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Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity Journal article
European Journal of Medicinal Chemistry, 2021,Volume: 214
Authors:  Xu,Biao;  Wang,Zhi Peng;  Liu,Qingwang;  Yang,Xiaohong;  Li,Xuemin;  Huang,Ding;  Qiu,Yanfei;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/04
Cancer metabolism  Proliferation  Pyruvate dehydrogenase kinase  Structure-activity relationship  
Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation Journal article
Oncogene, 2021,Volume: 40,Issue: 1,Page: 97-111
Authors:  Zhang,Qingyu;  Zhou,Wei;  Yu,Shan;  Ju,Yaojun;  To,Sally Kit Yan;  Wong,Alice Sze Tsai;  Jiao,Yufei;  Poon,Terence Chuen Wai;  Tam,Kin Yip;  Lee,Leo Tsz On
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Recent developments of human monocarboxylate transporter (hMCT) inhibitors as anticancer agents Journal article
Drug Discovery Today, 2021
Authors:  Wu,Puhua;  Zhou,Yan;  Guo,Yizhen;  Zhang,Shao Lin;  Tam,Kin Yip
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9R, the cholinesterase and amyloid beta aggregation dual inhibitor, as a multifunctional agent to improve cognitive deficit and neuropathology in the triple-transgenic Alzheimer's disease mouse model Journal article
Neuropharmacology, 2020,Volume: 181
Authors:  Ju,Yaojun;  Tam,Kin Yip
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Alzheimer's disease  Amyloid beta  Cholinesterase  Dual inhibition  Multifunction  
An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease Journal article
ACS Chemical Neuroscience, 2020,Volume: 11,Issue: 20,Page: 3346-3357
Authors:  Ju,Yaojun;  Chakravarty,Harapriya;  Tam,Kin Yip
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Alzheimer's disease  amyloid beta  cholinesterase  dual inhibition  
Synthesis and biological effect of lysosome-targeting fluorescent anion transporters with enhanced anionophoric activity Journal article
Bioorganic and Medicinal Chemistry Letters, 2020,Volume: 30,Issue: 19
Authors:  Hong,Xiao Qiao;  He,Xiang Yu;  Tam,Kin Yip;  Chen,Wen Hua
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Cathepsin B enzyme  Fluorescent anion transporter  Lysosomal alkalization  Lysosome targeting  
Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation Journal article
European Journal of Medicinal Chemistry, 2020,Volume: 203
Authors:  Xiang,Sichuan;  Huang,Ding;  He,Qiaolin;  Li,Jie;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
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Cancer metabolism  Cancer proliferation  Dual inhibitor  Lactate dehydrogenase A  Pyruvate dehydrogenase kinase  
Novel Therapeutic Anti-ADAM17 Antibody A9(B8) Enhances EGFR-TKI–Mediated Anticancer Activity in NSCLC Journal article
Translational Oncology, 2019,Volume: 12,Issue: 11,Page: 1516-1524
Authors:  Yang,Zheng;  Chan,Kin Iong;  Kwok,Hang Fai;  Tam,Kin Yip
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A Model of Hereditary Sensory and Autonomic Neuropathy Type 1 Reveals a Role of Glycosphingolipids in Neuronal Polarity Journal article
JOURNAL OF NEUROSCIENCE, 2019,Volume: 39,Issue: 29,Page: 5816-5834
Authors:  Mengqiao Cui;  Rong Ying;  Xue Jiang;  Gang Li;  Xuanjun Zhang;  Jun Zheng;  Kin Yip Tam;  Bin Liang;  Anbing Shi;  Verena Göbel;  Hongjie Zhang
Favorite |  | TC[WOS]:6 TC[Scopus]:6 | Submit date:2020/05/19
Axonal Transport  Glucosylceramide  Hsan1  Neuronal Polarity  Sphingolipidomics  Sphingolipids  
Synthesis and biological evaluation of aza-crown ether–squaramide conjugates as anion/cation symporters Journal article
FUTURE MEDICINAL CHEMISTRY, 2019,Volume: 11,Issue: 10,Page: 1091-1106
Authors:  Xi-Hui Yu;  Xiong-Jie Cai;  Xiao-Qiao Hong;  Kin Yip Tam;  Kun Zhang;  Wen-Hua Chen
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date:2020/05/21