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Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm Journal article
Acta Pharmaceutica Sinica B, 2022
Authors:  Wang, Wei;  Feng, Shuo;  Ye, Zhuyifan;  Gao, Hanlu;  Lin, Jinzhong;  Ouyang, Defang
Favorite |  | TC[WOS]:0 TC[Scopus]:1 | Submit date:2022/05/17
Formulation Prediction  Ionizable Lipid  Lightgbm  Lipid Nanoparticle  Machine Learning  Molecular Modeling  Mrna  Vaccine  
In silico formulation prediction of drug/cyclodextrin/polymer ternary complexes by machine learning and molecular modeling techniques Journal article
Carbohydrate Polymers, 2022,Volume: 275
Authors:  Li, Junjun;  Gao, Hanlu;  Ye, Zhuyifan;  Deng, Jiayin;  Ouyang, Defang
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2022/02/21
Machine Learning  Molecular Modeling  Random Forest  Solubility Prediction  Ternary Cyclodextrin Complexes  
The important herbal pair for the treatment of COVID-19 and its possible mechanisms Journal article
Chinese Medicine, 2021,Volume: 16,Issue: 1
Authors:  Xia, Shujie;  Zhong, Zhangfeng;  Gao, Bizhen;  Vong, Chi Teng;  Lin, Xuejuan;  Cai, Jin;  Gao, Hanlu;  Chan, Ging;  Li, Candong
Favorite |  | TC[WOS]:12 TC[Scopus]:15 | Submit date:2021/12/09
Amygdalus Communis Vas  Association Rules  Ephedra Sinica Stapf  Herbal Pair  Molecular Docking  Network Pharmacology  Novel Coronavirus Pneumonia  
Computational pharmaceutics - A new paradigm of drug delivery Journal article
Journal of Controlled Release, 2021,Volume: 338,Page: 119-136
Authors:  Wang, Wei;  Ye, Zhuyifan;  Gao, Hanlu;  Ouyang, Defang
Favorite |  | TC[WOS]:16 TC[Scopus]:18 | Submit date:2021/12/08
Artificial Intelligence  Computational Pharmaceutics  Machine Learning  Mathematical Modeling  Molecular Modeling  Pbpk Modeling  Process Simulation  
PharmSD: A novel AI-based computational platform for solid dispersion formulation design Journal article
International Journal of Pharmaceutics, 2021,Volume: 604
Authors:  Dong, Jie;  Gao, Hanlu;  Ouyang, Defang
Favorite |  | TC[WOS]:2 TC[Scopus]:5 | Submit date:2021/12/08
Computational Platform  Drug Design  Formulation  Machine Learning  Solid Dispersion  Web Server  
Using Acetone/Water Binary Solvent to Enhance the Stability and Bioavailability of Spray Dried Enzalutamide/HPMC-AS Solid Dispersions Journal article
Journal of Pharmaceutical Sciences, 2021,Volume: 110,Issue: 3,Page: 1160-1171
Authors:  Zhang,Xiaoting;  Rao,Qiuhong;  Qiu,Zhenwen;  Lin,Yisheng;  Zhang,Lei;  Hu,Qingzhong;  Chen,Tingting;  Ma,Zhimin;  Gao,Hanlu;  Luo,Dandong;  Zhao,Jiaqi;  Ouyang,Defang;  Zhang,Zhenyu Jason;  Li,Qingguo
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/03/02
Amorphous Solid Dispersion  Drug-excipient Interaction  Particle Size  Poorly Water-soluble Drug  Spray Drying  
An integrated computational methodology with data-driven machine learning, molecular modeling and PBPK modeling to accelerate solid dispersion formulation design Journal article
European Journal of Pharmaceutics and Biopharmaceutics, 2021,Volume: 158,Page: 336-346
Authors:  Gao,Hanlu;  Wang,Wei;  Dong,Jie;  Ye,Zhuyifan;  Ouyang,Defang
Favorite |  | TC[WOS]:14 TC[Scopus]:16 | Submit date:2021/03/02
Dissolution Profile  Machine Learning  Molecular Dynamics (Md) Simulations  Pharmacokinetic Modeling  Solid Dispersion  
Predicting drug/phospholipid complexation by the lightGBM method Journal article
Chemical Physics Letters, 2020,Volume: 747
Authors:  Gao,Haoshi;  Ye,Zhuyifan;  Dong,Jie;  Gao,Hanlu;  Yu,Hua;  Li,Haifeng;  Ouyang,Defang
Favorite |  | TC[WOS]:13 TC[Scopus]:14 | Submit date:2021/03/02
The novel platinum(IV) prodrug with self-assembly property and structure-transformable character against triple-negative breast cancer Journal article
Biomaterials, 2020,Volume: 232
Authors:  Yang,Conglian;  Tu,Kun;  Gao,Hanlu;  Zhang,Liao;  Sun,Yu;  Yang,Ting;  Kong,Li;  Ouyang,Defang;  Zhang,Zhiping
Favorite |  | TC[WOS]:17 TC[Scopus]:17 | Submit date:2021/03/02
Adjudin  Drug Resistance  Platinum(Iv) Prodrug  Self-assembly  Structure Transform  Triple-negative Breast Cancer