosis  FRET technique  Label-free  Personalized medicine  
Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Liu,Jianlin;  Adhav,Ragini;  Miao,Kai;  Su,Sek Man;  Mo,Lihua;  Chan,Un In;  Zhang,Xin;  Xu,Jun;  Li,Jianjie;  Shu,Xiaodong;  Zeng,Jianming;  Zhang,Xu;  Lyu,Xueying;  Pardeshi,Lakhansing;  Tan,Kaeling;  Sun,Heng;  Wong,Koon Ho;  Deng,Chuxia;  Xu,Xiaoling
Favorite |  | TC[WOS]:12 TC[Scopus]:14 | Submit date：2021/03/02
Optimizing CRISPR/Cas9 technology for precise correction of the Fgfr3-G374R mutation in achondroplasia in mice Journal article
Journal of Biological Chemistry, 2019,Volume: 294,Issue: 4,Page: 1142-1151
Authors:  Miao,Kai;  Zhang,Xin;  Su,Sek Man;  Zeng,Jianming;  Huang,Zebin;  Chan,Un In;  Xu,Xiaoling;  Deng,Chu Xia
Favorite |  | TC[WOS]:8 TC[Scopus]:9 | Submit date：2020/09/16
Optimizing CRISPR/Cas9 technology for precise correction of the Fgfr3-Gly374Arg mutation in achondroplasia in mice Journal article
The Journal of Biological Chemistry, 2018
Authors:  Kai Miao;  Xin Zhang;  Sek Man Su;  Jianming Zeng;  Zebin Huang;  Un In Chan;  Xiaoling Xu;  Chu-Xia Deng
Favorite |  | TC[WOS]:8 TC[Scopus]:9 | Submit date：2018/12/17
Fgfr3  Crispr/cas9  Protein  Targeted Correction  Off-target  Achondroplasia  Dwarfism  Genome Editing  Gene Therapy  
BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy Journal article
Human molecular genetics, 2018,Volume: 28,Issue: 5,Page: 842-857
Authors:  Xiaoling Xu;  Eric Chen;  Lihua Mo;  Lei Zhang;  Fangyuan Shao;  Kai Miao;  Jianlin Liu;  Sek Man Su;  Monica Valecha;  Un In Chan;  Hongping Zheng;  Mark Chen;  Weiping Chen;  Qiang Chen;  Haiqing Fu;  Mirit I. Aladjem;  Yanzhen He;  Chu-Xia Deng
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date：2018/12/17
Single-cell RNA-Seq reveals cell heterogeneity and hierarchy within mouse mammary epithelia Journal article
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018,Volume: 293,Issue: 22,Page: 8315-8329
Authors:  Sun, Heng;  Miao, Zhengqiang;  Zhang, Xin;  Chan, Un In;  Su, Sek Man;  Guo, Sen;  Wong, Chris Koon Ho;  Xu, Xiaoling;  Deng, Chu-Xia
Favorite |  | TC[WOS]:23 TC[Scopus]:19 | Submit date：2018/10/30
Mammary Gland  Development  Breast Cancer  Biomarker  Cell Differentiation  Stem Cells  cdh5+cell  Mammary Stem Cells (Mascs)  Single Cell Rna-seq