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Synthesis and pharmacological validation of fluorescent diarylsulfonylurea analogues as NLRP3 inhibitors and imaging probes Journal article
European Journal of Medicinal Chemistry, 2022,Volume: 237
Authors:  Zhao, Jiannan;  Li, Yongling;  Ma, Jing;  Liu, Jingting;  Xiao, Ruoxuan;  Wang, Linlin;  Li, Peng;  He, Yinyan;  Qian, Feng;  Zhang, Ao;  Sun, Zhen Liang;  Ding, Chunyong
Favorite |  | TC[WOS]:1 TC[Scopus]:2 | Submit date:2022/05/13
Fluorescence Imaging  Inflammasome  Inhibitor  Nlrp3  Sulfonylurea  
Natural and synthetic β-carboline as a privileged antifungal scaffolds Journal article
European Journal of Medicinal Chemistry, 2022,Volume: 229
Authors:  Dai, Jiang Kun;  Dan, Wen Jia;  Wan, Jian Bo
Favorite |  | TC[WOS]:2 TC[Scopus]:3 | Submit date:2022/03/04
Antifungal  Mechanism  Structure-activity Relationships  Β-carboline  
Pharmacological inhibition of KDM5A for cancer treatment Journal article
European Journal of Medicinal Chemistry, 2021,Volume: 226
Authors:  Yang, Guan Jun;  Wu, Jia;  Miao, Liang;  Zhu, Ming Hui;  Zhou, Qian Jin;  Lu, Xin Jiang;  Lu, Jian Fei;  Leung, Chung Hang;  Ma, Dik Lung;  Chen, Jiong
Favorite |  | TC[WOS]:5 TC[Scopus]:3 | Submit date:2021/12/08
Cancer Therapy  Drug Resistance  Histone Methylation  Lysine-specific Demethylase 5a  Screening Methods  
Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity Journal article
European Journal of Medicinal Chemistry, 2021,Volume: 214
Authors:  Xu,Biao;  Wang,Zhi Peng;  Liu,Qingwang;  Yang,Xiaohong;  Li,Xuemin;  Huang,Ding;  Qiu,Yanfei;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2021/03/04
Cancer Metabolism  Proliferation  Pyruvate Dehydrogenase Kinase  Structure-activity Relationship  
Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation Journal article
European Journal of Medicinal Chemistry, 2020,Volume: 203
Authors:  Xiang,Sichuan;  Huang,Ding;  He,Qiaolin;  Li,Jie;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
Favorite |  | TC[WOS]:5 TC[Scopus]:5 | Submit date:2021/03/04
Cancer Metabolism  Cancer Proliferation  Dual Inhibitor  Lactate Dehydrogenase a  Pyruvate Dehydrogenase Kinase  
Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing Journal article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018,Volume: 143,Page: 1021-1027
Authors:  Wu, Ke-Jia;  Zhong, Hai-Jing;  Li, Guodong;  Liu, Chenfu;  Wang, Hui-Min David;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite |  | TC[WOS]:40 TC[Scopus]:40 | Submit date:2018/10/30
Drug Repurposing  Mitoxantrone  Nedd8  Ubiquitin  
Discovery and optimization of novel dual dithiocarbamates as potent anticancer agents Journal article
European Journal of Medicinal Chemistry, 2015,Volume: 93,Page: 381
Authors:  Li R.-D.;  Wang H.-L.;  Li Y.-B.;  Wang Z.-Q.;  Wang X.;  Wang Y.-T.;  Ge Z.-M.;  Li R.-T.
Favorite |  | TC[WOS]:40 TC[Scopus]:40 | Submit date:2018/10/31
Anti-tumor Activity  Dual Dithiocarbamate  Structureeactivity Relationship  Synthesis