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Chemical Pretreatment Activated a Plastic State Amenable to Direct Lineage Reprogramming Journal article
Frontiers in Cell and Developmental Biology, 2022,Volume: 10
Authors:  Yang, Zhenghao;  Xu, Xiaochan;  Gu, Chan;  Nielsen, Alexander Valentin;  Chen, Guokai;  Guo, Fan;  Tang, Chao;  Zhao, Yang
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/13
cell fate transition  cell plasticity  chemical reprogramming  chromatin accessibility  direct reprogramming  
Thyroid hormone enhances stem cell maintenance and promotes lineage-specific differentiation in human embryonic stem cells Journal article
Stem Cell Research and Therapy, 2022,Volume: 13,Issue: 1
Authors:  Deng, Chunhao;  Zhang, Zhaoying;  Xu, Faxiang;  Xu, Jiaqi;  Ren, Zhili;  Godoy-Parejo, Carlos;  Xiao, Xia;  Liu, Weiwei;  Zhou, Zhou;  Chen, Guokai
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/13
Cell Culture  Hpscs  Pluripotency  Thyroid Hormone  Triiodothyronine (T3)  Trophoblast  
Nicotinamide promotes cardiomyocyte derivation and survival through kinase inhibition in human pluripotent stem cells Journal article
Cell Death and Disease, 2021,Volume: 12,Issue: 12
Authors:  Meng, Ya;  Song, Chengcheng;  Ren, Zhili;  Li, Xiaohong;  Yang, Xiangyu;  Ai, Nana;  Yang, Yang;  Wang, Dongjin;  Zhan, Meixiao;  Wang, Jiaxian;  Lei, Chon Lok;  Liu, Weiwei;  Ge, Wei;  Lu, Ligong;  Chen, Guokai
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2021/12/08
Regulation of energy metabolism in human pluripotent stem cells Journal article
Cellular and Molecular Life Sciences, 2021,Volume: 78,Issue: 24,Page: 8097-8108
Authors:  Liu, Weiwei;  Chen, Guokai
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2021/12/08
Glycolysis  Insulin  Nutrient  Oxidative Phosphorylation  Oxygen  Ph  
Nicotinamide promotes pancreatic differentiation through the dual inhibition of CK1 and ROCK kinases in human embryonic stem cells Journal article
Stem Cell Research and Therapy, 2021,Volume: 12,Issue: 1
Authors:  Zhang, Yumeng;  Xu, Jiaqi;  Ren, Zhili;  Meng, Ya;  Liu, Weiwei;  Lu, Ligong;  Zhou, Zhou;  Chen, Guokai
Favorite |  | TC[WOS]:5 TC[Scopus]:4 | Submit date：2021/12/09
Casein Kinase 1 (Ck1)  Human Embryonic Stem Cells  Kinase Inhibitor  Nicotinamide  Pancreatic Progenitors  Rho-associated Protein Kinase (Rock)  
Targeting B7-H3 via chimeric antigen receptor T cells and bispecific killer cell engagers augments antitumor response of cytotoxic lymphocytes Journal article
Journal of Hematology and Oncology, 2021,Volume: 14,Issue: 1
Authors:  Liu,Jie;  Yang,Shuo;  Cao,Bihui;  Zhou,Guangyu;  Zhang,Fengjuan;  Wang,Yuan;  Wang,Rixin;  Zhu,Lipeng;  Meng,Ya;  Hu,Cong;  Liang,Hui;  Lin,Xu;  Zhu,Kangshun;  Chen,Guokai;  Luo,Kathy Qian;  Di,Lijun;  Zhao,Qi
Favorite |  | TC[WOS]:14 TC[Scopus]:14 | Submit date：2021/03/04
B7-h3  Bike  Bispecific Antibody  Car t  Chimeric Antigen Receptor  Non-small Cell Lung Cancer  Pd-l1  
Lysophosphatidic acid shifts metabolic and transcriptional landscapes to induce a distinct cellular state in human pluripotent stem cells Journal article
Cell Reports, 2021,Volume: 37,Issue: 9
Authors:  Xu, Faxiang;  Deng, Chunhao;  Ren, Zhili;  Sun, Liangyu;  Meng, Ya;  Liu, Weiwei;  Wan, Jianbo;  Chen, Guokai
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date：2021/12/08
cellular state  hPSC  lipid  LPA  metabolism  mitochondria  pluripotency  transcriptome  
Protocol for intracellular and extracellular metabolite detection in human embryonic stem cells Journal article
STAR Protocols, 2021,Volume: 2,Issue: 3
Authors:  Xu, Faxiang;  Song, Chengcheng;  Liu, Weiwei;  Chen, Guokai
Favorite |  | TC[WOS]:0 TC[Scopus]:3 | Submit date：2021/12/08
Cell culture  Cell Differentiation  Flow Cytometry/Mass Cytometry  Metabolism  Metabolomics  Stem Cells  
Insulin Promotes Mitochondrial Respiration and Survival through PI3K/AKT/GSK3 Pathway in Human Embryonic Stem Cells Journal article
Stem Cell Reports, 2020,Volume: 15,Issue: 6,Page: 1362-1376
Authors:  Ren,Zhili;  Zhong,Hui;  Song,Chengcheng;  Deng,Chunhao;  Hsieh,Hsun Ting;  Liu,Weiwei;  Chen,Guokai
Favorite |  | TC[WOS]:8 TC[Scopus]:9 | Submit date：2021/03/02
Akt  Caspase  Cell Survival  Gsk3  Human Embryonic Stem Cells  Insulin  Mitochondrial Respiration  
Enhanced Protein Damage Clearance Induces Broad Drug Resistance in Multitype of Cancers Revealed by an Evolution Drug-Resistant Model and Genome-Wide siRNA Screening Journal article
Advanced Science, 2020,Volume: 7,Issue: 23
Authors:  Shao,Fangyuan;  Lyu,Xueying;  Miao,Kai;  Xie,Lisi;  Wang,Haitao;  Xiao,Hao;  Li,Jie;  Chen,Qiang;  Ding,Renbo;  Chen,Ping;  Xing,Fuqiang;  Zhang,Xu;  Luo,Guang Hui;  Zhu,Wenli;  Cheng,Gregory;  Lon,Ng Wai;  Martin,Scott E.;  Wang,Guanyu;  Chen,Guokai;  Dai,Yunlu;  Deng,Chu Xia
Favorite |  | TC[WOS]:3 TC[Scopus]:4 | Submit date：2021/03/02
Broad Drug Resistance  Caspase 3 Activation  Patient-derived Organoid  Proteolysis  Rnai Screening